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Items: 1 to 20 of 104

1.

Folded small molecule manipulation of islet amyloid polypeptide.

Kumar S, Brown MA, Nath A, Miranker AD.

Chem Biol. 2014 Jun 19;21(6):775-81. doi: 10.1016/j.chembiol.2014.05.007. Epub 2014 Jun 12.

2.

Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics.

Kumar S, Schlamadinger DE, Brown MA, Dunn JM, Mercado B, Hebda JA, Saraogi I, Rhoades E, Hamilton AD, Miranker AD.

Chem Biol. 2015 Mar 19;22(3):369-78. doi: 10.1016/j.chembiol.2015.01.006. Epub 2015 Mar 5.

3.

Peptide amyloid surface display.

Rubio MA, Schlamadinger DE, White EM, Miranker AD.

Biochemistry. 2015 Feb 3;54(4):987-93. doi: 10.1021/bi5011442. Epub 2015 Jan 20.

4.

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide.

Kumar S, Miranker AD.

Chem Commun (Camb). 2013 May 25;49(42):4749-51. doi: 10.1039/c3cc41452c.

5.

Small molecule screening in context: lipid-catalyzed amyloid formation.

Hebda JA, Magzoub M, Miranker AD.

Protein Sci. 2014 Oct;23(10):1341-8. doi: 10.1002/pro.2518. Epub 2014 Jul 28.

6.

Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity.

Cao P, Marek P, Noor H, Patsalo V, Tu LH, Wang H, Abedini A, Raleigh DP.

FEBS Lett. 2013 Apr 17;587(8):1106-18. doi: 10.1016/j.febslet.2013.01.046. Epub 2013 Feb 1. Review.

7.

Binding of islet amyloid polypeptide to supported lipid bilayers and amyloid aggregation at the membranes.

Sasahara K, Morigaki K, Okazaki T, Hamada D.

Biochemistry. 2012 Sep 4;51(35):6908-19. doi: 10.1021/bi300542g. Epub 2012 Aug 23.

PMID:
22876830
8.

Low pH acts as inhibitor of membrane damage induced by human islet amyloid polypeptide.

Khemtémourian L, Doménech E, Doux JP, Koorengevel MC, Killian JA.

J Am Chem Soc. 2011 Oct 5;133(39):15598-604. doi: 10.1021/ja205007j. Epub 2011 Sep 9.

PMID:
21870807
9.

Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity.

Last NB, Rhoades E, Miranker AD.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9460-5. doi: 10.1073/pnas.1102356108. Epub 2011 May 23.

10.

Evaluation of membrane models and their composition for islet amyloid polypeptide-membrane aggregation.

Caillon L, Lequin O, Khemtémourian L.

Biochim Biophys Acta. 2013 Sep;1828(9):2091-8. doi: 10.1016/j.bbamem.2013.05.014. Epub 2013 May 23.

11.

Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide.

Williamson JA, Loria JP, Miranker AD.

J Mol Biol. 2009 Oct 23;393(2):383-96. doi: 10.1016/j.jmb.2009.07.077. Epub 2009 Jul 30.

12.

Islet amyloid polypeptide: aggregation and fibrillogenesis in vitro and its inhibition.

Seeliger J, Winter R.

Subcell Biochem. 2012;65:185-209. doi: 10.1007/978-94-007-5416-4_8. Review.

PMID:
23225004
13.

A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes.

Hebda JA, Saraogi I, Magzoub M, Hamilton AD, Miranker AD.

Chem Biol. 2009 Sep 25;16(9):943-50. doi: 10.1016/j.chembiol.2009.08.013.

14.

Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology.

Cao P, Abedini A, Raleigh DP.

Curr Opin Struct Biol. 2013 Feb;23(1):82-9. doi: 10.1016/j.sbi.2012.11.003. Epub 2012 Dec 22. Review.

16.

Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective.

Brender JR, Salamekh S, Ramamoorthy A.

Acc Chem Res. 2012 Mar 20;45(3):454-62. doi: 10.1021/ar200189b. Epub 2011 Sep 25.

17.

Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide.

Magzoub M, Miranker AD.

FASEB J. 2012 Mar;26(3):1228-38. doi: 10.1096/fj.11-194613. Epub 2011 Dec 19.

18.

Effects of cholesterol on pore formation in lipid bilayers induced by human islet amyloid polypeptide fragments: a coarse-grained molecular dynamics study.

Xu W, Wei G, Su H, Nordenskiöld L, Mu Y.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Nov;84(5 Pt 1):051922. Epub 2011 Nov 29.

PMID:
22181459
19.

The role of aromatic side-chains in amyloid growth and membrane interaction of the islet amyloid polypeptide fragment LANFLVH.

Milardi D, Sciacca MF, Pappalardo M, Grasso DM, La Rosa C.

Eur Biophys J. 2011 Jan;40(1):1-12. doi: 10.1007/s00249-010-0623-x. Epub 2010 Sep 1.

PMID:
20809197
20.

Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20-29) fragments.

Brender JR, Heyl DL, Samisetti S, Kotler SA, Osborne JM, Pesaru RR, Ramamoorthy A.

Phys Chem Chem Phys. 2013 Jun 21;15(23):8908-15. doi: 10.1039/c3cp44696d. Epub 2013 Mar 15.

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