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Results: 1 to 20 of 90

1.

Retinal and nonocular abnormalities in cyp27a1(-/-)cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol.

Saadane A, Mast N, Charvet CD, Omarova S, Zheng W, Huang SS, Kern TS, Peachey NS, Pikuleva IA.

Am J Pathol. 2014 Sep;184(9):2403-19. doi: 10.1016/j.ajpath.2014.05.024. Epub 2014 Jul 25.

PMID:
25065682
[PubMed - in process]
2.

Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.

Omarova S, Charvet CD, Reem RE, Mast N, Zheng W, Huang S, Peachey NS, Pikuleva IA.

J Clin Invest. 2012 Aug 1;122(8):3012-23. doi: 10.1172/JCI63816. Epub 2012 Jul 23.

PMID:
22820291
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain.

Liao WL, Heo GY, Dodder NG, Reem RE, Mast N, Huang S, Dipatre PL, Turko IV, Pikuleva IA.

J Proteome Res. 2011 Jan 7;10(1):241-8. doi: 10.1021/pr1008898. Epub 2010 Nov 16.

PMID:
21049985
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina.

Bretillon L, Diczfalusy U, Björkhem I, Maire MA, Martine L, Joffre C, Acar N, Bron A, Creuzot-Garcher C.

Curr Eye Res. 2007 Apr;32(4):361-6.

PMID:
17453958
[PubMed - indexed for MEDLINE]
5.

Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells.

Milagre I, Olin M, Nunes MJ, Moutinho M, Lövgren-Sandblom A, Gama MJ, Björkhem I, Rodrigues E.

Neurochem Int. 2012 Jan;60(2):192-8. doi: 10.1016/j.neuint.2011.12.003. Epub 2011 Dec 13.

PMID:
22185844
[PubMed - indexed for MEDLINE]
6.

Oxysterols: functional significance in fetal development and the maintenance of normal retinal function.

Javitt NB.

Curr Opin Lipidol. 2007 Jun;18(3):283-8.

PMID:
17495602
[PubMed - indexed for MEDLINE]
7.

Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.

Heo GY, Liao WL, Turko IV, Pikuleva IA.

Arch Biochem Biophys. 2012 Feb 15;518(2):119-26. doi: 10.1016/j.abb.2011.12.016. Epub 2011 Dec 29.

PMID:
22227097
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells.

Heo GY, Bederman I, Mast N, Liao WL, Turko IV, Pikuleva IA.

J Lipid Res. 2011 Jun;52(6):1117-27. doi: 10.1194/jlr.M014217. Epub 2011 Mar 16.

PMID:
21411718
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Differential expression of cholesterol hydroxylases in Alzheimer's disease.

Brown J 3rd, Theisler C, Silberman S, Magnuson D, Gottardi-Littell N, Lee JM, Yager D, Crowley J, Sambamurti K, Rahman MM, Reiss AB, Eckman CB, Wolozin B.

J Biol Chem. 2004 Aug 13;279(33):34674-81. Epub 2004 May 17.

PMID:
15148325
[PubMed - indexed for MEDLINE]
Free Article
10.

Retinal degeneration and local oxygen metabolism.

Yu DY, Cringle SJ.

Exp Eye Res. 2005 Jun;80(6):745-51. Review.

PMID:
15939030
[PubMed - indexed for MEDLINE]
11.

Cholesterol-metabolizing cytochromes P450.

Pikuleva IA.

Drug Metab Dispos. 2006 Apr;34(4):513-20. Epub 2006 Jan 24. Review.

PMID:
16434543
[PubMed - indexed for MEDLINE]
Free Article
12.

The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina.

SanGiovanni JP, Chew EY.

Prog Retin Eye Res. 2005 Jan;24(1):87-138. Review.

PMID:
15555528
[PubMed - indexed for MEDLINE]
13.

Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1.

Charvet C, Liao WL, Heo GY, Laird J, Salomon RG, Turko IV, Pikuleva IA.

J Biol Chem. 2011 Jun 10;286(23):20413-22. doi: 10.1074/jbc.M111.232546. Epub 2011 Apr 15.

PMID:
21498512
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma.

Fourgeux C, Bron A, Acar N, Creuzot-Garcher C, Bretillon L.

Chem Phys Lipids. 2011 Sep;164(6):496-9. doi: 10.1016/j.chemphyslip.2011.04.006. Epub 2011 Apr 21. Review.

PMID:
21531213
[PubMed - indexed for MEDLINE]
15.

Expression of complement component 3 (C3) from an adenovirus leads to pathology in the murine retina.

Cashman SM, Desai A, Ramo K, Kumar-Singh R.

Invest Ophthalmol Vis Sci. 2011 May 18;52(6):3436-45. doi: 10.1167/iovs.10-6002.

PMID:
21357400
[PubMed - indexed for MEDLINE]
Free Article
16.

Retinal vascular architecture is maintained in retinal degeneration: corrosion cast and electron microscope study.

Bhutto IA, Amemiya T.

Eye (Lond). 2001 Aug;15(Pt 4):531-8.

PMID:
11767032
[PubMed - indexed for MEDLINE]
17.

Para-inflammation in the aging retina.

Xu H, Chen M, Forrester JV.

Prog Retin Eye Res. 2009 Sep;28(5):348-68. doi: 10.1016/j.preteyeres.2009.06.001. Epub 2009 Jun 26. Review.

PMID:
19560552
[PubMed - indexed for MEDLINE]
18.

Progressive dysfunction of the retinal pigment epithelium and retina due to increased VEGF-A levels.

Ablonczy Z, Dahrouj M, Marneros AG.

FASEB J. 2014 May;28(5):2369-79. doi: 10.1096/fj.13-248021. Epub 2014 Feb 20.

PMID:
24558195
[PubMed - indexed for MEDLINE]
19.

Cytochrome P450 and gene activation--from pharmacology to cholesterol elimination and regression of atherosclerosis.

Luoma PV.

Eur J Clin Pharmacol. 2008 Sep;64(9):841-50. doi: 10.1007/s00228-008-0515-5. Epub 2008 Jul 17. Review.

PMID:
18633604
[PubMed - indexed for MEDLINE]
20.

Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain.

Mast N, Reem R, Bederman I, Huang S, DiPatre PL, Bjorkhem I, Pikuleva IA.

Invest Ophthalmol Vis Sci. 2011 Feb 1;52(1):594-603. doi: 10.1167/iovs.10-6021. Print 2011 Jan.

PMID:
20881306
[PubMed - indexed for MEDLINE]
Free PMC Article

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