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Items: 1 to 20 of 120

1.

5-aza-2'-deoxycytidine-mediated c-myc Down-regulation triggers telomere-dependent senescence by regulating human telomerase reverse transcriptase in chronic myeloid leukemia.

Grandjenette C, Schnekenburger M, Karius T, Ghelfi J, Gaigneaux A, Henry E, Dicato M, Diederich M.

Neoplasia. 2014 Jun;16(6):511-28. doi: 10.1016/j.neo.2014.05.009. Epub 2014 Jun 24.

3.

Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death.

Pettigrew KA, Armstrong RN, Colyer HA, Zhang SD, Rea IM, Jones RE, Baird DM, Mills KI.

Genes Chromosomes Cancer. 2012 Aug;51(8):768-80. doi: 10.1002/gcc.21962. Epub 2012 Apr 19.

PMID:
22517724
4.

hTERT, the catalytic component of telomerase, is downregulated in the haematopoietic stem cells of patients with chronic myeloid leukaemia.

Campbell LJ, Fidler C, Eagleton H, Peniket A, Kusec R, Gal S, Littlewood TJ, Wainscoat JS, Boultwood J.

Leukemia. 2006 Apr;20(4):671-9.

PMID:
16498395
5.

Butein suppresses c-Myc-dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells.

Moon DO, Kim MO, Lee JD, Choi YH, Kim GY.

Cancer Lett. 2009 Dec 28;286(2):172-9. doi: 10.1016/j.canlet.2009.05.028. Epub 2009 Jun 27.

PMID:
19560862
6.

The antiretroviral agent saquinavir enhances hTERT expression and telomerase activity in human T leukaemia cells in vitro.

Adamo R, Comandini A, Aquino A, Bonmassar L, Guglielmi L, Bonmassar E, Franzese O.

J Exp Clin Cancer Res. 2013 Jun 8;32:38. doi: 10.1186/1756-9966-32-38.

7.

MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells.

Ponnala S, Chetty C, Veeravalli KK, Dinh DH, Klopfenstein JD, Rao JS.

Cell Signal. 2011 Dec;23(12):2065-75. doi: 10.1016/j.cellsig.2011.08.001. Epub 2011 Aug 9. Erratum in: Cell Signal. 2013 Aug;25(8):1729.

8.

Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase.

Zhang D, Sun X, Liu J, Xie X, Cui W, Zhu Y.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):71-8. doi: 10.1161/ATVBAHA.114.303899. Epub 2014 Oct 30.

9.

TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.

Lafferty-Whyte K, Bilsland A, Hoare SF, Burns S, Zaffaroni N, Cairney CJ, Keith WN.

Neoplasia. 2010 May;12(5):405-14.

10.

Sustained exposure to the DNA demethylating agent, 2'-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy.

Schnekenburger M, Grandjenette C, Ghelfi J, Karius T, Foliguet B, Dicato M, Diederich M.

Biochem Pharmacol. 2011 Feb 1;81(3):364-78. doi: 10.1016/j.bcp.2010.10.013. Epub 2010 Oct 31.

PMID:
21044612
11.
12.

Anti-tumor effect of 5-aza-2'-deoxycytidine by inhibiting telomerase activity in hepatocellular carcinoma cells.

Tao SF, Zhang CS, Guo XL, Xu Y, Zhang SS, Song JR, Li R, Wu MC, Wei LX.

World J Gastroenterol. 2012 May 21;18(19):2334-43. doi: 10.3748/wjg.v18.i19.2334.

13.
14.

JunB gene expression is inactivated by methylation in chronic myeloid leukemia.

Yang MY, Liu TC, Chang JG, Lin PM, Lin SF.

Blood. 2003 Apr 15;101(8):3205-11. Epub 2002 Dec 27.

15.

Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer.

Yoon JH, Seo HS, Choi WS, Kim O, Nam SW, Lee JY, Park WS.

Oncotarget. 2014 Nov 30;5(22):11695-708.

16.

Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells.

Venturini L, Battmer K, Castoldi M, Schultheis B, Hochhaus A, Muckenthaler MU, Ganser A, Eder M, Scherr M.

Blood. 2007 May 15;109(10):4399-405. Epub 2007 Feb 6.

17.

Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia.

San José-Eneriz E, Agirre X, Jiménez-Velasco A, Cordeu L, Martín V, Arqueros V, Gárate L, Fresquet V, Cervantes F, Martínez-Climent JA, Heiniger A, Torres A, Prósper F, Roman-Gomez J.

Eur J Cancer. 2009 Jul;45(10):1877-89. doi: 10.1016/j.ejca.2009.04.005. Epub 2009 May 4.

PMID:
19403302
18.

siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells.

Hao H, Nancai Y, Lei F, Xiong W, Wen S, Guofu H, Yanxia W, Hanju H, Qian L, Hong X.

J Exp Clin Cancer Res. 2008 Aug 12;27:27. doi: 10.1186/1756-9966-27-27. Retraction in: J Exp Clin Cancer Res. 2009;28:101.

19.

Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity.

Ducrest AL, Amacker M, Mathieu YD, Cuthbert AP, Trott DA, Newbold RF, Nabholz M, Lingner J.

Cancer Res. 2001 Oct 15;61(20):7594-602.

20.
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