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Results: 1 to 20 of 99

1.

Qualification of LSP1-2111 as a Brain Penetrant Group III Metabotropic Glutamate Receptor Orthosteric Agonist.

Cajina M, Nattini M, Song D, Smagin G, Jørgensen EB, Chandrasena G, Bundgaard C, Toft DB, Huang X, Acher F, Doller D.

ACS Med Chem Lett. 2013 Dec 12;5(2):119-23. doi: 10.1021/ml400338f. eCollection 2014 Feb 13.

PMID:
24900783
[PubMed]
2.

Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: implications for Parkinson's disease treatment and dyskinesia.

Bennouar KE, Uberti MA, Melon C, Bacolod MD, Jimenez HN, Cajina M, Kerkerian-Le Goff L, Doller D, Gubellini P.

Neuropharmacology. 2013 Mar;66:158-69. doi: 10.1016/j.neuropharm.2012.03.022. Epub 2012 Apr 3.

PMID:
22491024
[PubMed - indexed for MEDLINE]
3.

The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT₁A signalling.

Wierońska JM, Acher FC, Sławińska A, Gruca P, Lasoń-Tyburkiewicz M, Papp M, Pilc A.

Psychopharmacology (Berl). 2013 Jun;227(4):711-25. doi: 10.1007/s00213-013-3005-0. Epub 2013 Mar 10.

PMID:
23474845
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.

Beurrier C, Lopez S, Révy D, Selvam C, Goudet C, Lhérondel M, Gubellini P, Kerkerian-LeGoff L, Acher F, Pin JP, Amalric M.

FASEB J. 2009 Oct;23(10):3619-28. doi: 10.1096/fj.09-131789. Epub 2009 Jun 12.

PMID:
19525404
[PubMed - indexed for MEDLINE]
Free Article
5.

Amino-pyrrolidine tricarboxylic acids give new insight into group III metabotropic glutamate receptor activation mechanism.

Frauli M, Hubert N, Schann S, Triballeau N, Bertrand HO, Acher F, Neuville P, Pin JP, Prézeau L.

Mol Pharmacol. 2007 Mar;71(3):704-12. Epub 2006 Dec 13.

PMID:
17167031
[PubMed - indexed for MEDLINE]
Free Article
6.

Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia.

Wierońska JM, Stachowicz K, Acher F, Lech T, Pilc A.

Psychopharmacology (Berl). 2012 Apr;220(3):481-94. doi: 10.1007/s00213-011-2502-2. Epub 2011 Sep 28.

PMID:
21952670
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems.

Wierońska JM, Stachowicz K, Pałucha-Poniewiera A, Acher F, Brański P, Pilc A.

Neuropharmacology. 2010 Dec;59(7-8):627-34. doi: 10.1016/j.neuropharm.2010.08.008. Epub 2010 Aug 14.

PMID:
20713068
[PubMed - indexed for MEDLINE]
8.

Inhibitory actions of mGlu4 receptor ligands on cocaine-, but not nicotine-, induced sensitizing and conditioning locomotor responses in rats.

Zaniewska M, Przegaliński E, Filip M, Pilc A, Doller D.

Pharmacol Rep. 2014 Apr;66(2):205-11. doi: 10.1016/j.pharep.2013.12.001. Epub 2014 Mar 2.

PMID:
24911071
[PubMed - in process]
9.

Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors.

Fazio F, Lionetto L, Molinaro G, Bertrand HO, Acher F, Ngomba RT, Notartomaso S, Curini M, Rosati O, Scarselli P, Di Marco R, Battaglia G, Bruno V, Simmaco M, Pin JP, Nicoletti F, Goudet C.

Mol Pharmacol. 2012 May;81(5):643-56. doi: 10.1124/mol.111.074765. Epub 2012 Feb 6.

PMID:
22311707
[PubMed - indexed for MEDLINE]
Free Article
10.

Modulation of glutamate release from parallel fibers by mGlu4 and pre-synaptic GABA(A) receptors.

Antflick JE, Hampson DR.

J Neurochem. 2012 Feb;120(4):552-63. doi: 10.1111/j.1471-4159.2011.07611.x.

PMID:
22145864
[PubMed - indexed for MEDLINE]
11.

Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α.

Jiang JY, Nagaraju M, Meyer RC, Zhang L, Hamelberg D, Hall RA, Brown EM, Conn PJ, Yang JJ.

J Biol Chem. 2014 Jan 17;289(3):1649-61. doi: 10.1074/jbc.M113.507665. Epub 2013 Nov 26.

PMID:
24280223
[PubMed - indexed for MEDLINE]
12.

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.

Goudet C, Vilar B, Courtiol T, Deltheil T, Bessiron T, Brabet I, Oueslati N, Rigault D, Bertrand HO, McLean H, Daniel H, Amalric M, Acher F, Pin JP.

FASEB J. 2012 Apr;26(4):1682-93. doi: 10.1096/fj.11-195941. Epub 2012 Jan 5.

PMID:
22223752
[PubMed - indexed for MEDLINE]
Free Article
13.

Group III Metabotropic Glutamate Receptors: Pharmacology, Physiology and Therapeutic Potential.

Mercier MS, Lodge D.

Neurochem Res. 2014 Aug 22. [Epub ahead of print]

PMID:
25146900
[PubMed - as supplied by publisher]
14.

Recent advances in the drug discovery of metabotropic glutamate receptor 4 (mGluR4) activators for the treatment of CNS and non-CNS disorders.

Célanire S, Campo B.

Expert Opin Drug Discov. 2012 Mar;7(3):261-80. doi: 10.1517/17460441.2012.660914. Epub 2012 Feb 14. Review.

PMID:
22468956
[PubMed - indexed for MEDLINE]
15.

Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators.

Hong SP, Liu KG, Ma G, Sabio M, Uberti MA, Bacolod MD, Peterson J, Zou ZZ, Robichaud AJ, Doller D.

J Med Chem. 2011 Jul 28;54(14):5070-81. doi: 10.1021/jm200290z. Epub 2011 Jul 1.

PMID:
21688779
[PubMed - indexed for MEDLINE]
16.

Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment.

Cuomo D, Martella G, Barabino E, Platania P, Vita D, Madeo G, Selvam C, Goudet C, Oueslati N, Pin JP, Acher F, Pisani A, Beurrier C, Melon C, Kerkerian-Le Goff L, Gubellini P.

J Neurochem. 2009 May;109(4):1096-105. doi: 10.1111/j.1471-4159.2009.06036.x. Epub 2009 Mar 14.

PMID:
19519781
[PubMed - indexed for MEDLINE]
17.

A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo.

Mitsukawa K, Yamamoto R, Ofner S, Nozulak J, Pescott O, Lukic S, Stoehr N, Mombereau C, Kuhn R, McAllister KH, van der Putten H, Cryan JF, Flor PJ.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18712-7. Epub 2005 Dec 9.

PMID:
16339898
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2).

Iacovelli L, Capobianco L, Iula M, Di Giorgi Gerevini V, Picascia A, Blahos J, Melchiorri D, Nicoletti F, De Blasi A.

Mol Pharmacol. 2004 May;65(5):1103-10.

PMID:
15102938
[PubMed - indexed for MEDLINE]
Free Article
19.
20.

Context-dependent regulation of embryonic stem cell differentiation by mGlu4 metabotropic glutamate receptors.

Cappuccio I, Verani R, Spinsanti P, Niccolini C, Gradini R, Costantino S, Nicoletti F, Melchiorri D.

Neuropharmacology. 2006 Sep;51(3):606-11. Epub 2006 Jun 27.

PMID:
16806298
[PubMed - indexed for MEDLINE]

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