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RHBDL2 is a critical membrane protease for anoikis resistance in human malignant epithelial cells.

Cheng TL, Lai CH, Jiang SJ, Hung JH, Liu SK, Chang BI, Shi GY, Wu HL.

ScientificWorldJournal. 2014;2014:902987. doi: 10.1155/2014/902987. Epub 2014 May 28.


Mammalian EGF receptor activation by the rhomboid protease RHBDL2.

Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M.

EMBO Rep. 2011 May;12(5):421-7. doi: 10.1038/embor.2011.50. Epub 2011 Apr 15.


The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity.

Lei X, Li YM.

J Mol Biol. 2009 Dec 18;394(5):815-25. doi: 10.1016/j.jmb.2009.10.025. Epub 2009 Oct 20.


Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2.

Pascall JC, Brown KD.

Biochem Biophys Res Commun. 2004 Apr 23;317(1):244-52.


Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis.

Rafiq K, Hanscom M, Valerie K, Steinberg SF, Sabri A.

Circ Res. 2008 Jan 4;102(1):32-41. Epub 2007 Nov 1.


LIP expression is regulated by IGF-1R signaling and participates in suppression of anoikis.

Li H, Baldwin BR, Zahnow CA.

Mol Cancer. 2011 Aug 19;10:100. doi: 10.1186/1476-4598-10-100.


Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells.

He X, Ota T, Liu P, Su C, Chien J, Shridhar V.

Cancer Res. 2010 Apr 15;70(8):3109-18. doi: 10.1158/0008-5472.CAN-09-3557. Epub 2010 Apr 13.


Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals.

Giannoni E, Fiaschi T, Ramponi G, Chiarugi P.

Oncogene. 2009 May 21;28(20):2074-86. doi: 10.1038/onc.2009.77. Epub 2009 Apr 20.


SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells.

Lauricella M, Ciraolo A, Carlisi D, Vento R, Tesoriere G.

Biochimie. 2012 Feb;94(2):287-99. doi: 10.1016/j.biochi.2011.06.031. Epub 2011 Jul 31.


Anoikis molecular pathways and its role in cancer progression.

Paoli P, Giannoni E, Chiarugi P.

Biochim Biophys Acta. 2013 Dec;1833(12):3481-98. doi: 10.1016/j.bbamcr.2013.06.026. Epub 2013 Jul 2. Review.


G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression.

Collins NL, Reginato MJ, Paulus JK, Sgroi DC, Labaer J, Brugge JS.

Mol Cell Biol. 2005 Jun;25(12):5282-91.


EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activities.

Quadros MR, Connelly S, Kari C, Abrams MT, Wickstrom E, Rodeck U.

Cancer Biol Ther. 2006 May;5(5):498-504. Epub 2006 May 6.


Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis.

Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS.

Nat Cell Biol. 2003 Aug;5(8):733-40.


ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation.

Liu Z, Li H, Derouet M, Filmus J, LaCasse EC, Korneluk RG, Kerbel RS, Rosen KV.

J Biol Chem. 2005 Nov 11;280(45):37383-92. Epub 2005 Aug 22.


Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing.

Cheng TL, Wu YT, Lin HY, Hsu FC, Liu SK, Chang BI, Chen WS, Lai CH, Shi GY, Wu HL.

J Invest Dermatol. 2011 Dec;131(12):2486-94. doi: 10.1038/jid.2011.230. Epub 2011 Aug 11.


Epithelial mesenchymal transition is required for acquisition of anoikis resistance and metastatic potential in adenoid cystic carcinoma.

Jia J, Zhang W, Liu JY, Chen G, Liu H, Zhong HY, Liu B, Cai Y, Zhang JL, Zhao YF.

PLoS One. 2012;7(12):e51549. doi: 10.1371/journal.pone.0051549. Epub 2012 Dec 14. Retraction in: PLoS One. 2014;9(9):e108117.


N-acetylglucosaminyltransferase V confers hepatoma cells with resistance to anoikis through EGFR/PAK1 activation.

Liu J, Liu H, Zhang W, Wu Q, Liu W, Liu Y, Pan D, Xu J, Gu J.

Glycobiology. 2013 Sep;23(9):1097-109. doi: 10.1093/glycob/cwt049. Epub 2013 Jun 27.


MicroRNA-7 inhibits tumor metastasis and reverses epithelial-mesenchymal transition through AKT/ERK1/2 inactivation by targeting EGFR in epithelial ovarian cancer.

Zhou X, Hu Y, Dai L, Wang Y, Zhou J, Wang W, Di W, Qiu L.

PLoS One. 2014 May 9;9(5):e96718. doi: 10.1371/journal.pone.0096718. eCollection 2014.


Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1.

Demers MJ, Thibodeau S, Noël D, Fujita N, Tsuruo T, Gauthier R, Arguin M, Vachon PH.

J Cell Biochem. 2009 Jul 1;107(4):639-54. doi: 10.1002/jcb.22131.

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