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Pleomorphic adenoma gene 1 mediates the role of karyopherin alpha 2 and has prognostic significance in hepatocellular carcinoma.

Hu ZY, Yuan SX, Yang Y, Zhou WP, Jiang H.

J Exp Clin Cancer Res. 2014 Jul 25;33:61. doi: 10.1186/s13046-014-0061-1.


Aberrant expression of nuclear KPNA2 is correlated with early recurrence and poor prognosis in patients with small hepatocellular carcinoma after hepatectomy.

Jiang P, Tang Y, He L, Tang H, Liang M, Mai C, Hu L, Hong J.

Med Oncol. 2014 Aug;31(8):131. doi: 10.1007/s12032-014-0131-4. Epub 2014 Jul 17.


Nuclear karyopherin-α2 expression in primary lesions and metastatic lymph nodes was associated with poor prognosis and progression in gastric cancer.

Altan B, Yokobori T, Mochiki E, Ohno T, Ogata K, Ogawa A, Yanai M, Kobayashi T, Luvsandagva B, Asao T, Kuwano H.

Carcinogenesis. 2013 Oct;34(10):2314-21. doi: 10.1093/carcin/bgt214. Epub 2013 Jun 8.


KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer.

Alshareeda AT, Negm OH, Green AR, Nolan CC, Tighe P, Albarakati N, Sultana R, Madhusudan S, Ellis IO, Rakha EA.

Br J Cancer. 2015 Jun 9;112(12):1929-37. doi: 10.1038/bjc.2015.165. Epub 2015 May 19.


Quantitative proteomics reveals regulation of karyopherin subunit alpha-2 (KPNA2) and its potential novel cargo proteins in nonsmall cell lung cancer.

Wang CI, Chien KY, Wang CL, Liu HP, Cheng CC, Chang YS, Yu JS, Yu CJ.

Mol Cell Proteomics. 2012 Nov;11(11):1105-22. doi: 10.1074/mcp.M111.016592. Epub 2012 Jul 25.


Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal.

Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML.

J Biol Chem. 2002 May 31;277(22):19673-8. Epub 2002 Mar 6.


Downregulation of KPNA2 in non-small-cell lung cancer is associated with Oct4 expression.

Li XL, Jia LL, Shi MM, Li X, Li ZH, Li HF, Wang EH, Jia XS.

J Transl Med. 2013 Sep 26;11:232. doi: 10.1186/1479-5876-11-232.


Importin-α1 as a novel prognostic target for hepatocellular carcinoma.

Yoshitake K, Tanaka S, Mogushi K, Aihara A, Murakata A, Matsumura S, Mitsunori Y, Yasen M, Ban D, Noguchi N, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S.

Ann Surg Oncol. 2011 Jul;18(7):2093-103. doi: 10.1245/s10434-011-1569-7. Epub 2011 Feb 1.


KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a.

Huang L, Wang HY, Li JD, Wang JH, Zhou Y, Luo RZ, Yun JP, Zhang Y, Jia WH, Zheng M.

Cell Death Dis. 2013 Aug 1;4:e745. doi: 10.1038/cddis.2013.256.


High nuclear karyopherin α 2 expression is a strong and independent predictor of biochemical recurrence in prostate cancer patients treated by radical prostatectomy.

Grupp K, Habermann M, Sirma H, Simon R, Steurer S, Hube-Magg C, Prien K, Burkhardt L, Jedrzejewska K, Salomon G, Heinzer H, Wilczak W, Kluth M, Izbicki JR, Sauter G, Minner S, Schlomm T, Tsourlakis MC.

Mod Pathol. 2014 Jan;27(1):96-106. doi: 10.1038/modpathol.2013.127. Epub 2013 Jul 26.


Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma.

Sakai M, Sohda M, Miyazaki T, Suzuki S, Sano A, Tanaka N, Inose T, Nakajima M, Kato H, Kuwano H.

Anticancer Res. 2010 Mar;30(3):851-6.


Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2.

Tan S, Ding K, Li R, Zhang W, Li G, Kong X, Qian P, Lobie PE, Zhu T.

Breast Cancer Res. 2014 Apr 15;16(2):R40. doi: 10.1186/bcr3644.


Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosis.

He L, Ding H, Wang JH, Zhou Y, Li L, Yu YH, Huang L, Jia WH, Zeng M, Yun JP, Luo RZ, Zheng M.

PLoS One. 2012;7(9):e42992. doi: 10.1371/journal.pone.0042992. Epub 2012 Sep 4.


CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery.

Yang XR, Xu Y, Yu B, Zhou J, Li JC, Qiu SJ, Shi YH, Wang XY, Dai Z, Shi GM, Wu B, Wu LM, Yang GH, Zhang BH, Qin WX, Fan J.

Clin Cancer Res. 2009 Sep 1;15(17):5518-27. doi: 10.1158/1078-0432.CCR-09-0151. Epub 2009 Aug 25.


Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity.

Gluz O, Wild P, Meiler R, Diallo-Danebrock R, Ting E, Mohrmann S, Schuett G, Dahl E, Fuchs T, Herr A, Gaumann A, Frick M, Poremba C, Nitz UA, Hartmann A.

Int J Cancer. 2008 Sep 15;123(6):1433-8. doi: 10.1002/ijc.23628.


Myeloid differentiation factor 88 promotes growth and metastasis of human hepatocellular carcinoma.

Liang B, Chen R, Wang T, Cao L, Liu Y, Yin F, Zhu M, Fan X, Liang Y, Zhang L, Guo Y, Zhao J.

Clin Cancer Res. 2013 Jun 1;19(11):2905-16. doi: 10.1158/1078-0432.CCR-12-1245. Epub 2013 Apr 2.


Expression and prognostic significance of vascular endothelial growth factor receptor 1 in hepatocellular carcinoma.

Li T, Zhu Y, Qin CY, Yang Z, Fang A, Xu S, Ren W.

J Clin Pathol. 2012 Sep;65(9):808-14. doi: 10.1136/jclinpath-2012-200721. Epub 2012 Jun 25.


Villin 1 is a predictive factor for the recurrence of high serum alpha-fetoprotein-associated hepatocellular carcinoma after hepatectomy.

Xieraili M, Yasen M, Mogushi K, Obulhasim G, Mayinuer A, Aihara A, Tanaka S, Mizushima H, Tanaka H, Arii S.

Cancer Sci. 2012 Aug;103(8):1493-501. doi: 10.1111/j.1349-7006.2012.02315.x. Epub 2012 May 25.


LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma.

Yang H, Xiong FX, Lin M, Yang Y, Nie X, Zhou RL.

J Cancer Res Clin Oncol. 2010 Feb;136(2):275-81. doi: 10.1007/s00432-009-0659-4. Epub 2009 Aug 19.


Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma.

Xia L, Huang W, Tian D, Zhu H, Zhang Y, Hu H, Fan D, Nie Y, Wu K.

J Hepatol. 2012 Sep;57(3):600-12. doi: 10.1016/j.jhep.2012.04.020. Epub 2012 May 18.

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