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Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus.

Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O'Keefe RJ, Xing L, Mooney RA, Zuscik MJ.

PLoS One. 2014 Jun 9;9(6):e99656. doi: 10.1371/journal.pone.0099656. eCollection 2014.


Fractures in geriatric mice show decreased callus expansion and bone volume.

Lopas LA, Belkin NS, Mutyaba PL, Gray CF, Hankenson KD, Ahn J.

Clin Orthop Relat Res. 2014 Nov;472(11):3523-32. doi: 10.1007/s11999-014-3829-x. Epub 2014 Aug 9.


Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength.

Morse A, Yu NY, Peacock L, Mikulec K, Kramer I, Kneissel M, McDonald MM, Little DG.

Bone. 2015 Feb;71:155-63. doi: 10.1016/j.bone.2014.10.018. Epub 2014 Oct 30.


Increased fracture callus mineralization and strength in cathepsin K knockout mice.

Gentile MA, Soung do Y, Horrell C, Samadfam R, Drissi H, Duong LT.

Bone. 2014 Sep;66:72-81. doi: 10.1016/j.bone.2014.04.032. Epub 2014 Jun 10. Erratum in: Bone. 2015 Feb;71:264.


Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function.

Morgan EF, Mason ZD, Chien KB, Pfeiffer AJ, Barnes GL, Einhorn TA, Gerstenfeld LC.

Bone. 2009 Feb;44(2):335-44. doi: 10.1016/j.bone.2008.10.039. Epub 2008 Oct 25.


Micro-computed tomography assessment of the progression of fracture healing in mice.

O'Neill KR, Stutz CM, Mignemi NA, Burns MC, Murry MR, Nyman JS, Schoenecker JG.

Bone. 2012 Jun;50(6):1357-67. doi: 10.1016/j.bone.2012.03.008. Epub 2012 Mar 17.


Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing.

Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD.

J Bone Miner Res. 2015 Sep;30(9):1572-84. doi: 10.1002/jbmr.2510.


Fracture healing with alendronate treatment in the Brtl/+ mouse model of osteogenesis imperfecta.

Meganck JA, Begun DL, McElderry JD, Swick A, Kozloff KM, Goldstein SA, Morris MD, Marini JC, Caird MS.

Bone. 2013 Sep;56(1):204-12. doi: 10.1016/j.bone.2013.06.003. Epub 2013 Jun 14.


The anti-diabetic drug metformin does not affect bone mass in vivo or fracture healing.

Jeyabalan J, Viollet B, Smitham P, Ellis SA, Zaman G, Bardin C, Goodship A, Roux JP, Pierre M, Chenu C.

Osteoporos Int. 2013 Oct;24(10):2659-70. doi: 10.1007/s00198-013-2371-0. Epub 2013 May 4.


Obesity does not affect the healing of femur fractures in mice.

Histing T, Andonyan A, Klein M, Scheuer C, Stenger D, Holstein JH, Veith NT, Pohlemann T, Menger MD.

Injury. 2016 Jul;47(7):1435-44. doi: 10.1016/j.injury.2016.04.030. Epub 2016 Apr 23.


Diminished bone formation during diabetic fracture healing is related to the premature resorption of cartilage associated with increased osteoclast activity.

Kayal RA, Tsatsas D, Bauer MA, Allen B, Al-Sebaei MO, Kakar S, Leone CW, Morgan EF, Gerstenfeld LC, Einhorn TA, Graves DT.

J Bone Miner Res. 2007 Apr;22(4):560-8.


Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains.

Sims EK, Hatanaka M, Morris DL, Tersey SA, Kono T, Chaudry ZZ, Day KH, Moss DR, Stull ND, Mirmira RG, Evans-Molina C.

Am J Physiol Endocrinol Metab. 2013 Dec;305(12):E1495-511. doi: 10.1152/ajpendo.00366.2013. Epub 2013 Oct 29.


Differential development of glucose intolerance and pancreatic islet adaptation in multiple diet induced obesity models.

Omar B, Pacini G, Ahrén B.

Nutrients. 2012 Sep 28;4(10):1367-81. doi: 10.3390/nu4101367.


Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice.

Duvall CL, Taylor WR, Weiss D, Wojtowicz AM, Guldberg RE.

J Bone Miner Res. 2007 Feb;22(2):286-97.


The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage has impaired glucose tolerance independent of body weight.

Jelinek D, Castillo JJ, Garver WS.

Gene. 2013 Sep 15;527(1):65-70. doi: 10.1016/j.gene.2013.05.080. Epub 2013 Jun 11.


Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.

Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ.

Bone. 2014 May;62:79-89. doi: 10.1016/j.bone.2014.02.002. Epub 2014 Feb 12.


Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes.

David MA, Jones KH, Inzana JA, Zuscik MJ, Awad HA, Mooney RA.

PLoS One. 2014 Mar 21;9(3):e91234. doi: 10.1371/journal.pone.0091234. eCollection 2014.


Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice.

Yin G, Sheu TJ, Menon P, Pang J, Ho HC, Shi S, Xie C, Smolock E, Yan C, Zuscik MJ, Berk BC.

PLoS One. 2014 Feb 19;9(2):e89127. doi: 10.1371/journal.pone.0089127. eCollection 2014.


Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice.

Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW 3rd, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO.

Osteoporos Int. 2011 Aug;22(8):2283-93. doi: 10.1007/s00198-010-1432-x. Epub 2010 Oct 13.

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