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Items: 1 to 20 of 99


Synthesis of site-specific DNA-protein conjugates and their effects on DNA replication.

Yeo JE, Wickramaratne S, Khatwani S, Wang YC, Vervacke J, Distefano MD, Tretyakova NY.

ACS Chem Biol. 2014 Aug 15;9(8):1860-8. doi: 10.1021/cb5001795. Epub 2014 Jun 26.


DNA-Protein Cross-Links: Formation, Structural Identities, and Biological Outcomes.

Tretyakova NY, Groehler A 4th, Ji S.

Acc Chem Res. 2015 Jun 16;48(6):1631-44. doi: 10.1021/acs.accounts.5b00056. Epub 2015 Jun 2.


Error-prone translesion synthesis past DNA-peptide cross-links conjugated to the major groove of DNA via C5 of thymidine.

Wickramaratne S, Boldry EJ, Buehler C, Wang YC, Distefano MD, Tretyakova NY.

J Biol Chem. 2015 Jan 9;290(2):775-87. doi: 10.1074/jbc.M114.613638. Epub 2014 Nov 12.


Synthesis of sequence-specific DNA-protein conjugates via a reductive amination strategy.

Wickramaratne S, Mukherjee S, Villalta PW, Schärer OD, Tretyakova NY.

Bioconjug Chem. 2013 Sep 18;24(9):1496-506. doi: 10.1021/bc400018u. Epub 2013 Aug 16.


Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family.

Minko IG, Yamanaka K, Kozekov ID, Kozekova A, Indiani C, O'Donnell ME, Jiang Q, Goodman MF, Rizzo CJ, Lloyd RS.

Chem Res Toxicol. 2008 Oct;21(10):1983-90. doi: 10.1021/tx800174a. Epub 2008 Sep 13.


An azide-modified nucleoside for metabolic labeling of DNA.

Neef AB, Luedtke NW.

Chembiochem. 2014 Apr 14;15(6):789-93. doi: 10.1002/cbic.201400037. Epub 2014 Mar 18.


Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal.

Minko IG, Kozekov ID, Harris TM, Rizzo CJ, Lloyd RS, Stone MP.

Chem Res Toxicol. 2009 May;22(5):759-78. doi: 10.1021/tx9000489. Review.


From mechanism to mouse: a tale of two bioorthogonal reactions.

Sletten EM, Bertozzi CR.

Acc Chem Res. 2011 Sep 20;44(9):666-76. doi: 10.1021/ar200148z. Epub 2011 Aug 15.


Click chemistry as a reliable method for the high-density postsynthetic functionalization of alkyne-modified DNA.

Gierlich J, Burley GA, Gramlich PM, Hammond DM, Carell T.

Org Lett. 2006 Aug 17;8(17):3639-42.


Incision of DNA-protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repair.

Minko IG, Zou Y, Lloyd RS.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1905-9. Epub 2002 Feb 12.


Postsynthetic DNA modification through the copper-catalyzed azide-alkyne cycloaddition reaction.

Gramlich PM, Wirges CT, Manetto A, Carell T.

Angew Chem Int Ed Engl. 2008;47(44):8350-8. doi: 10.1002/anie.200802077. Review.


A solid-phase CuAAC strategy for the synthesis of PNA containing nucleobase surrogates.

St Amant AH, Engbers C, Hudson RH.

Artif DNA PNA XNA. 2013 Jan-Mar;4(1):4-10. doi: 10.4161/adna.23982. Epub 2013 Jan 1.


Covalent protein-oligonucleotide conjugates by copper-free click reaction.

Khatwani SL, Kang JS, Mullen DG, Hast MA, Beese LS, Distefano MD, Taton TA.

Bioorg Med Chem. 2012 Jul 15;20(14):4532-9. doi: 10.1016/j.bmc.2012.05.017. Epub 2012 May 17.


Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells.

Nakano T, Katafuchi A, Matsubara M, Terato H, Tsuboi T, Masuda T, Tatsumoto T, Pack SP, Makino K, Croteau DL, Van Houten B, Iijima K, Tauchi H, Ide H.

J Biol Chem. 2009 Oct 2;284(40):27065-76. doi: 10.1074/jbc.M109.019174. Epub 2009 Aug 11.


Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1.

Choi JY, Lim S, Kim EJ, Jo A, Guengerich FP.

J Mol Biol. 2010 Nov 19;404(1):34-44. doi: 10.1016/j.jmb.2010.09.015. Epub 2010 Oct 1.


DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells.

Tretyakova NY, Michaelson-Richie ED, Gherezghiher TB, Kurtz J, Ming X, Wickramaratne S, Campion M, Kanugula S, Pegg AE, Campbell C.

Biochemistry. 2013 May 7;52(18):3171-81. doi: 10.1021/bi400273m. Epub 2013 Apr 24.


Development of copper-catalyzed azide-alkyne cycloaddition for increased in vivo efficacy of interferon β-1b by site-specific PEGylation.

Nairn NW, Shanebeck KD, Wang A, Graddis TJ, VanBrunt MP, Thornton KC, Grabstein K.

Bioconjug Chem. 2012 Oct 17;23(10):2087-97. doi: 10.1021/bc300295x. Epub 2012 Sep 28.

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