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Items: 1 to 20 of 226

1.

Suppression of the TGF-β/Smad signaling pathway and inhibition of hepatic stellate cell proliferation play a role in the hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis.

Chen N, Geng Q, Zheng J, He S, Huo X, Sun X.

Int J Mol Med. 2014 Oct;34(4):1110-6. doi: 10.3892/ijmm.2014.1867. Epub 2014 Jul 25.

PMID:
25069637
2.

Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro.

Tang LX, He RH, Yang G, Tan JJ, Zhou L, Meng XM, Huang XR, Lan HY.

PLoS One. 2012;7(2):e31350. doi: 10.1371/journal.pone.0031350. Epub 2012 Feb 7.

3.
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Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway.

Balta C, Herman H, Boldura OM, Gasca I, Rosu M, Ardelean A, Hermenean A.

Chem Biol Interact. 2015 Oct 5;240:94-101. doi: 10.1016/j.cbi.2015.08.013. Epub 2015 Aug 20.

PMID:
26297989
5.

Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitro.

Choi YJ, Kim da H, Kim SJ, Kim J, Jeong SI, Chung CH, Yu KY, Kim SY.

Life Sci. 2014 Jul 17;108(2):94-103. doi: 10.1016/j.lfs.2014.05.012. Epub 2014 May 28.

PMID:
24880074
6.

Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells.

Zhang F, Zhang Z, Chen L, Kong D, Zhang X, Lu C, Lu Y, Zheng S.

J Cell Mol Med. 2014 Jul;18(7):1392-406. doi: 10.1111/jcmm.12286. Epub 2014 Apr 30.

7.

Salvianolic acid B inhibits hepatic stellate cell activation through transforming growth factor beta-1 signal transduction pathway in vivo and in vitro.

Tao YY, Wang QL, Shen L, Fu WW, Liu CH.

Exp Biol Med (Maywood). 2013 Nov 1;238(11):1284-96. doi: 10.1177/1535370213498979. Epub 2013 Sep 4.

PMID:
24006304
8.

Astragalus and Paeoniae Radix Rubra extract (APE) inhibits hepatic stellate cell activation by modulating transforming growth factor-β/Smad pathway.

Huang W, Li L, Tian X, Yan J, Yang X, Wang X, Liao G, Qiu G.

Mol Med Rep. 2015 Apr;11(4):2569-77. doi: 10.3892/mmr.2014.3026. Epub 2014 Dec 1.

9.

Antifibrotic effects of protocatechuic aldehyde on experimental liver fibrosis.

Li C, Jiang W, Zhu H, Hou J.

Pharm Biol. 2012 Apr;50(4):413-9. doi: 10.3109/13880209.2011.608193. Epub 2011 Dec 1. Retraction in: Pezzuto JM, Patel P. Pharm Biol. 2013 May;51(5):675.

PMID:
22129045
10.

Astragalus and Paeoniae radix rubra extract inhibits liver fibrosis by modulating the transforming growth factor‑β/Smad pathway in rats.

Huang W, Li L, Tian X, Yan J, Yang X, Wang X, Liao G, Qiu G.

Mol Med Rep. 2015 Feb;11(2):805-14. doi: 10.3892/mmr.2014.2868. Epub 2014 Nov 5.

11.

Potent effects of dioscin against liver fibrosis.

Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J.

Sci Rep. 2015 Apr 8;5:9713. doi: 10.1038/srep09713.

12.

Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect.

Xu L, Zheng N, He Q, Li R, Zhang K, Liang T.

Phytomedicine. 2013 Oct 15;20(13):1172-9. doi: 10.1016/j.phymed.2013.06.008. Epub 2013 Jul 13.

PMID:
23856441
13.

Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-β/Smad interference.

Jiang Y, Wang C, Li YY, Wang XC, An JD, Wang YJ, Wang XJ.

J Ethnopharmacol. 2014 Dec 2;158 Pt A:230-8. doi: 10.1016/j.jep.2014.10.028. Epub 2014 Oct 24.

PMID:
25456431
15.

Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways.

Li J, Li X, Xu W, Wang S, Hu Z, Zhang Q, Deng X, Wang J, Zhang J, Guo C.

Liver Int. 2015 Apr;35(4):1222-33. doi: 10.1111/liv.12638. Epub 2014 Aug 5.

PMID:
25040634
16.

Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats.

Li J, Liu P, Zhang R, Cao L, Qian H, Liao J, Xu W, Wu M, Yin Z.

J Ethnopharmacol. 2011 Sep 1;137(1):714-23. doi: 10.1016/j.jep.2011.06.030. Epub 2011 Jun 24.

PMID:
21726622
17.

Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis.

Li JP, Gao Y, Chu SF, Zhang Z, Xia CY, Mou Z, Song XY, He WB, Guo XF, Chen NH.

Acta Pharmacol Sin. 2014 Aug;35(8):1031-44. doi: 10.1038/aps.2014.41. Epub 2014 Jun 30.

18.

Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis.

De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Millán C, Brenner DA, Vivarelli M, Mocchegiani F, Marzioni M, Benedetti A, Svegliati-Baroni G.

Am J Pathol. 2013 Sep;183(3):820-30. doi: 10.1016/j.ajpath.2013.05.030. Epub 2013 Jul 11.

PMID:
23850082
19.

The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway.

Yu DK, Zhang CX, Zhao SS, Zhang SH, Zhang H, Cai SY, Shao RG, He HW.

Acta Pharmacol Sin. 2015 Apr;36(4):473-82. doi: 10.1038/aps.2014.155. Epub 2015 Mar 16.

20.
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