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The molecular mechanism of intestinal levodopa absorption and its possible implications for the treatment of Parkinson's disease.

Camargo SM, Vuille-dit-Bille RN, Mariotta L, Ramadan T, Huggel K, Singer D, Götze O, Verrey F.

J Pharmacol Exp Ther. 2014 Oct;351(1):114-23. doi: 10.1124/jpet.114.216317. Epub 2014 Jul 29.


Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway.

Ramadan T, Camargo SM, Summa V, Hunziker P, Chesnov S, Pos KM, Verrey F.

J Cell Physiol. 2006 Mar;206(3):771-9.


Recycling of aromatic amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchanger.

Ramadan T, Camargo SM, Herzog B, Bordin M, Pos KM, Verrey F.

Pflugers Arch. 2007 Jun;454(3):507-16. Epub 2007 Feb 2.


T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control.

Mariotta L, Ramadan T, Singer D, Guetg A, Herzog B, Stoeger C, Palacín M, Lahoutte T, Camargo SM, Verrey F.

J Physiol. 2012 Dec 15;590(Pt 24):6413-24. doi: 10.1113/jphysiol.2012.239574. Epub 2012 Oct 8.


Involvement of rBAT in Na(+)-dependent and -independent transport of the neurotransmitter candidate L-DOPA in Xenopus laevis oocytes injected with rabbit small intestinal epithelium poly A(+) RNA.

Ishiia H, Sasaki Y, Goshima Y, Kanai Y, Endou H, Ayusawa D, Ono H, Miyamae T, Misu Y.

Biochim Biophys Acta. 2000 Jun 1;1466(1-2):61-70.


Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.

Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H.

J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20.


Functional cooperation of epithelial heteromeric amino acid transporters expressed in madin-darby canine kidney cells.

Bauch C, Forster N, Loffing-Cueni D, Summa V, Verrey F.

J Biol Chem. 2003 Jan 10;278(2):1316-22. Epub 2002 Nov 1.


Intestinal peptidases form functional complexes with the neutral amino acid transporter B(0)AT1.

Fairweather SJ, Bröer A, O'Mara ML, Bröer S.

Biochem J. 2012 Aug 15;446(1):135-48. doi: 10.1042/BJ20120307.


Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1.

Tamai I, Nakanishi T, Nakahara H, Sai Y, Ganapathy V, Leibach FH, Tsuji A.

J Pharm Sci. 1998 Dec;87(12):1542-6.


Evidence of D-phenylglycine as delivering tool for improving L-dopa absorption.

Wang CL, Fan YB, Lu HH, Tsai TH, Tsai MC, Wang HP.

J Biomed Sci. 2010 Sep 6;17:71. doi: 10.1186/1423-0127-17-71.


Pharmacokinetic optimisation in the treatment of Parkinson's disease.

Contin M, Riva R, Albani F, Baruzzi A.

Clin Pharmacokinet. 1996 Jun;30(6):463-81. Review. Erratum in: Clin Pharmacokinet 1996 Aug;31(2):110.


Obligatory amino acid exchange via systems bo,+-like and y+L-like. A tertiary active transport mechanism for renal reabsorption of cystine and dibasic amino acids.

Chillarón J, Estévez R, Mora C, Wagner CA, Suessbrich H, Lang F, Gelpí JL, Testar X, Busch AE, Zorzano A, Palacín M.

J Biol Chem. 1996 Jul 26;271(30):17761-70.


Defective intestinal amino acid absorption in Ace2 null mice.

Singer D, Camargo SM, Ramadan T, Schäfer M, Mariotta L, Herzog B, Huggel K, Wolfer D, Werner S, Penninger JM, Verrey F.

Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15;303(6):G686-95. doi: 10.1152/ajpgi.00140.2012. Epub 2012 Jul 12.


Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule.

Park SY, Kim JK, Kim IJ, Choi BK, Jung KY, Lee S, Park KJ, Chairoungdua A, Kanai Y, Endou H, Kim DK.

Arch Pharm Res. 2005 Apr;28(4):421-32.


Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b0,+AT (Slc7a9) in mice.

Di Giacopo A, Rubio-Aliaga I, Cantone A, Artunc F, Rexhepaj R, Frey-Wagner I, Font-Llitjós M, Gehring N, Stange G, Jaenecke I, Mohebbi N, Closs EI, Palacín M, Nunes V, Daniel H, Lang F, Capasso G, Wagner CA.

Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1645-55. doi: 10.1152/ajprenal.00221.2013. Epub 2013 Oct 9.


Cloning and expression of a b(0,+)-like amino acid transporter functioning as a heterodimer with 4F2hc instead of rBAT. A new candidate gene for cystinuria.

Rajan DP, Kekuda R, Huang W, Wang H, Devoe LD, Leibach FH, Prasad PD, Ganapathy V.

J Biol Chem. 1999 Oct 8;274(41):29005-10.

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