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Results: 1 to 20 of 101

1.

Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists.

McCoull W, Barton P, Brown AJ, Bowker SS, Cameron J, Clarke DS, Davies RD, Dossetter AG, Ertan A, Fenwick M, Green C, Holmes JL, Martin N, Masters D, Moore JE, Newcombe NJ, Newton C, Pointon H, Robb GR, Sheldon C, Stokes S, Morgan D.

J Med Chem. 2014 Jul 24;57(14):6128-40. doi: 10.1021/jm500610n. Epub 2014 Jul 8.

PMID:
24967667
[PubMed - in process]
2.

Ghrelin control of GH secretion and feeding behaviour: the role of the GHS-R1a receptor studied in vivo and in vitro using novel non-peptide ligands.

Bresciani E, Tamiazzo L, Torsello A, Bulgarelli I, Rapetti D, Caporali S, Perrissoud D, Moulin A, Fehrentz JA, Martinez J, Locatelli V.

Eat Weight Disord. 2008 Sep;13(3):e67-74.

PMID:
19011367
[PubMed - indexed for MEDLINE]
3.

Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.

Schellekens H, van Oeffelen WE, Dinan TG, Cryan JF.

J Biol Chem. 2013 Jan 4;288(1):181-91. doi: 10.1074/jbc.M112.382473. Epub 2012 Nov 16.

PMID:
23161547
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a.

Casanueva FF, Camiña JP, Carreira MC, Pazos Y, Varga JL, Schally AV.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20452-7. doi: 10.1073/pnas.0811680106. Epub 2008 Dec 16.

PMID:
19088192
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging.

Smith RG, Sun Y, Jiang H, Albarran-Zeckler R, Timchenko N.

Ann N Y Acad Sci. 2007 Nov;1119:147-64. Review.

PMID:
18056963
[PubMed - indexed for MEDLINE]
6.

Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats.

Salomé N, Haage D, Perrissoud D, Moulin A, Demange L, Egecioglu E, Fehrentz JA, Martinez J, Dickson SL.

Eur J Pharmacol. 2009 Jun 10;612(1-3):167-73. doi: 10.1016/j.ejphar.2009.03.066. Epub 2009 Apr 5.

PMID:
19356720
[PubMed - indexed for MEDLINE]
7.

Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss.

Esler WP, Rudolph J, Claus TH, Tang W, Barucci N, Brown SE, Bullock W, Daly M, Decarr L, Li Y, Milardo L, Molstad D, Zhu J, Gardell SJ, Livingston JN, Sweet LJ.

Endocrinology. 2007 Nov;148(11):5175-85. Epub 2007 Jul 26.

PMID:
17656463
[PubMed - indexed for MEDLINE]
8.

Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction.

Yakabi K, Kurosawa S, Tamai M, Yuzurihara M, Nahata M, Ohno S, Ro S, Kato S, Aoyama T, Sakurada T, Takabayashi H, Hattori T.

Regul Pept. 2010 Apr 9;161(1-3):97-105. doi: 10.1016/j.regpep.2010.02.003. Epub 2010 Feb 19.

PMID:
20171995
[PubMed - indexed for MEDLINE]
9.

GHS-R1a constitutive activity and its physiological relevance.

Mear Y, Enjalbert A, Thirion S.

Front Neurosci. 2013 May 29;7:87. doi: 10.3389/fnins.2013.00087. eCollection 2013.

PMID:
23754971
[PubMed]
Free PMC Article
10.

Food restriction, ghrelin, its antagonist and obestatin control expression of ghrelin and its receptor in chicken hypothalamus and ovary.

Sirotkin AV, Pavlova S, Tena-Sempere M, Grossmann R, Jiménez MR, Rodriguez JM, Valenzuela F.

Comp Biochem Physiol A Mol Integr Physiol. 2013 Jan;164(1):141-53. doi: 10.1016/j.cbpa.2012.07.010. Epub 2012 Aug 1.

PMID:
22877785
[PubMed - indexed for MEDLINE]
11.

Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward.

Schellekens H, Dinan TG, Cryan JF.

Front Neurosci. 2013 Aug 30;7:148. doi: 10.3389/fnins.2013.00148. Review.

PMID:
24009547
[PubMed]
Free PMC Article
12.

Semagacestat, a γ-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor.

Schellekens H, McNamara O, Dinan TG, McCarthy JV, McGlacken GP, Cryan JF.

J Pharm Pharmacol. 2013 Apr;65(4):528-38. doi: 10.1111/jphp.12010. Epub 2012 Nov 27.

PMID:
23488781
[PubMed - indexed for MEDLINE]
13.

Adenosine does not bind to the growth hormone secretagogue receptor type-1a (GHS-R1a).

Carreira MC, Camiña JP, Díaz-Rodríguez E, Alvear-Perez R, Llorens-Cortes C, Casanueva FF.

J Endocrinol. 2006 Oct;191(1):147-57.

PMID:
17065398
[PubMed - indexed for MEDLINE]
Free Article
14.

High constitutive activity is an intrinsic feature of ghrelin receptor protein: a study with a functional monomeric GHS-R1a receptor reconstituted in lipid discs.

Damian M, Marie J, Leyris JP, Fehrentz JA, Verdié P, Martinez J, Banères JL, Mary S.

J Biol Chem. 2012 Feb 3;287(6):3630-41. doi: 10.1074/jbc.M111.288324. Epub 2011 Nov 23.

PMID:
22117076
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Heterogeneity of ghrelin/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin/GHS receptors.

Muccioli G, Baragli A, Granata R, Papotti M, Ghigo E.

Neuroendocrinology. 2007;86(3):147-64. Epub 2007 Jul 2. Review.

PMID:
17622734
[PubMed - indexed for MEDLINE]
16.

Actions of Agonists and Antagonists of the ghrelin/GHS-R Pathway on GH Secretion, Appetite, and cFos Activity.

Hassouna R, Labarthe A, Zizzari P, Videau C, Culler M, Epelbaum J, Tolle V.

Front Endocrinol (Lausanne). 2013 Mar 18;4:25. doi: 10.3389/fendo.2013.00025. eCollection 2013.

PMID:
23515849
[PubMed]
Free PMC Article
17.

Involvement of tryptophan W276 and of two surrounding amino acid residues in the high constitutive activity of the ghrelin receptor GHS-R1a.

Gozé C, Bergé G, M'Kadmi C, Floquet N, Gagne D, Galleyrand JC, Fehrentz JA, Martinez J.

Eur J Pharmacol. 2010 Sep 25;643(2-3):153-61. doi: 10.1016/j.ejphar.2010.06.018. Epub 2010 Jun 30.

PMID:
20599926
[PubMed - indexed for MEDLINE]
18.

Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig.

Kitazawa T, Nakamura T, Saeki A, Teraoka H, Hiraga T, Kaiya H.

Peptides. 2011 Sep;32(9):1876-86. doi: 10.1016/j.peptides.2011.07.026. Epub 2011 Aug 6.

PMID:
21843569
[PubMed - indexed for MEDLINE]
19.

Two functional growth hormone secretagogue receptor (ghrelin receptor) type 1a and 2a in goldfish, Carassius auratus.

Kaiya H, Miura T, Matsuda K, Miyazato M, Kangawa K.

Mol Cell Endocrinol. 2010 Oct 7;327(1-2):25-39. doi: 10.1016/j.mce.2010.06.004. Epub 2010 Jun 15.

PMID:
20558240
[PubMed - indexed for MEDLINE]
20.

Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release.

Park S, Jiang H, Zhang H, Smith RG.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):19003-8. doi: 10.1073/pnas.1209590109. Epub 2012 Oct 29.

PMID:
23112170
[PubMed - indexed for MEDLINE]
Free PMC Article

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