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Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1.

Li Y, Wei Z, Zhang J, Yang Z, Zhang M.

J Biol Chem. 2014 May 23;289(21):14674-81. doi: 10.1074/jbc.M114.551184. Epub 2014 Apr 4.


Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.

Li W, You L, Cooper J, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG.

Cell. 2010 Feb 19;140(4):477-90. doi: 10.1016/j.cell.2010.01.029.


Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1).

Li W, Giancotti FG.

Cell Cycle. 2010 Nov 15;9(22):4433-6. Epub 2010 Nov 15.


Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression.

Cooper J, Li W, You L, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG.

Sci Signal. 2011 Aug 23;4(188):pt6. doi: 10.1126/scisignal.2002314.


Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain.

Shimizu T, Seto A, Maita N, Hamada K, Tsukita S, Tsukita S, Hakoshima T.

J Biol Chem. 2002 Mar 22;277(12):10332-6. Epub 2001 Dec 27.


Structural basis for CD44 recognition by ERM proteins.

Mori T, Kitano K, Terawaki S, Maesaki R, Fukami Y, Hakoshima T.

J Biol Chem. 2008 Oct 24;283(43):29602-12. doi: 10.1074/jbc.M803606200. Epub 2008 Aug 27.


Molecular insights into NF2/Merlin tumor suppressor function.

Cooper J, Giancotti FG.

FEBS Lett. 2014 Aug 19;588(16):2743-52. doi: 10.1016/j.febslet.2014.04.001. Epub 2014 Apr 12. Review.


Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor.

Yogesha SD, Sharff AJ, Giovannini M, Bricogne G, Izard T.

Protein Sci. 2011 Dec;20(12):2113-20. doi: 10.1002/pro.751. Epub 2011 Nov 9.


Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.

Li W, Cooper J, Zhou L, Yang C, Erdjument-Bromage H, Zagzag D, Snuderl M, Ladanyi M, Hanemann CO, Zhou P, Karajannis MA, Giancotti FG.

Cancer Cell. 2014 Jul 14;26(1):48-60. doi: 10.1016/j.ccr.2014.05.001.


Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin.

Bai Y, Liu YJ, Wang H, Xu Y, Stamenkovic I, Yu Q.

Oncogene. 2007 Feb 8;26(6):836-50. Epub 2006 Sep 4.


Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of adhesion molecule CD44.

Mori T, Kitano K, Terawaki S, Maesaki R, Hakoshima T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):844-7. Epub 2007 Sep 19.


VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.

Huang J, Chen J.

Oncogene. 2008 Jul 3;27(29):4056-64. doi: 10.1038/onc.2008.44. Epub 2008 Mar 10.


The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1.

Ahn J, Novince Z, Concel J, Byeon CH, Makhov AM, Byeon IJ, Zhang P, Gronenborn AM.

Biochemistry. 2011 Mar 1;50(8):1359-67. doi: 10.1021/bi101749s. Epub 2011 Jan 31.


FERM domain phosphoinositide binding targets merlin to the membrane and is essential for its growth-suppressive function.

Mani T, Hennigan RF, Foster LA, Conrady DG, Herr AB, Ip W.

Mol Cell Biol. 2011 May;31(10):1983-96. doi: 10.1128/MCB.00609-10. Epub 2011 Mar 14.


Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cells.

Lallemand D, Saint-Amaux AL, Giovannini M.

J Cell Sci. 2009 Nov 15;122(Pt 22):4141-9. doi: 10.1242/jcs.045914.


Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest.

Gérard FC, Yang R, Romani B, Poisson A, Belzile JP, Rougeau N, Cohen ÉA.

PLoS One. 2014 Feb 18;9(2):e89195. doi: 10.1371/journal.pone.0089195. eCollection 2014.


Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes.

Zhang Y, Feng S, Chen F, Chen H, Wang J, McCall C, Xiong Y, Deng XW.

Plant Cell. 2008 Jun;20(6):1437-55. doi: 10.1105/tpc.108.058891. Epub 2008 Jun 13.


Structural basis of the cytoplasmic tail of adhesion molecule CD43 and its binding to ERM proteins.

Takai Y, Kitano K, Terawaki S, Maesaki R, Hakoshima T.

J Mol Biol. 2008 Sep 5;381(3):634-44. doi: 10.1016/j.jmb.2008.05.085. Epub 2008 Jun 7.

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