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Items: 1 to 20 of 125


Oncostatin M overexpression induces matrix deposition, STAT3 activation, and SMAD1 Dysregulation in lungs of fibrosis-resistant BALB/c mice.

Wong S, Botelho FM, Rodrigues RM, Richards CD.

Lab Invest. 2014 Sep;94(9):1003-16. doi: 10.1038/labinvest.2014.81. Epub 2014 Jun 16.


A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis is STAT6 independent.

Fritz DK, Kerr C, Fattouh R, Llop-Guevara A, Khan WI, Jordana M, Richards CD.

J Immunol. 2011 Jan 15;186(2):1107-18. doi: 10.4049/jimmunol.0903476. Epub 2010 Dec 15.


Mechanisms of oncostatin M-induced pulmonary inflammation and fibrosis.

Mozaffarian A, Brewer AW, Trueblood ES, Luzina IG, Todd NW, Atamas SP, Arnett HA.

J Immunol. 2008 Nov 15;181(10):7243-53.


Oncostatin M regulates eotaxin expression in fibroblasts and eosinophilic inflammation in C57BL/6 mice.

Langdon C, Kerr C, Tong L, Richards CD.

J Immunol. 2003 Jan 1;170(1):548-55.


Oncostatin M modulates fibroblast function via signal transducers and activators of transcription proteins-3.

Nagahama KY, Togo S, Holz O, Magnussen H, Liu X, Seyama K, Takahashi K, Rennard SI.

Am J Respir Cell Mol Biol. 2013 Oct;49(4):582-91. doi: 10.1165/rcmb.2012-0460OC.


Modulation of extracellular matrix using adenovirus vectors.

Richards CD, Kerr C, Tong L, Langdon C.

Biochem Soc Trans. 2002 Apr;30(2):107-11.


Oncostatin M inhibits TGF-β1-induced CTGF expression via STAT3 in human proximal tubular cells.

Sarközi R, Flucher K, Haller VM, Pirklbauer M, Mayer G, Schramek H.

Biochem Biophys Res Commun. 2012 Aug 10;424(4):801-6. doi: 10.1016/j.bbrc.2012.07.042. Epub 2012 Jul 16.


Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.

Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards CD.

Respir Res. 2015 Feb 7;16:14. doi: 10.1186/s12931-014-0164-4.


Novel function of Oncostatin M as a potent tumour-promoting agent in lung.

Lauber S, Wong S, Cutz JC, Tanaka M, Barra N, Lhoták S, Ashkar A, Richards CD.

Int J Cancer. 2015 Feb 15;136(4):831-43. doi: 10.1002/ijc.29055. Epub 2014 Jul 7.


Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis.

Myllärniemi M, Lindholm P, Ryynänen MJ, Kliment CR, Salmenkivi K, Keski-Oja J, Kinnula VL, Oury TD, Koli K.

Am J Respir Crit Care Med. 2008 Feb 1;177(3):321-9. Epub 2007 Nov 1.


Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition.

Guo L, Chen C, Shi M, Wang F, Chen X, Diao D, Hu M, Yu M, Qian L, Guo N.

Oncogene. 2013 Nov 7;32(45):5272-82. doi: 10.1038/onc.2012.573. Epub 2013 Jan 14.


Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL-6 in OSM-driven pulmonary inflammation.

Botelho FM, Rangel-Moreno J, Fritz D, Randall TD, Xing Z, Richards CD.

J Immunol. 2013 Aug 1;191(3):1453-64. doi: 10.4049/jimmunol.1203318. Epub 2013 Jun 24.


Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains.

Kolb M, Bonniaud P, Galt T, Sime PJ, Kelly MM, Margetts PJ, Gauldie J.

Am J Respir Cell Mol Biol. 2002 Aug;27(2):141-50.


Oncostatin M is a novel inhibitor of TGF-β1-induced matricellular protein expression.

Sarközi R, Hauser C, Noppert SJ, Kronbichler A, Pirklbauer M, Haller VM, Grillari J, Grillari-Voglauer R, Mayer G, Schramek H.

Am J Physiol Renal Physiol. 2011 Nov;301(5):F1014-25. doi: 10.1152/ajprenal.00123.2011. Epub 2011 Aug 3.


Oncostatin M binds to extracellular matrix in a bioactive conformation: implications for inflammation and metastasis.

Ryan RE, Martin B, Mellor L, Jacob RB, Tawara K, McDougal OM, Oxford JT, Jorcyk CL.

Cytokine. 2015 Mar;72(1):71-85. doi: 10.1016/j.cyto.2014.11.007. Epub 2015 Jan 23.


IL-6 receptor-mediated lung Th2 cytokine networking in silica-induced pulmonary fibrosis.

Tripathi SS, Mishra V, Shukla M, Verma M, Chaudhury BP, Kumar P, Chhabra JK, Pandey HP, Paul B.

Arch Toxicol. 2010 Dec;84(12):947-55. doi: 10.1007/s00204-010-0559-z. Epub 2010 May 20.


Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis.

Bonniaud P, Kolb M, Galt T, Robertson J, Robbins C, Stampfli M, Lavery C, Margetts PJ, Roberts AB, Gauldie J.

J Immunol. 2004 Aug 1;173(3):2099-108.


Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines.

Fossey SL, Bear MD, Kisseberth WC, Pennell M, London CA.

BMC Cancer. 2011 Apr 11;11:125. doi: 10.1186/1471-2407-11-125.


Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells.

Fukuda S, Abematsu M, Mori H, Yanagisawa M, Kagawa T, Nakashima K, Yoshimura A, Taga T.

Mol Cell Biol. 2007 Jul;27(13):4931-7. Epub 2007 Apr 23.


Oncostatin M induces IL-33 expression in liver endothelial cells in mice and expands ST2+CD4+ lymphocytes.

Arshad MI, Guihard P, Danger Y, Noel G, Le Seyec J, Boutet MA, Richards CD, L'Helgoualc'h A, Genet V, Lucas-Clerc C, Gascan H, Blanchard F, Piquet-Pellorce C, Samson M.

Am J Physiol Gastrointest Liver Physiol. 2015 Oct 1;309(7):G542-53. doi: 10.1152/ajpgi.00398.2014. Epub 2015 Aug 6.

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