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Results: 1 to 20 of 101

1.

β-Amyrin biosynthesis: the critical role of steric volume at C-19 of 2,3-oxidosqualene for its correct folding to generate the pentacyclic scaffold.

Hoshino T, Yamaguchi Y, Takahashi K, Ito R.

Org Lett. 2014 Jul 3;16(13):3548-51. doi: 10.1021/ol501498q. Epub 2014 Jun 24.

PMID:
24960408
[PubMed - in process]
2.

β-Amyrin synthase from Euphorbia tirucalli. Steric bulk, not the π-electrons of Phe, at position 474 has a key role in affording the correct folding of the substrate to complete the normal polycyclization cascade.

Ito R, Masukawa Y, Nakada C, Amari K, Nakano C, Hoshino T.

Org Biomol Chem. 2014 Jun 21;12(23):3836-46. doi: 10.1039/c4ob00064a.

PMID:
24695673
[PubMed - in process]
3.

Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases.

Ito R, Masukawa Y, Hoshino T.

FEBS J. 2013 Mar;280(5):1267-80. doi: 10.1111/febs.12119. Epub 2013 Feb 13.

PMID:
23294602
[PubMed - indexed for MEDLINE]
4.

Lanosterol biosynthesis: the critical role of the methyl-29 group of 2,3-oxidosqualene for the correct folding of this substrate and for the construction of the five-membered D ring.

Hoshino T, Chiba A, Abe N.

Chemistry. 2012 Oct 8;18(41):13108-16. doi: 10.1002/chem.201201779. Epub 2012 Aug 30.

PMID:
22933236
[PubMed - indexed for MEDLINE]
5.

Mechanism and stereochemistry of enzymatic cyclization of 24,30-Bisnor-2,3-oxidosqualene by recombinant beta-amyrin synthase.

Abe I, Sakano Y, Sodeyama M, Tanaka H, Noguchi H, Shibuya M, Ebizuka Y.

J Am Chem Soc. 2004 Jun 9;126(22):6880-1.

PMID:
15174853
[PubMed - indexed for MEDLINE]
7.

Effect of cation-π interactions and steric bulk on the catalytic action of oxidosqualene cyclase: a case study of Phe728 of β-amyrin synthase from Euphorbia tirucalli L.

Ito R, Hashimoto I, Masukawa Y, Hoshino T.

Chemistry. 2013 Dec 9;19(50):17150-8. doi: 10.1002/chem.201301917. Epub 2013 Nov 6.

PMID:
24203491
[PubMed - indexed for MEDLINE]
8.

Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants.

Kushiro T, Shibuya M, Ebizuka Y.

Eur J Biochem. 1998 Aug 15;256(1):238-44.

PMID:
9746369
[PubMed - indexed for MEDLINE]
Free Article
9.

Methyl jasmonate-elicited transcriptional responses and pentacyclic triterpene biosynthesis in sweet basil.

Misra RC, Maiti P, Chanotiya CS, Shanker K, Ghosh S.

Plant Physiol. 2014 Feb;164(2):1028-44. doi: 10.1104/pp.113.232884. Epub 2013 Dec 23.

PMID:
24367017
[PubMed - in process]
10.

Isolation and characterization of an oxidosqualene cyclase gene encoding a β-amyrin synthase involved in Polygala tenuifolia Willd. saponin biosynthesis.

Jin ML, Lee DY, Um Y, Lee JH, Park CG, Jetter R, Kim OT.

Plant Cell Rep. 2014 Mar;33(3):511-9. doi: 10.1007/s00299-013-1554-7. Epub 2014 Jan 14.

PMID:
24420413
[PubMed - in process]
11.

An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica.

Brendolise C, Yauk YK, Eberhard ED, Wang M, Chagne D, Andre C, Greenwood DR, Beuning LL.

FEBS J. 2011 Jul;278(14):2485-99. doi: 10.1111/j.1742-4658.2011.08175.x. Epub 2011 Jun 24.

PMID:
21575133
[PubMed - indexed for MEDLINE]
12.

Inhibition of 2,3-oxidosqualene cyclases.

Taton M, Benveniste P, Rahier A, Johnson WS, Liu HT, Sudhakar AR.

Biochemistry. 1992 Sep 1;31(34):7892-8.

PMID:
1510977
[PubMed - indexed for MEDLINE]
13.

Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin.

Seki H, Ohyama K, Sawai S, Mizutani M, Ohnishi T, Sudo H, Akashi T, Aoki T, Saito K, Muranaka T.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14204-9. doi: 10.1073/pnas.0803876105. Epub 2008 Sep 8.

PMID:
18779566
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol.

Segura MJ, Meyer MM, Matsuda SP.

Org Lett. 2000 Jul 27;2(15):2257-9.

PMID:
10930257
[PubMed - indexed for MEDLINE]
15.

Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra.

Hayashi H, Huang P, Takada S, Obinata M, Inoue K, Shibuya M, Ebizuka Y.

Biol Pharm Bull. 2004 Jul;27(7):1086-92.

PMID:
15256745
[PubMed - indexed for MEDLINE]
Free Article
16.

Arabidopsis camelliol C synthase evolved from enzymes that make pentacycles.

Kolesnikova MD, Wilson WK, Lynch DA, Obermeyer AC, Matsuda SP.

Org Lett. 2007 Dec 6;9(25):5223-6. Epub 2007 Nov 7.

PMID:
17985917
[PubMed - indexed for MEDLINE]
17.

Reviewing the polyolefin cyclization reaction of the c(35) polyprene catalyzed by squalene-hopene cyclase.

Hoshino T, Kumai Y, Sato T.

Chemistry. 2009;15(9):2091-100. doi: 10.1002/chem.200802142. Erratum in: Chemistry. 2009 Jul 27;15(30):7263.

PMID:
19142932
[PubMed - indexed for MEDLINE]
18.

Nonenzymic polycyclization of analogues of oxidosqualene with a preformed C-ring.

Winne JM, De Clercq PJ, Milanesio M, Pattison P, Viterbo D.

Org Biomol Chem. 2008 Jun 7;6(11):1918-25. doi: 10.1039/b801670d. Epub 2008 Apr 8.

PMID:
18480904
[PubMed - indexed for MEDLINE]
19.

CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis.

Fukushima EO, Seki H, Ohyama K, Ono E, Umemoto N, Mizutani M, Saito K, Muranaka T.

Plant Cell Physiol. 2011 Dec;52(12):2050-61. doi: 10.1093/pcp/pcr146. Epub 2011 Oct 28.

PMID:
22039103
[PubMed - indexed for MEDLINE]
20.

Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus.

Huang L, Li J, Ye H, Li C, Wang H, Liu B, Zhang Y.

Planta. 2012 Nov;236(5):1571-81. doi: 10.1007/s00425-012-1712-0. Epub 2012 Jul 27. Erratum in: Planta. 2012 Nov;236(5):1583.

PMID:
22837051
[PubMed - indexed for MEDLINE]

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