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Items: 1 to 20 of 100

1.

Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion.

Vigueira PA, McCommis KS, Schweitzer GG, Remedi MS, Chambers KT, Fu X, McDonald WG, Cole SL, Colca JR, Kletzien RF, Burgess SC, Finck BN.

Cell Rep. 2014 Jun 26;7(6):2042-53. doi: 10.1016/j.celrep.2014.05.017. Epub 2014 Jun 5.

2.

Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion.

Patterson JN, Cousteils K, Lou JW, Manning Fox JE, MacDonald PE, Joseph JW.

J Biol Chem. 2014 May 9;289(19):13335-46. doi: 10.1074/jbc.M113.521666. Epub 2014 Mar 27.

3.

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.

McCommis KS, Chen Z, Fu X, McDonald WG, Colca JR, Kletzien RF, Burgess SC, Finck BN.

Cell Metab. 2015 Oct 6;22(4):682-94. doi: 10.1016/j.cmet.2015.07.028. Epub 2015 Sep 3.

PMID:
26344101
4.

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.

Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA, Henry RR, McDonald WG, Colca JR, Simon MI, Ciaraldi TP, Murphy AN.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5422-7. doi: 10.1073/pnas.1303360110. Epub 2013 Mar 19.

5.

Pancreatic islet beta-cells transiently metabolize pyruvate.

Rocheleau JV, Head WS, Nicholson WE, Powers AC, Piston DW.

J Biol Chem. 2002 Aug 23;277(34):30914-20. Epub 2002 Jun 17.

6.

Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins.

Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM, Gracheva E, Korshunova Y, Trusgnich M, Karr R, Wiley SE, Divakaruni AS, Murphy AN, Vigueira PA, Finck BN, Kletzien RF.

PLoS One. 2013 May 15;8(5):e61551. doi: 10.1371/journal.pone.0061551. Print 2013.

7.

Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion.

Casimir M, Lasorsa FM, Rubi B, Caille D, Palmieri F, Meda P, Maechler P.

J Biol Chem. 2009 Sep 11;284(37):25004-14. doi: 10.1074/jbc.M109.015495. Epub 2009 Jul 7.

8.

The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion.

Odegaard ML, Joseph JW, Jensen MV, Lu D, Ilkayeva O, Ronnebaum SM, Becker TC, Newgard CB.

J Biol Chem. 2010 May 28;285(22):16530-7. doi: 10.1074/jbc.M109.092593. Epub 2010 Mar 31.

9.

The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells.

Rubi B, del Arco A, Bartley C, Satrustegui J, Maechler P.

J Biol Chem. 2004 Dec 31;279(53):55659-66. Epub 2004 Oct 19.

10.

ß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion.

Srinivasan M, Choi CS, Ghoshal P, Pliss L, Pandya JD, Hill D, Cline G, Patel MS.

Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E910-7. doi: 10.1152/ajpendo.00339.2010. Epub 2010 Sep 14.

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12.

Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

Beall C, Piipari K, Al-Qassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford ML.

Biochem J. 2010 Jul 15;429(2):323-33. doi: 10.1042/BJ20100231.

13.

The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function.

Sener A, Kawazu S, Hutton JC, Boschero AC, Devis G, Somers G, Herchuelz A, Malaisse WJ.

Biochem J. 1978 Oct 15;176(1):217-32.

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16.

Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion.

Zhou YP, Pena JC, Roe MW, Mittal A, Levisetti M, Baldwin AC, Pugh W, Ostrega D, Ahmed N, Bindokas VP, Philipson LH, Hanahan D, Thompson CB, Polonsky KS.

Am J Physiol Endocrinol Metab. 2000 Feb;278(2):E340-51.

17.

Mitochondrial pyruvate transport: a historical perspective and future research directions.

McCommis KS, Finck BN.

Biochem J. 2015 Mar 15;466(3):443-54. doi: 10.1042/BJ20141171. Review.

18.

Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.

Fransson U, Rosengren AH, Schuit FC, Renström E, Mulder H.

Diabetologia. 2006 Jul;49(7):1578-86. Epub 2006 Apr 26.

PMID:
16752176
19.

Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing.

Sekine N, Cirulli V, Regazzi R, Brown LJ, Gine E, Tamarit-Rodriguez J, Girotti M, Marie S, MacDonald MJ, Wollheim CB, et al.

J Biol Chem. 1994 Feb 18;269(7):4895-902.

20.

Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.

Antinozzi PA, Ishihara H, Newgard CB, Wollheim CB.

J Biol Chem. 2002 Apr 5;277(14):11746-55. Epub 2002 Jan 30.

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