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IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt.

Li H, Hsu HC, Wu Q, Yang P, Li J, Luo B, Oukka M, Steele CH 3rd, Cua DJ, Grizzle WE, Mountz JD.

Nat Commun. 2014 Jul 8;5:4259. doi: 10.1038/ncomms5259.


The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus.

Tao W, Teh SJ, Melhado I, Jirik F, Korsmeyer SJ, Teh HS.

J Exp Med. 1994 Jan 1;179(1):145-53.


Interleukin-22 drives endogenous thymic regeneration in mice.

Dudakov JA, Hanash AM, Jenq RR, Young LF, Ghosh A, Singer NV, West ML, Smith OM, Holland AM, Tsai JJ, Boyd RL, van den Brink MR.

Science. 2012 Apr 6;336(6077):91-5. doi: 10.1126/science.1218004. Epub 2012 Mar 1.


T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.

Wang R, Xie H, Huang Z, Ma J, Fang X, Ding Y, Sun Z.

J Immunol. 2011 Dec 1;187(11):5964-73. doi: 10.4049/jimmunol.1101205. Epub 2011 Oct 28.


Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes.

Rafei M, Rouette A, Brochu S, Vanegas JR, Perreault C.

Blood. 2013 Jan 3;121(1):107-17. doi: 10.1182/blood-2012-05-433508. Epub 2012 Oct 4.


A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection.

Bassiri H, Carding SR.

J Immunol. 2001 May 15;166(10):5945-54.


Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion.

Rachitskaya AV, Hansen AM, Horai R, Li Z, Villasmil R, Luger D, Nussenblatt RB, Caspi RR.

J Immunol. 2008 Apr 15;180(8):5167-71.


Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

Zhou T, Cheng J, Yang P, Wang Z, Liu C, Su X, Bluethmann H, Mountz JD.

J Exp Med. 1996 Apr 1;183(4):1879-92.


Examination of thymic positive and negative selection by flow cytometry.

Hu Q, Nicol SA, Suen AY, Baldwin TA.

J Vis Exp. 2012 Oct 8;(68). pii: 4269. doi: 10.3791/4269.


Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice.

Teh HS, Kishi H, Scott B, Borgulya P, von Boehmer H, Kisielow P.

Dev Immunol. 1990;1(1):1-10.


Cytokine production by mature and immature CD4-CD8- T cells. Alpha beta-T cell receptor+ CD4-CD8- T cells produce IL-4.

Zlotnik A, Godfrey DI, Fischer M, Suda T.

J Immunol. 1992 Aug 15;149(4):1211-5.


Interleukin-7 supports survival of T-cell receptor-β-expressing CD4(-) CD8(-) double-negative thymocytes.

Xiong J, Parker BL, Dalheimer SL, Yankee TM.

Immunology. 2013 Apr;138(4):382-91. doi: 10.1111/imm.12050.


CD3-induced apoptosis of CD4+CD8+ thymocytes in the absence of clonotypic T cell antigen receptor.

Tokoro Y, Tsuda S, Tanaka S, Nakauchi H, Takahama Y.

Eur J Immunol. 1996 May;26(5):1012-7.

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