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Items: 1 to 20 of 98


Binding of the extreme carboxyl-terminus of PAK-interacting exchange factor β (βPIX) to myosin 18A (MYO18A) is required for epithelial cell migration.

Hsu RM, Hsieh YJ, Yang TH, Chiang YC, Kan CY, Lin YT, Chen JT, Yu JS.

Biochim Biophys Acta. 2014 Nov;1843(11):2513-27. doi: 10.1016/j.bbamcr.2014.06.023. Epub 2014 Jul 8.


Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration.

Hsu RM, Tsai MH, Hsieh YJ, Lyu PC, Yu JS.

Mol Biol Cell. 2010 Jan 15;21(2):287-301. doi: 10.1091/mbc.E09-03-0232. Epub 2009 Nov 18.


A βPIX-PAK2 complex confers protection against Scrib-dependent and cadherin-mediated apoptosis.

Frank SR, Bell JH, Frödin M, Hansen SH.

Curr Biol. 2012 Oct 9;22(19):1747-54. doi: 10.1016/j.cub.2012.07.011. Epub 2012 Aug 2.


GIT1/βPIX signaling proteins and PAK1 kinase regulate microtubule nucleation.

Černohorská M, Sulimenko V, Hájková Z, Sulimenko T, Sládková V, Vinopal S, Dráberová E, Dráber P.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1282-97. doi: 10.1016/j.bbamcr.2016.03.016. Epub 2016 Mar 22.


Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth.

Shin EY, Shin KS, Lee CS, Woo KN, Quan SH, Soung NK, Kim YG, Cha CI, Kim SR, Park D, Bokoch GM, Kim EG.

J Biol Chem. 2002 Nov 15;277(46):44417-30. Epub 2002 Sep 10.


Characterization of the endogenous GIT1-betaPIX complex, and identification of its association to membranes.

Botrugno OA, Paris S, Za L, Gualdoni S, Cattaneo A, Bachi A, de Curtis I.

Eur J Cell Biol. 2006 Jan;85(1):35-46. Epub 2005 Nov 8.


Identification of an intramolecular interaction important for the regulation of GIT1 functions.

Totaro A, Paris S, Asperti C, de Curtis I.

Mol Biol Cell. 2007 Dec;18(12):5124-38. Epub 2007 Sep 26.


GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover.

Frank SR, Adelstein MR, Hansen SH.

EMBO J. 2006 May 3;25(9):1848-59. Epub 2006 Apr 20.


Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly.

Zhao ZS, Manser E, Loo TH, Lim L.

Mol Cell Biol. 2000 Sep;20(17):6354-63.


p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase.

Lee J, Jung ID, Chang WK, Park CG, Cho DY, Shin EY, Seo DW, Kim YK, Lee HW, Han JW, Lee HY.

Exp Cell Res. 2005 Jul 15;307(2):315-28.


BetaPix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling.

Lee SH, Eom M, Lee SJ, Kim S, Park HJ, Park D.

J Biol Chem. 2001 Jul 6;276(27):25066-72. Epub 2001 Apr 17.


βPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin αvβ8.

Liu J, Zeng L, Kennedy RM, Gruenig NM, Childs SJ.

Dev Biol. 2012 Mar 1;363(1):95-105. doi: 10.1016/j.ydbio.2011.12.022. Epub 2011 Dec 22.


Microtubule nucleation in mouse bone marrow-derived mast cells is regulated by the concerted action of GIT1/βPIX proteins and calcium.

Sulimenko V, Hájková Z, Černohorská M, Sulimenko T, Sládková V, Dráberová L, Vinopal S, Dráberová E, Dráber P.

J Immunol. 2015 May 1;194(9):4099-111. doi: 10.4049/jimmunol.1402459. Epub 2015 Mar 27.


betaPIX controls cell motility and neurite extension by regulating the distribution of GIT1.

Za L, Albertinazzi C, Paris S, Gagliani M, Tacchetti C, de Curtis I.

J Cell Sci. 2006 Jul 1;119(Pt 13):2654-66.


FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX.

Chang F, Lemmon CA, Park D, Romer LH.

Mol Biol Cell. 2007 Jan;18(1):253-64. Epub 2006 Nov 8.


GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration.

Manabe R, Kovalenko M, Webb DJ, Horwitz AR.

J Cell Sci. 2002 Apr 1;115(Pt 7):1497-510.


GIT1 paxillin-binding domain is a four-helix bundle, and it binds to both paxillin LD2 and LD4 motifs.

Zhang ZM, Simmerman JA, Guibao CD, Zheng JJ.

J Biol Chem. 2008 Jul 4;283(27):18685-93. doi: 10.1074/jbc.M801274200. Epub 2008 Apr 30.


GIT1 is a novel MEK1-ERK1/2 scaffold that localizes to focal adhesions.

Zhang N, Cai W, Yin G, Nagel DJ, Berk BC.

Cell Biol Int. 2009 Dec 16;34(1):41-7. doi: 10.1042/CBI20090016.

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