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Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice.

Cai A, Hutchison E, Hudson J, Kawashima Y, Komori N, Singh A, Brush RS, Anderson RE, Sonntag WE, Matsumoto H, Griffin TM.

Osteoarthritis Cartilage. 2014 Sep;22(9):1301-9. doi: 10.1016/j.joca.2014.06.033. Epub 2014 Jul 4.


Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study.

Baker KR, Matthan NR, Lichtenstein AH, Niu J, Guermazi A, Roemer F, Grainger A, Nevitt MC, Clancy M, Lewis CE, Torner JC, Felson DT.

Osteoarthritis Cartilage. 2012 May;20(5):382-7. doi: 10.1016/j.joca.2012.01.021. Epub 2012 Feb 4.


Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice.

Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC.

Ann Rheum Dis. 2014 Sep;73(9):1719-27. doi: 10.1136/annrheumdis-2013-203231. Epub 2013 Jul 12.


Statins and fibrates do not affect development of spontaneous cartilage damage in STR/Ort mice.

Wei W, Clockaerts S, Bastiaansen-Jenniskens YM, Gierman LM, Botter SM, Bierma-Zeinstra SM, Weinans H, Verhaar JA, Kloppenburg M, Zuurmond AM, van Osch GJ.

Osteoarthritis Cartilage. 2014 Feb;22(2):293-301. doi: 10.1016/j.joca.2013.11.009. Epub 2013 Nov 23.


Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and cartilage degradation of the tibia, bone/cartilage turnover, and joint discomfort.

Mohan G, Perilli E, Parkinson IH, Humphries JM, Fazzalari NL, Kuliwaba JS.

Osteoarthritis Cartilage. 2013 Oct;21(10):1595-604. doi: 10.1016/j.joca.2013.06.020. Epub 2013 Jul 1.


Dietary ratio of n-6/n-3 PUFAs and docosahexaenoic acid: actions on bone mineral and serum biomarkers in ovariectomized rats.

Watkins BA, Li Y, Seifert MF.

J Nutr Biochem. 2006 Apr;17(4):282-9. Epub 2005 Jun 21.


A high ratio of dietary n-3/n-6 polyunsaturated fatty acids improves obesity-linked inflammation and insulin resistance through suppressing activation of TLR4 in SD rats.

Liu HQ, Qiu Y, Mu Y, Zhang XJ, Liu L, Hou XH, Zhang L, Xu XN, Ji AL, Cao R, Yang RH, Wang F.

Nutr Res. 2013 Oct;33(10):849-58. doi: 10.1016/j.nutres.2013.07.004. Epub 2013 Aug 9.


Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.

Zainal Z, Longman AJ, Hurst S, Duggan K, Caterson B, Hughes CE, Harwood JL.

Osteoarthritis Cartilage. 2009 Jul;17(7):896-905. doi: 10.1016/j.joca.2008.12.009. Epub 2009 Jan 13.


Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus.

Sondergaard BC, Catala-Lehnen P, Huebner AK, Bay-Jensen AC, Schinke T, Henriksen K, Schilling S, Haberland M, Nielsen RH, Amling M, Karsdal MA.

Osteoarthritis Cartilage. 2012 Feb;20(2):136-43. doi: 10.1016/j.joca.2011.11.004. Epub 2011 Nov 13.


Effect of interval-training exercise on subchondral bone in a chemically-induced osteoarthritis model.

Boudenot A, Presle N, Uzbekov R, Toumi H, Pallu S, Lespessailles E.

Osteoarthritis Cartilage. 2014 Aug;22(8):1176-85. doi: 10.1016/j.joca.2014.05.020. Epub 2014 Jun 10.


ADAMTS5-/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes.

Botter SM, Glasson SS, Hopkins B, Clockaerts S, Weinans H, van Leeuwen JP, van Osch GJ.

Osteoarthritis Cartilage. 2009 May;17(5):636-45. doi: 10.1016/j.joca.2008.09.018. Epub 2008 Oct 17.


In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis.

Valverde-Franco G, Pelletier JP, Fahmi H, Hum D, Matsuo K, Lussier B, Kapoor M, Martel-Pelletier J.

Arthritis Rheum. 2012 Nov;64(11):3614-25. doi: 10.1002/art.34638.


Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritis.

Wang Y, Wluka AE, Hodge AM, English DR, Giles GG, O'Sullivan R, Cicuttini FM.

Osteoarthritis Cartilage. 2008 May;16(5):579-83. Epub 2007 Oct 15.


Regulation of osteoarthritis by omega-3 (n-3) polyunsaturated fatty acids in a naturally occurring model of disease.

Knott L, Avery NC, Hollander AP, Tarlton JF.

Osteoarthritis Cartilage. 2011 Sep;19(9):1150-7. doi: 10.1016/j.joca.2011.06.005. Epub 2011 Jul 1.


Elevated tissue omega-3 fatty acid status prevents age-related glucose intolerance in fat-1 transgenic mice.

Romanatto T, Fiamoncini J, Wang B, Curi R, Kang JX.

Biochim Biophys Acta. 2014 Feb;1842(2):186-91. doi: 10.1016/j.bbadis.2013.10.017. Epub 2013 Nov 7.


Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.

Curtis CL, Rees SG, Little CB, Flannery CR, Hughes CE, Wilson C, Dent CM, Otterness IG, Harwood JL, Caterson B.

Arthritis Rheum. 2002 Jun;46(6):1544-53. Retraction in: Caterson B. Arthritis Rheum. 2006 Sep;54(9):2933.


Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis.

Wang T, Wen CY, Yan CH, Lu WW, Chiu KY.

Osteoarthritis Cartilage. 2013 Apr;21(4):574-81. doi: 10.1016/j.joca.2013.01.002. Epub 2013 Jan 9.


Cox-2 expression, PGE(2) and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice.

Gravaghi C, La Perle KM, Ogrodwski P, Kang JX, Quimby F, Lipkin M, Lamprecht SA.

J Nutr Biochem. 2011 Apr;22(4):360-5. doi: 10.1016/j.jnutbio.2010.03.003. Epub 2010 Jul 23.


Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging.

de Hooge AS, van de Loo FA, Bennink MB, Arntz OJ, de Hooge P, van den Berg WB.

Osteoarthritis Cartilage. 2005 Jan;13(1):66-73.


Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the IL-17/IL-23 axis.

Qin S, Wen J, Bai XC, Chen TY, Zheng RC, Zhou GB, Ma J, Feng JY, Zhong BL, Li YM.

Mol Med Rep. 2014 Jun;9(6):2097-104. doi: 10.3892/mmr.2014.2136. Epub 2014 Apr 9.

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