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Results: 1 to 20 of 101

1.

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding.

Canault M, Ghalloussi D, Grosdidier C, Guinier M, Perret C, Chelghoum N, Germain M, Raslova H, Peiretti F, Morange PE, Saut N, Pillois X, Nurden AT, Cambien F, Pierres A, van den Berg TK, Kuijpers TW, Alessi MC, Tregouet DA.

J Exp Med. 2014 Jun 30;211(7):1349-62. doi: 10.1084/jem.20130477. Epub 2014 Jun 23.

PMID:
24958846
[PubMed - indexed for MEDLINE]
2.

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.

Cifuni SM, Wagner DD, Bergmeier W.

Blood. 2008 Sep 1;112(5):1696-703. doi: 10.1182/blood-2008-02-139733. Epub 2008 Jun 10.

PMID:
18544684
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.

Subramanian H, Zahedi RP, Sickmann A, Walter U, Gambaryan S.

J Thromb Haemost. 2013 Aug;11(8):1574-82. doi: 10.1111/jth.12271.

PMID:
23611601
[PubMed - indexed for MEDLINE]
4.

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.

Stefanini L, Roden RC, Bergmeier W.

Blood. 2009 Sep 17;114(12):2506-14. doi: 10.1182/blood-2009-04-218768. Epub 2009 Jul 23.

PMID:
19628710
[PubMed - indexed for MEDLINE]
Free Article
5.

The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.

Stolla M, Stefanini L, Roden RC, Chavez M, Hirsch J, Greene T, Ouellette TD, Maloney SF, Diamond SL, Poncz M, Woulfe DS, Bergmeier W.

Blood. 2011 Jan 20;117(3):1005-13. doi: 10.1182/blood-2010-07-297713. Epub 2010 Oct 22.

PMID:
20971951
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Calcium-diacylglycerol guanine nucleotide exchange factor I gene mutations associated with loss of function in canine platelets.

Boudreaux MK, Catalfamo JL, Klok M.

Transl Res. 2007 Aug;150(2):81-92. Epub 2007 May 25.

PMID:
17656327
[PubMed - indexed for MEDLINE]
7.

Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.

Bergmeier W, Goerge T, Wang HW, Crittenden JR, Baldwin AC, Cifuni SM, Housman DE, Graybiel AM, Wagner DD.

J Clin Invest. 2007 Jun;117(6):1699-707. Epub 2007 May 10.

PMID:
17492052
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca(2+)-dependent activation of platelet Rap1b GTPase.

Guidetti GF, Manganaro D, Consonni A, Canobbio I, Balduini C, Torti M.

Biochem J. 2013 Jul 1;453(1):115-23. doi: 10.1042/BJ20130131.

PMID:
23600630
[PubMed - indexed for MEDLINE]
Free Article
9.

Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor.

Clyde-Smith J, Silins G, Gartside M, Grimmond S, Etheridge M, Apolloni A, Hayward N, Hancock JF.

J Biol Chem. 2000 Oct 13;275(41):32260-7.

PMID:
10918068
[PubMed - indexed for MEDLINE]
Free Article
10.

Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.

Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, Nakano T, Leavitt AD, Shattil SJ.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12819-24. Epub 2002 Sep 18.

PMID:
12239348
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

CalDAG-GEFI and platelet activation.

Stefanini L, Bergmeier W.

Platelets. 2010;21(4):239-43. doi: 10.3109/09537101003639931. Review.

PMID:
20218908
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Identification of a severe bleeding disorder in humans caused by a mutation in CalDAG-GEFI.

Muller WA.

J Exp Med. 2014 Jun 30;211(7):1271. doi: 10.1084/jem.2117insight1. No abstract available.

PMID:
24980744
[PubMed - indexed for MEDLINE]
13.

Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis.

Ahmad F, Boulaftali Y, Greene TK, Ouellette TD, Poncz M, Feske S, Bergmeier W.

J Thromb Haemost. 2011 Oct;9(10):2077-86. doi: 10.1111/j.1538-7836.2011.04474.x.

PMID:
21848641
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation.

Crittenden JR, Bergmeier W, Zhang Y, Piffath CL, Liang Y, Wagner DD, Housman DE, Graybiel AM.

Nat Med. 2004 Sep;10(9):982-6. Epub 2004 Aug 29. Erratum in: Nat Med. 2004 Oct;10(10):1139.

PMID:
15334074
[PubMed - indexed for MEDLINE]
15.

CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.

Stolla M, Stefanini L, André P, Ouellette TD, Reilly MP, McKenzie SE, Bergmeier W.

Blood. 2011 Jul 28;118(4):1113-20. doi: 10.1182/blood-2011-03-342352. Epub 2011 Jun 7.

PMID:
21652673
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2.

Guo FF, Kumahara E, Saffen D.

J Biol Chem. 2001 Jul 6;276(27):25568-81. Epub 2001 Apr 5.

PMID:
11292831
[PubMed - indexed for MEDLINE]
Free Article
17.

A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets.

Pasvolsky R, Feigelson SW, Kilic SS, Simon AJ, Tal-Lapidot G, Grabovsky V, Crittenden JR, Amariglio N, Safran M, Graybiel AM, Rechavi G, Ben-Dor S, Etzioni A, Alon R.

J Exp Med. 2007 Jul 9;204(7):1571-82. Epub 2007 Jun 18.

PMID:
17576779
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Identification of CalDAG-GEFI as an intracellular target for the vicinal dithiol binding agent phenylarsine oxide in human platelets.

Kuo CY, Wang HC, Kung PH, Lu CY, Liao CY, Wu MT, Wu CC.

Thromb Haemost. 2014 May 5;111(5):892-901. doi: 10.1160/TH13-07-0629. Epub 2013 Dec 19.

PMID:
24352565
[PubMed - in process]
19.

Novel integrin-dependent platelet malfunction in siblings with leukocyte adhesion deficiency-III (LAD-III) caused by a point mutation in FERMT3.

Jurk K, Schulz AS, Kehrel BE, Räpple D, Schulze H, Möbest D, Friedrich WW, Omran H, Deak E, Henschler R, Scheele JS, Zieger B.

Thromb Haemost. 2010 May;103(5):1053-64. doi: 10.1160/TH09-10-0689. Epub 2010 Mar 9.

PMID:
20216991
[PubMed - indexed for MEDLINE]
20.

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling.

Stadtmann A, Brinkhaus L, Mueller H, Rossaint J, Bolomini-Vittori M, Bergmeier W, Van Aken H, Wagner DD, Laudanna C, Ley K, Zarbock A.

Eur J Immunol. 2011 Jul;41(7):2074-85. doi: 10.1002/eji.201041196. Epub 2011 Jun 7.

PMID:
21480213
[PubMed - indexed for MEDLINE]
Free PMC Article

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