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Results: 1 to 20 of 101

1.

Further molecular characterisation of the OVT73 transgenic sheep model of Huntington's disease identifies cortical aggregates.

Huntington's Disease Sheep Collaborative Research Group, Reid SJ, Patassini S, Handley RR, Rudiger SR, McLaughlan CJ, Osmand A, Jacobsen JC, Morton AJ, Weiss A, Waldvogel HJ, MacDonald ME, Gusella JF, Bawden CS, Faull RL, Snell RG.

J Huntingtons Dis. 2013;2(3):279-95. doi: 10.3233/JHD-130067.

PMID:
25062676
[PubMed - indexed for MEDLINE]
2.

An ovine transgenic Huntington's disease model.

Jacobsen JC, Bawden CS, Rudiger SR, McLaughlan CJ, Reid SJ, Waldvogel HJ, MacDonald ME, Gusella JF, Walker SK, Kelly JM, Webb GC, Faull RL, Rees MI, Snell RG.

Hum Mol Genet. 2010 May 15;19(10):1873-82. doi: 10.1093/hmg/ddq063. Epub 2010 Feb 13.

PMID:
20154343
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.

Reddy PH, Charles V, Williams M, Miller G, Whetsell WO Jr, Tagle DA.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1035-45.

PMID:
10434303
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.

DiFiglia M, Sena-Esteves M, Chase K, Sapp E, Pfister E, Sass M, Yoder J, Reeves P, Pandey RK, Rajeev KG, Manoharan M, Sah DW, Zamore PD, Aronin N.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17204-9. Epub 2007 Oct 16.

PMID:
17940007
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Towards a transgenic model of Huntington's disease in a non-human primate.

Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH, Li XJ, Chan AW.

Nature. 2008 Jun 12;453(7197):921-4. doi: 10.1038/nature06975. Epub 2008 May 18.

PMID:
18488016
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.

Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM.

Neurobiol Dis. 2006 Feb;21(2):381-91. Epub 2005 Sep 16.

PMID:
16150600
[PubMed - indexed for MEDLINE]
7.

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.

Menalled LB, Sison JD, Dragatsis I, Zeitlin S, Chesselet MF.

J Comp Neurol. 2003 Oct 6;465(1):11-26.

PMID:
12926013
[PubMed - indexed for MEDLINE]
8.

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM.

Cell Death Differ. 2004 Apr;11(4):424-38.

PMID:
14713958
[PubMed - indexed for MEDLINE]
Free Article
9.

Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice.

Spires TL, Grote HE, Garry S, Cordery PM, Van Dellen A, Blakemore C, Hannan AJ.

Eur J Neurosci. 2004 May;19(10):2799-807.

PMID:
15147313
[PubMed - indexed for MEDLINE]
10.

Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice.

Gharami K, Xie Y, An JJ, Tonegawa S, Xu B.

J Neurochem. 2008 Apr;105(2):369-79. Epub 2007 Dec 12.

PMID:
18086127
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration.

Dong X, Zong S, Witting A, Lindenberg KS, Kochanek S, Huang B.

J Gene Med. 2012 Jul;14(7):468-81. doi: 10.1002/jgm.2641.

PMID:
22700462
[PubMed - indexed for MEDLINE]
12.

Alpha-synuclein immunoreactivity of huntingtin polyglutamine aggregates in striatum and cortex of Huntington's disease patients and transgenic mouse models.

Charles V, Mezey E, Reddy PH, Dehejia A, Young TA, Polymeropoulos MH, Brownstein MJ, Tagle DA.

Neurosci Lett. 2000 Jul 28;289(1):29-32.

PMID:
10899401
[PubMed - indexed for MEDLINE]
13.

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Murphy Z, Slow EJ, Leavitt BR, Hayden MR.

Hum Mol Genet. 2005 Dec 15;14(24):3823-35. Epub 2005 Nov 8.

PMID:
16278236
[PubMed - indexed for MEDLINE]
Free Article
14.

Pathogenic cellular phenotypes are germline transmissible in a transgenic primate model of Huntington's disease.

Putkhao K, Kocerha J, Cho IK, Yang J, Parnpai R, Chan AW.

Stem Cells Dev. 2013 Apr 15;22(8):1198-205. doi: 10.1089/scd.2012.0469. Epub 2013 Jan 15.

PMID:
23190281
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length.

Becher MW, Kotzuk JA, Sharp AH, Davies SW, Bates GP, Price DL, Ross CA.

Neurobiol Dis. 1998 Apr;4(6):387-97.

PMID:
9666478
[PubMed - indexed for MEDLINE]
16.

A transgenic minipig model of Huntington's Disease.

Baxa M, Hruska-Plochan M, Juhas S, Vodicka P, Pavlok A, Juhasova J, Miyanohara A, Nejime T, Klima J, Macakova M, Marsala S, Weiss A, Kubickova S, Musilova P, Vrtel R, Sontag EM, Thompson LM, Schier J, Hansikova H, Howland DS, Cattaneo E, DiFiglia M, Marsala M, Motlik J.

J Huntingtons Dis. 2013;2(1):47-68. doi: 10.3233/JHD-130001.

PMID:
25063429
[PubMed - indexed for MEDLINE]
17.

R6/2 neurons with intranuclear inclusions survive for prolonged periods in the brains of chimeric mice.

Reiner A, Del Mar N, Deng YP, Meade CA, Sun Z, Goldowitz D.

J Comp Neurol. 2007 Dec 20;505(6):603-29.

PMID:
17948889
[PubMed - indexed for MEDLINE]
18.

The selective vulnerability of nerve cells in Huntington's disease.

Sieradzan KA, Mann DM.

Neuropathol Appl Neurobiol. 2001 Feb;27(1):1-21. Review.

PMID:
11298997
[PubMed - indexed for MEDLINE]
19.

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.

Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I.

Neurobiol Dis. 2008 Jul;31(1):80-8. doi: 10.1016/j.nbd.2008.03.010. Epub 2008 Apr 16.

PMID:
18502655
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.

Gabery S, Sajjad MU, Hult S, Soylu R, Kirik D, Petersén Å.

Eur J Neurosci. 2012 Sep;36(6):2789-800. doi: 10.1111/j.1460-9568.2012.08193.x. Epub 2012 Jun 25.

PMID:
22731249
[PubMed - indexed for MEDLINE]

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