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Items: 1 to 20 of 89

1.

PKCδ regulates hepatic triglyceride accumulation and insulin signaling in Lepr(db/db) mice.

Zhang J, Burrington CM, Davenport SK, Johnson AK, Horsman MJ, Chowdhry S, Greene MW.

Biochem Biophys Res Commun. 2014 Aug 8;450(4):1619-25. doi: 10.1016/j.bbrc.2014.07.048. Epub 2014 Jul 15.

PMID:
25035929
2.

Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis.

Handa P, Maliken BD, Nelson JE, Morgan-Stevenson V, Messner DJ, Dhillon BK, Klintworth HM, Beauchamp M, Yeh MM, Elfers CT, Roth CL, Kowdley KV.

Hepatology. 2014 Jul;60(1):133-45. doi: 10.1002/hep.26946. Epub 2014 May 27.

PMID:
24464605
3.

Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis.

Greene MW, Burrington CM, Lynch DT, Davenport SK, Johnson AK, Horsman MJ, Chowdhry S, Zhang J, Sparks JD, Tirrell PC.

PLoS One. 2014 Jan 15;9(1):e85848. doi: 10.1371/journal.pone.0085848. eCollection 2014.

4.

Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet.

Kondo Y, Hasegawa G, Okada H, Senmaru T, Fukui M, Nakamura N, Sawada M, Kitawaki J, Okanoue T, Kishimoto Y, Amano A, Maruyama N, Obayashi H, Ishigami A.

PLoS One. 2013 Jun 3;8(6):e65698. doi: 10.1371/journal.pone.0065698. Print 2013.

5.

Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice.

Malloy VL, Perrone CE, Mattocks DA, Ables GP, Caliendo NS, Orentreich DS, Orentreich N.

Metabolism. 2013 Nov;62(11):1651-61. doi: 10.1016/j.metabol.2013.06.012. Epub 2013 Aug 5.

PMID:
23928105
6.

CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice.

Schroeder-Gloeckler JM, Rahman SM, Janssen RC, Qiao L, Shao J, Roper M, Fischer SJ, Lowe E, Orlicky DJ, McManaman JL, Palmer C, Gitomer WL, Huang W, O'Doherty RM, Becker TC, Klemm DJ, Jensen DR, Pulawa LK, Eckel RH, Friedman JE.

J Biol Chem. 2007 May 25;282(21):15717-29. Epub 2007 Mar 26.

7.

Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.

Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM.

Hepatology. 2007 Jun;45(6):1366-74.

PMID:
17476695
8.

Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice.

Liu LF, Purushotham A, Wendel AA, Belury MA.

Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1671-82. Epub 2007 Feb 22.

9.

Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1.

Guo H, Xia M, Zou T, Ling W, Zhong R, Zhang W.

J Nutr Biochem. 2012 Apr;23(4):349-60. doi: 10.1016/j.jnutbio.2010.12.013. Epub 2011 May 2.

PMID:
21543211
10.

Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice.

Yamashita H, Shao J, Qiao L, Pagliassotti M, Friedman JE.

Pediatr Res. 2003 Mar;53(3):411-8.

PMID:
12595588
11.

A novel aminosterol reverses diabetes and fatty liver disease in obese mice.

Takahashi N, Qi Y, Patel HR, Ahima RS.

J Hepatol. 2004 Sep;41(3):391-8.

PMID:
15336441
12.

Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling.

Clementi AH, Gaudy AM, van Rooijen N, Pierce RH, Mooney RA.

Biochim Biophys Acta. 2009 Nov;1792(11):1062-72. doi: 10.1016/j.bbadis.2009.08.007. Epub 2009 Aug 20.

13.

PKCδ is activated in the liver of obese Zucker rats and mediates diet-induced whole body insulin resistance and hepatocyte cellular insulin resistance.

Greene MW, Burrington CM, Luo Y, Ruhoff MS, Lynch DT, Chaithongdi N.

J Nutr Biochem. 2014 Mar;25(3):281-8. doi: 10.1016/j.jnutbio.2013.10.008. Epub 2013 Nov 15.

PMID:
24524901
14.

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.

de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM, Chua SC Jr.

J Clin Invest. 2005 Dec;115(12):3484-93. Epub 2005 Nov 10.

15.

Mouse KLF11 regulates hepatic lipid metabolism.

Zhang H, Chen Q, Yang M, Zhu B, Cui Y, Xue Y, Gong N, Cui A, Wang M, Shen L, Zhang S, Fang F, Chang Y.

J Hepatol. 2013 Apr;58(4):763-70. doi: 10.1016/j.jhep.2012.11.024. Epub 2012 Nov 23.

PMID:
23183531
16.

Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis.

Kuo JJ, Chang HH, Tsai TH, Lee TY.

Int J Mol Med. 2012 Sep;30(3):673-9. doi: 10.3892/ijmm.2012.1049. Epub 2012 Jun 29.

PMID:
22751848
17.

Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats.

Shen L, Liu Z, Gong J, Zhang L, Wang L, Magdalou J, Chen L, Wang H.

Toxicol Appl Pharmacol. 2014 Jan 15;274(2):263-73. doi: 10.1016/j.taap.2013.11.009. Epub 2013 Nov 22.

PMID:
24275070
18.

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.

Bijl N, Sokolović M, Vrins C, Langeveld M, Moerland PD, Ottenhoff R, van Roomen CP, Claessen N, Boot RG, Aten J, Groen AK, Aerts JM, van Eijk M.

Hepatology. 2009 Nov;50(5):1431-41. doi: 10.1002/hep.23175.

PMID:
19731235
19.

Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice.

Yang J, Park Y, Zhang H, Xu X, Laine GA, Dellsperger KC, Zhang C.

Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1850-8. doi: 10.1152/ajpheart.01199.2008. Epub 2009 Apr 10.

20.

Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice.

Tamura Y, Sugimoto M, Murayama T, Ueda Y, Kanamori H, Ono K, Ariyasu H, Akamizu T, Kita T, Yokode M, Arai H.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2195-201. doi: 10.1161/ATVBAHA.108.168633. Epub 2008 Sep 25.

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