Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 94

1.

In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase.

Korotchenko VN, Saydmohammed M, Vollmer LL, Bakan A, Sheetz K, Debiec KT, Greene KA, Agliori CS, Bahar I, Day BW, Vogt A, Tsang M.

Chembiochem. 2014 Jul 7;15(10):1436-45. doi: 10.1002/cbic.201402000. Epub 2014 Jun 6.

2.

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.

Molina G, Vogt A, Bakan A, Dai W, Queiroz de Oliveira P, Znosko W, Smithgall TE, Bahar I, Lazo JS, Day BW, Tsang M.

Nat Chem Biol. 2009 Sep;5(9):680-7. doi: 10.1038/nchembio.190. Epub 2009 Jul 5.

3.
4.

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter.

Ekerot M, Stavridis MP, Delavaine L, Mitchell MP, Staples C, Owens DM, Keenan ID, Dickinson RJ, Storey KG, Keyse SM.

Biochem J. 2008 Jun 1;412(2):287-98. doi: 10.1042/BJ20071512.

5.

Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development.

Li C, Scott DA, Hatch E, Tian X, Mansour SL.

Development. 2007 Jan;134(1):167-76.

6.

Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells.

Zhang Z, Kobayashi S, Borczuk AC, Leidner RS, Laframboise T, Levine AD, Halmos B.

Carcinogenesis. 2010 Apr;31(4):577-86. doi: 10.1093/carcin/bgq020. Epub 2010 Jan 22.

7.

A high-content screening assay in transgenic zebrafish identifies two novel activators of fgf signaling.

Saydmohammed M, Vollmer LL, Onuoha EO, Vogt A, Tsang M.

Birth Defects Res C Embryo Today. 2011 Sep;93(3):281-7. doi: 10.1002/bdrc.20216. Review.

8.

Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear development.

Urness LD, Li C, Wang X, Mansour SL.

Dev Dyn. 2008 Jan;237(1):163-9.

9.

A role for MKP3 in axial patterning of the zebrafish embryo.

Tsang M, Maegawa S, Kiang A, Habas R, Weinberg E, Dawid IB.

Development. 2004 Jun;131(12):2769-79. Epub 2004 May 13.

10.

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity.

Li G, Yu M, Lee WW, Tsang M, Krishnan E, Weyand CM, Goronzy JJ.

Nat Med. 2012 Oct;18(10):1518-24. doi: 10.1038/nm.2963. Epub 2012 Sep 30.

11.

Post-translational regulation of the ERK phosphatase DUSP6/MKP3 by the mTOR pathway.

Bermudez O, Marchetti S, Pagès G, Gimond C.

Oncogene. 2008 Jun 12;27(26):3685-91. doi: 10.1038/sj.onc.1211040. Epub 2008 Jan 28.

PMID:
18223677
12.

Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos.

Shinya M, Koshida S, Sawada A, Kuroiwa A, Takeda H.

Development. 2001 Nov;128(21):4153-64.

13.

Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling.

Liao WH, Cheng CH, Hung KS, Chiu WT, Chen GD, Hwang PP, Hwang SP, Kuan YS, Huang CJ.

Cell Mol Life Sci. 2013 Jul;70(13):2367-81. doi: 10.1007/s00018-013-1259-7. Epub 2013 Jan 30.

14.

SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo.

Jurynec MJ, Grunwald DJ.

Dis Model Mech. 2010 Nov-Dec;3(11-12):733-42. doi: 10.1242/dmm.000703. Epub 2010 Jul 8.

15.

The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.

Vogt A, Tamewitz A, Skoko J, Sikorski RP, Giuliano KA, Lazo JS.

J Biol Chem. 2005 May 13;280(19):19078-86. Epub 2005 Mar 7.

16.

Cell-active dual specificity phosphatase inhibitors identified by high-content screening.

Vogt A, Cooley KA, Brisson M, Tarpley MG, Wipf P, Lazo JS.

Drug Discov Today. 2005 Autumn;Suppl:3-12.

PMID:
23570161
17.

Post-transcriptional regulation of the DUSP6/MKP-3 phosphatase by MEK/ERK signaling and hypoxia.

Bermudez O, Jouandin P, Rottier J, Bourcier C, Pagès G, Gimond C.

J Cell Physiol. 2011 Jan;226(1):276-84. doi: 10.1002/jcp.22339.

PMID:
20665674
18.

Dimerized glycosaminoglycan chains increase FGF signaling during zebrafish development.

Nguyen TK, Tran VM, Sorna V, Eriksson I, Kojima A, Koketsu M, Loganathan D, Kjellén L, Dorsky RI, Chien CB, Kuberan B.

ACS Chem Biol. 2013 May 17;8(5):939-48. doi: 10.1021/cb400132r. Epub 2013 May 7.

PMID:
23614643
19.

Dual-specific phosphatase-6 (Dusp6) and ERK mediate AMPA receptor-induced oligodendrocyte death.

Domercq M, Alberdi E, Sánchez-Gómez MV, Ariz U, Pérez-Samartín A, Matute C.

J Biol Chem. 2011 Apr 1;286(13):11825-36. doi: 10.1074/jbc.M110.153049. Epub 2011 Feb 7.

20.

A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts.

Blüthgen N, Legewie S, Kielbasa SM, Schramme A, Tchernitsa O, Keil J, Solf A, Vingron M, Schäfer R, Herzel H, Sers C.

FEBS J. 2009 Feb;276(4):1024-35. doi: 10.1111/j.1742-4658.2008.06846.x. Epub 2009 Jan 12.

Items per page

Supplemental Content

Write to the Help Desk