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Items: 1 to 20 of 99

1.

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.

Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E.

Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003.

2.

Characterization of the GRK2 binding site of Galphaq.

Day PW, Tesmer JJ, Sterne-Marr R, Freeman LC, Benovic JL, Wedegaertner PB.

J Biol Chem. 2004 Dec 17;279(51):53643-52. Epub 2004 Oct 7.

3.

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.

Nishimura A, Kitano K, Takasaki J, Taniguchi M, Mizuno N, Tago K, Hakoshima T, Itoh H.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13666-71. doi: 10.1073/pnas.1003553107. Epub 2010 Jul 16.

4.

A novel Galphaq/11-selective inhibitor.

Takasaki J, Saito T, Taniguchi M, Kawasaki T, Moritani Y, Hayashi K, Kobori M.

J Biol Chem. 2004 Nov 12;279(46):47438-45. Epub 2004 Aug 31.

5.

Strike a pose: Gαq complexes at the membrane.

Lyon AM, Taylor VG, Tesmer JJ.

Trends Pharmacol Sci. 2014 Jan;35(1):23-30. doi: 10.1016/j.tips.2013.10.008. Epub 2013 Nov 26. Review.

6.

Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A.

Chishiki K, Kamakura S, Yuzawa S, Hayase J, Sumimoto H.

Biochem Biophys Res Commun. 2013 Jun 7;435(3):414-9. doi: 10.1016/j.bbrc.2013.04.103. Epub 2013 May 9.

PMID:
23665327
7.

Inhibition of heterotrimeric G protein signaling by a small molecule acting on Galpha subunit.

Ayoub MA, Damian M, Gespach C, Ferrandis E, Lavergne O, De Wever O, Banères JL, Pin JP, Prévost GP.

J Biol Chem. 2009 Oct 16;284(42):29136-45. doi: 10.1074/jbc.M109.042333. Epub 2009 Jul 31.

8.

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.

Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ.

Science. 2005 Dec 9;310(5754):1686-90.

9.

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.

Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ.

Science. 2007 Dec 21;318(5858):1923-7.

10.

Alpha-thrombin-mediated phosphatidylinositol 3-kinase activation through release of Gbetagamma dimers from Galphaq and Galphai2.

Goel R, Phillips-Mason PJ, Gardner A, Raben DM, Baldassare JJ.

J Biol Chem. 2004 Feb 20;279(8):6701-10. Epub 2003 Dec 9.

11.

Role of Galphaq in smooth muscle cell proliferation.

Tanski WJ, Roztocil E, Hemady EA, Williams JA, Davies MG.

J Vasc Surg. 2004 Mar;39(3):639-44.

12.

Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins.

Sterne-Marr R, Dhami GK, Tesmer JJ, Ferguson SS.

Methods Enzymol. 2004;390:310-36.

PMID:
15488186
13.

G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.

Takashima S, Sugimoto N, Takuwa N, Okamoto Y, Yoshioka K, Takamura M, Takata S, Kaneko S, Takuwa Y.

Cardiovasc Res. 2008 Sep 1;79(4):689-97. doi: 10.1093/cvr/cvn118. Epub 2008 May 14.

14.

Oligomerization of wild type and nonfunctional mutant angiotensin II type I receptors inhibits galphaq protein signaling but not ERK activation.

Hansen JL, Theilade J, Haunsø S, Sheikh SP.

J Biol Chem. 2004 Jun 4;279(23):24108-15. Epub 2004 Mar 31.

15.

N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q).

Crouthamel M, Thiyagarajan MM, Evanko DS, Wedegaertner PB.

Cell Signal. 2008 Oct;20(10):1900-10. doi: 10.1016/j.cellsig.2008.06.019. Epub 2008 Jul 2.

16.

RhoA- and RhoD-dependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion.

Nguyen QD, Faivre S, Bruyneel E, Rivat C, Seto M, Endo T, Mareel M, Emami S, Gespach C.

FASEB J. 2002 Apr;16(6):565-76.

17.

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain.

Rojas RJ, Yohe ME, Gershburg S, Kawano T, Kozasa T, Sondek J.

J Biol Chem. 2007 Oct 5;282(40):29201-10. Epub 2007 Jul 2.

18.

Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq.

Sallese M, Mariggiò S, D'Urbano E, Iacovelli L, De Blasi A.

Mol Pharmacol. 2000 Apr;57(4):826-31.

19.

Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gα(s) and Gα(q) proteins.

Shiu SY, Pang B, Tam CW, Yao KM.

J Pineal Res. 2010 Oct;49(3):301-11. doi: 10.1111/j.1600-079X.2010.00795.x. Epub 2010 Aug 1.

PMID:
20695976
20.
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