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Results: 1 to 20 of 112

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1.

Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis.

Weng T, Xie Y, Yi L, Huang J, Luo F, Du X, Chen L, Liu C, Chen D, Chen L.

Osteoarthritis Cartilage. 2014 Aug;22(8):1197-205. doi: 10.1016/j.joca.2014.06.031. Epub 2014 Jul 4.

2.

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice.

Matsuzaki T, Matsushita T, Takayama K, Matsumoto T, Nishida K, Kuroda R, Kurosaka M.

Ann Rheum Dis. 2014 Jul;73(7):1397-404. doi: 10.1136/annrheumdis-2012-202620. Epub 2013 May 30.

PMID:
23723318
3.

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice.

Weng T, Yi L, Huang J, Luo F, Wen X, Du X, Chen Q, Deng C, Chen D, Chen L.

Arthritis Rheum. 2012 Dec;64(12):3982-92. doi: 10.1002/art.34645.

4.

NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis.

Yang S, Ryu JH, Oh H, Jeon J, Kwak JS, Kim JH, Kim HA, Chun CH, Chun JS.

Ann Rheum Dis. 2015 Mar;74(3):595-602. doi: 10.1136/annrheumdis-2013-204355. Epub 2013 Dec 17.

5.

Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction.

Ryu JH, Shin Y, Huh YH, Yang S, Chun CH, Chun JS.

Cell Death Differ. 2012 Mar;19(3):440-50. doi: 10.1038/cdd.2011.111. Epub 2011 Aug 26.

6.

Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis.

Yudoh K, Nakamura H, Masuko-Hongo K, Kato T, Nishioka K.

Arthritis Res Ther. 2005;7(4):R904-14. Epub 2005 May 27. Erratum in: Arthritis Res Ther. 2005;7(5):225.

7.

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice.

Ryu JH, Yang S, Shin Y, Rhee J, Chun CH, Chun JS.

Arthritis Rheum. 2011 Sep;63(9):2732-43. doi: 10.1002/art.30451.

8.

Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis.

Akasaki Y, Hasegawa A, Saito M, Asahara H, Iwamoto Y, Lotz MK.

Osteoarthritis Cartilage. 2014 Jan;22(1):162-70. doi: 10.1016/j.joca.2013.11.004. Epub 2013 Nov 21.

9.

Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis.

Shimizu S, Asou Y, Itoh S, Chung UI, Kawaguchi H, Shinomiya K, Muneta T.

Arthritis Rheum. 2007 Oct;56(10):3358-65.

10.

Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma.

Osada R, Horiuchi A, Kikuchi N, Yoshida J, Hayashi A, Ota M, Katsuyama Y, Melillo G, Konishi I.

Hum Pathol. 2007 Sep;38(9):1310-20. Epub 2007 Jun 6. Erratum in: Hum Pathol. 2008 Jan;39(1):147. Mellilo, Giovanni [corrected to Melillo, Giovanni].

PMID:
17555795
11.

Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints.

Gelse K, Pfander D, Obier S, Knaup KX, Wiesener M, Hennig FF, Swoboda B.

Arthritis Res Ther. 2008;10(5):R111. doi: 10.1186/ar2508. Epub 2008 Sep 12.

12.

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage.

Vasheghani F, Zhang Y, Li YH, Blati M, Fahmi H, Lussier B, Roughley P, Lagares D, Endisha H, Saffar B, Lajeunesse D, Marshall WK, Rampersaud YR, Mahomed NN, Gandhi R, Pelletier JP, Martel-Pelletier J, Kapoor M.

Ann Rheum Dis. 2015 Mar;74(3):569-78. doi: 10.1136/annrheumdis-2014-205743. Epub 2015 Jan 8.

13.

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.

Blom AB, Brockbank SM, van Lent PL, van Beuningen HM, Geurts J, Takahashi N, van der Kraan PM, van de Loo FA, Schreurs BW, Clements K, Newham P, van den Berg WB.

Arthritis Rheum. 2009 Feb;60(2):501-12. doi: 10.1002/art.24247.

14.

Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes.

Coimbra IB, Jimenez SA, Hawkins DF, Piera-Velazquez S, Stokes DG.

Osteoarthritis Cartilage. 2004 Apr;12(4):336-45.

PMID:
15023385
15.

Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints.

Weng LH, Ko JY, Wang CJ, Sun YC, Wang FS.

Arthritis Rheum. 2012 Oct;64(10):3267-77. doi: 10.1002/art.34602.

17.

Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.

Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E.

Dev Biol. 2014 Sep 1;393(1):124-36. doi: 10.1016/j.ydbio.2014.06.013. Epub 2014 Jun 24.

PMID:
24972088
18.

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees.

Weng LH, Wang CJ, Ko JY, Sun YC, Wang FS.

Arthritis Rheum. 2010 May;62(5):1393-402. doi: 10.1002/art.27357.

19.
20.

Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice.

Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC.

Ann Rheum Dis. 2014 Sep;73(9):1719-27. doi: 10.1136/annrheumdis-2013-203231. Epub 2013 Jul 12.

PMID:
23852692
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