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Items: 1 to 20 of 108

1.

DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease.

Barallobre MJ, Perier C, Bové J, Laguna A, Delabar JM, Vila M, Arbonés ML.

Cell Death Dis. 2014 Jun 12;5:e1289. doi: 10.1038/cddis.2014.253.

2.

The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation.

Soppa U, Schumacher J, Florencio Ortiz V, Pasqualon T, Tejedor FJ, Becker W.

Cell Cycle. 2014;13(13):2084-100. doi: 10.4161/cc.29104. Epub 2014 May 7.

3.

The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.

Laguna A, Aranda S, Barallobre MJ, Barhoum R, Fernández E, Fotaki V, Delabar JM, de la Luna S, de la Villa P, Arbonés ML.

Dev Cell. 2008 Dec;15(6):841-53. doi: 10.1016/j.devcel.2008.10.014.

4.

The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice.

Ding YX, Xia Y, Jiao XY, Duan L, Yu J, Wang X, Chen LW.

Neurochem Res. 2011 Oct;36(10):1759-66. doi: 10.1007/s11064-011-0491-5. Epub 2011 May 12.

PMID:
21562748
5.

DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.

Guo X, Williams JG, Schug TT, Li X.

J Biol Chem. 2010 Apr 23;285(17):13223-32. doi: 10.1074/jbc.M110.102574. Epub 2010 Feb 18.

6.

Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease.

Thomas B, Banerjee R, Starkova NN, Zhang SF, Calingasan NY, Yang L, Wille E, Lorenzo BJ, Ho DJ, Beal MF, Starkov A.

Antioxid Redox Signal. 2012 May 1;16(9):855-68. doi: 10.1089/ars.2010.3849. Epub 2011 Jun 16.

7.

Dopaminergic deficiency in mice with reduced levels of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A, Dyrk1A(+/-).

Martinez de Lagran M, Bortolozzi A, Millan O, Gispert JD, Gonzalez JR, Arbones ML, Artigas F, Dierssen M.

Genes Brain Behav. 2007 Aug;6(6):569-78. Epub 2006 Nov 28.

8.

Systemically administered neuregulin-1β1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson's disease.

Depboylu C, Rösler TW, de Andrade A, Oertel WH, Höglinger GU.

J Neurochem. 2015 May;133(4):590-7. doi: 10.1111/jnc.13026. Epub 2015 Jan 26.

PMID:
25581060
9.

The transcription factor Pitx3 is expressed selectively in midbrain dopaminergic neurons susceptible to neurodegenerative stress.

Luk KC, Rymar VV, van den Munckhof P, Nicolau S, Steriade C, Bifsha P, Drouin J, Sadikot AF.

J Neurochem. 2013 Jun;125(6):932-43. doi: 10.1111/jnc.12160. Epub 2013 Mar 6.

10.

Sustained resistance to acute MPTP toxicity by hypothalamic dopamine neurons following chronic neurotoxicant exposure is associated with sustained up-regulation of parkin protein.

Benskey M, Lee KY, Parikh K, Lookingland KJ, Goudreau JL.

Neurotoxicology. 2013 Jul;37:144-53. doi: 10.1016/j.neuro.2013.04.002. Epub 2013 May 1.

11.

Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease.

Liu L, Peritore C, Ginsberg J, Shih J, Arun S, Donmez G.

Behav Brain Res. 2015 Mar 15;281:215-21. doi: 10.1016/j.bbr.2014.12.035. Epub 2014 Dec 23.

PMID:
25541039
12.

Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease.

Noelker C, Morel L, Osterloh A, Alvarez-Fischer D, Lescot T, Breloer M, Gold M, Oertel WH, Henze C, Michel PP, Dodel RC, Lu L, Hirsch EC, Hunot S, Hartmann A.

J Neuroinflammation. 2014 May 8;11:86. doi: 10.1186/1742-2094-11-86.

13.

DYRK1A: a master regulatory protein controlling brain growth.

Guedj F, Pereira PL, Najas S, Barallobre MJ, Chabert C, Souchet B, Sebrie C, Verney C, Herault Y, Arbones M, Delabar JM.

Neurobiol Dis. 2012 Apr;46(1):190-203. doi: 10.1016/j.nbd.2012.01.007. Epub 2012 Jan 26. Erratum in: Neurobiol Dis. 2012 Aug;47(2):294.

PMID:
22293606
14.

Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells.

Park J, Oh Y, Yoo L, Jung MS, Song WJ, Lee SH, Seo H, Chung KC.

J Biol Chem. 2010 Oct 8;285(41):31895-906. doi: 10.1074/jbc.M110.147520. Epub 2010 Aug 9.

15.
16.

DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson's disease.

Kinugawa K, Monnet Y, Béchade C, Alvarez-Fischer D, Hirsch EC, Bessis A, Hunot S.

J Neuroinflammation. 2013 Jul 11;10:82. doi: 10.1186/1742-2094-10-82.

17.

Secalonic acid A protects dopaminergic neurons from 1-methyl-4-phenylpyridinium (MPP⁺)-induced cell death via the mitochondrial apoptotic pathway.

Zhai A, Zhu X, Wang X, Chen R, Wang H.

Eur J Pharmacol. 2013 Aug 5;713(1-3):58-67. doi: 10.1016/j.ejphar.2013.04.029. Epub 2013 May 9.

PMID:
23665112
18.

Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice.

Mazur-Kolecka B, Golabek A, Kida E, Rabe A, Hwang YW, Adayev T, Wegiel J, Flory M, Kaczmarski W, Marchi E, Frackowiak J.

J Neurosci Res. 2012 May;90(5):999-1010. doi: 10.1002/jnr.23007. Epub 2012 Jan 18.

PMID:
22252917
19.

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

Andres-Mateos E, Mejias R, Sasaki M, Li X, Lin BM, Biskup S, Zhang L, Banerjee R, Thomas B, Yang L, Liu G, Beal MF, Huso DL, Dawson TM, Dawson VL.

J Neurosci. 2009 Dec 16;29(50):15846-50. doi: 10.1523/JNEUROSCI.4357-09.2009.

20.

Ablation of serum response factor in dopaminergic neurons exacerbates susceptibility towards MPTP-induced oxidative stress.

Rieker C, Schober A, Bilbao A, Schütz G, Parkitna JR.

Eur J Neurosci. 2012 Mar;35(5):735-41. doi: 10.1111/j.1460-9568.2012.08003.x. Epub 2012 Feb 22.

PMID:
22356487
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