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Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women.

Parkington HC, Stevenson J, Tonta MA, Paul J, Butler T, Maiti K, Chan EC, Sheehan PM, Brennecke SP, Coleman HA, Smith R.

Nat Commun. 2014 Jun 17;5:4108. doi: 10.1038/ncomms5108.


Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel.

Kang J, Chen XL, Wang H, Ji J, Cheng H, Incardona J, Reynolds W, Viviani F, Tabart M, Rampe D.

Mol Pharmacol. 2005 Mar;67(3):827-36. Epub 2004 Nov 17.


Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking.

Wang L, Wible BA, Wan X, Ficker E.

J Pharmacol Exp Ther. 2007 Feb;320(2):525-34. Epub 2006 Nov 9.


RNA interference reveals that endogenous Xenopus MinK-related peptides govern mammalian K+ channel function in oocyte expression studies.

Anantharam A, Lewis A, Panaghie G, Gordon E, McCrossan ZA, Lerner DJ, Abbott GW.

J Biol Chem. 2003 Apr 4;278(14):11739-45. Epub 2003 Jan 15.


2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels.

Gordon E, Lozinskaya IM, Lin Z, Semus SF, Blaney FE, Willette RN, Xu X.

Mol Pharmacol. 2008 Mar;73(3):639-51. Epub 2007 Nov 27.


Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator.

Zeng H, Lozinskaya IM, Lin Z, Willette RN, Brooks DP, Xu X.

J Pharmacol Exp Ther. 2006 Nov;319(2):957-62. Epub 2006 Aug 23.


HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs.

Bai YL, Liu HB, Sun B, Zhang Y, Li Q, Hu CW, Zhu JX, Gong DM, Teng X, Zhang Q, Yang BF, Dong DL.

J Mol Cell Cardiol. 2011 Nov;51(5):876-80. doi: 10.1016/j.yjmcc.2011.07.017. Epub 2011 Jul 28.


Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization.

Schwoerer AP, Blütner C, Brandt S, Binder S, Siebrands CC, Ehmke H, Friederich P.

Anesthesiology. 2007 May;106(5):967-76.


Impairment of HERG K(+) channel function by tumor necrosis factor-alpha: role of reactive oxygen species as a mediator.

Wang J, Wang H, Zhang Y, Gao H, Nattel S, Wang Z.

J Biol Chem. 2004 Apr 2;279(14):13289-92. Epub 2004 Feb 17.


Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration.

Hong HK, Lee BH, Park MH, Lee SH, Chu D, Kim WJ, Choe H, Hee Choi B, Jo SH.

Eur J Pharmacol. 2013 Feb 28;702(1-3):165-73. doi: 10.1016/j.ejphar.2013.01.039. Epub 2013 Feb 6.


Novel effects of extracts from poisonous mushrooms on expression and function of the human ether-a-go-go-related gene channel.

Li P, Tanaka S, Ichiyanagi T, Ninomiya H, Ting Y, Utami SB, Aimi T, Shirayoshi Y, Miake J, Hisatome I.

Biol Pharm Bull. 2011;34(9):1474-80.


Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574).

Gerlach AC, Stoehr SJ, Castle NA.

Mol Pharmacol. 2010 Jan;77(1):58-68. doi: 10.1124/mol.109.059543. Epub 2009 Oct 5.


Phospholipid metabolite 1-palmitoyl-lysophosphatidylcholine enhances human ether-a-go-go-related gene (HERG) K(+) channel function.

Wang J, Wang H, Han H, Zhang Y, Yang B, Nattel S, Wang Z.

Circulation. 2001 Nov 27;104(22):2645-8.


Both EGFR kinase and Src-related tyrosine kinases regulate human ether-à-go-go-related gene potassium channels.

Zhang DY, Wang Y, Lau CP, Tse HF, Li GR.

Cell Signal. 2008 Oct;20(10):1815-21. doi: 10.1016/j.cellsig.2008.06.006. Epub 2008 Jun 19.


The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels.

Tang Q, Li ZQ, Li W, Guo J, Sun HY, Zhang XH, Lau CP, Tse HF, Zhang S, Li GR.

Br J Pharmacol. 2008 Oct;155(3):365-73. doi: 10.1038/bjp.2008.261. Epub 2008 Jun 23.


Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.

Davie C, Pierre-Valentin J, Pollard C, Standen N, Mitcheson J, Alexander P, Thong B.

J Cardiovasc Electrophysiol. 2004 Nov;15(11):1302-9.


Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity.

Yunomae K, Ichisaki S, Matsuo J, Nagayama S, Fukuzaki K, Nagata R, Kito G.

J Appl Toxicol. 2007 Jan-Feb;27(1):78-85.


A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-à-go-go-related gene channel.

Kinoshita K, Yamaguchi Y, Nishide K, Kimoto K, Nonobe Y, Fujita A, Asano K, Tabata T, Mori H, Inoue H, Hata Y, Fukurotani K, Nishida N.

J Cardiovasc Electrophysiol. 2012 Nov;23(11):1246-53. doi: 10.1111/j.1540-8167.2012.02383.x. Epub 2012 Jul 5.

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