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Items: 1 to 20 of 78

1.

Tetrahydroquinoline-derived macrocyclic toolbox: the discovery of antiangiogenesis agents in zebrafish assay.

Reddy Guduru SK, Chamakuri S, Chandrasekar G, Kitambi SS, Arya P.

ACS Med Chem Lett. 2013 May 24;4(7):666-70. doi: 10.1021/ml400026n. eCollection 2013 Jul 11.

2.

Macrocyclic glycohybrid toolbox identifies novel antiangiogenesis agents from zebrafish assay.

Dasari B, Jogula S, Borhade R, Balasubramanian S, Chandrasekar G, Kitambi SS, Arya P.

Org Lett. 2013 Feb 1;15(3):432-5. doi: 10.1021/ol3032297. Epub 2013 Jan 18.

PMID:
23331160
3.
4.

Divergent approach to building a latrunculin family derived hybrid macrocyclic toolbox.

Aeluri M, Dasari B, Arya P.

Org Lett. 2015 Feb 6;17(3):472-5. doi: 10.1021/ol503465p. Epub 2015 Jan 12.

PMID:
25583127
5.

14-Membered macrocyclic ring-derived toolbox: the identification of small molecule inhibitors of angiogenesis and early embryo development in zebrafish assay.

Aeluri M, Pramanik C, Chetia L, Mallurwar NK, Balasubramanian S, Chandrasekar G, Kitambi SS, Arya P.

Org Lett. 2013 Feb 1;15(3):436-9. doi: 10.1021/ol3032126. Epub 2013 Jan 18.

PMID:
23331174
6.
7.

In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent.

Lam IK, Alex D, Wang YH, Liu P, Liu AL, Du GH, Lee SM.

Mol Nutr Food Res. 2012 Jun;56(6):945-56. doi: 10.1002/mnfr.201100680.

PMID:
22707269
8.

Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery.

Crawford AD, Esguerra CV, de Witte PA.

Planta Med. 2008 May;74(6):624-32. doi: 10.1055/s-2008-1034374. Review.

PMID:
18584811
9.

Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics.

Obrecht D, Robinson JA, Bernardini F, Bisang C, DeMarco SJ, Moehle K, Gombert FO.

Curr Med Chem. 2009;16(1):42-65. Review.

PMID:
19149562
10.

Discovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: the nitroindazolinone chemotype.

Marrero-Ponce Y, Siverio-Mota D, Gálvez-Llompart M, Recio MC, Giner RM, García-Domènech R, Torrens F, Arán VJ, Cordero-Maldonado ML, Esguera CV, de Witte PA, Crawford AD.

Eur J Med Chem. 2011 Dec;46(12):5736-53. doi: 10.1016/j.ejmech.2011.07.053. Epub 2011 Aug 17.

PMID:
22000935
11.

Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants.

Crawford AD, Liekens S, Kamuhabwa AR, Maes J, Munck S, Busson R, Rozenski J, Esguerra CV, de Witte PA.

PLoS One. 2011 Feb 17;6(2):e14694. doi: 10.1371/journal.pone.0014694.

12.

From omics to drug metabolism and high content screen of natural product in zebrafish: a new model for discovery of neuroactive compound.

Hung MW, Zhang ZJ, Li S, Lei B, Yuan S, Cui GZ, Man Hoi P, Chan K, Lee SM.

Evid Based Complement Alternat Med. 2012;2012:605303. doi: 10.1155/2012/605303. Epub 2012 Aug 5.

13.

Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor.

Qvit N, Reuveni H, Gazal S, Zundelevich A, Blum G, Niv MY, Feldstein A, Meushar S, Shalev DE, Friedler A, Gilon C.

J Comb Chem. 2008 Mar-Apr;10(2):256-66. doi: 10.1021/cc700113c. Epub 2008 Feb 14.

PMID:
18271560
14.

A solution- and solid-phase approach to tetrahydroquinoline-derived polycyclics having a 10-membered ring.

Khadem S, Joseph R, Rastegar M, Leek DM, Oudatchin KA, Arya P.

J Comb Chem. 2004 Sep-Oct;6(5):724-34.

PMID:
15360207
15.

Discovery of biologically active oncologic and immunologic small molecule therapies using zebrafish: overview and example of modulation of T cell activation.

Trede NS, Heaton W, Ridges S, Sofla H, Cusick M, Bearss D, Jones D, Fujinami RS.

Curr Protoc Pharmacol. 2013 Mar;Chapter 14:Unit14.24. doi: 10.1002/0471141755.ph1424s60.

PMID:
23456612
16.

Solution- and solid-phase synthesis of natural product-like tetrahydroquinoline-based polycyclics having a medium size ring.

Arya P, Couve-Bonnaire S, Durieux P, Laforce D, Kumar R, Leek DM.

J Comb Chem. 2004 Sep-Oct;6(5):735-45.

PMID:
15360208
17.

A macrocyclic peptide that serves as a cocrystallization ligand and inhibits the function of a MATE family transporter.

Hipolito CJ, Tanaka Y, Katoh T, Nureki O, Suga H.

Molecules. 2013 Aug 30;18(9):10514-30. doi: 10.3390/molecules180910514.

18.

Analysis of furo[3,2-c]tetrahydroquinoline and pyrano[3,2-c]tetrahydroquinoline derivatives as antitumor agents and their metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry.

Hou X, Luo H, Zhong H, Wu F, Zhou M, Zhang W, Han X, Yan G, Zhang M, Lu L, Ding Z, He G, Li R.

Rapid Commun Mass Spectrom. 2013 Jun 15;27(11):1222-30. doi: 10.1002/rcm.6562.

PMID:
23650035
19.

Tuning the chiral cavity of macrocyclic receptor for chiral recognition and discrimination.

Ema T, Tanida D, Hamada K, Sakai T.

J Org Chem. 2008 Nov 21;73(22):9129-32. doi: 10.1021/jo801584b. Epub 2008 Oct 17.

PMID:
18925781
20.

Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization.

Feyen F, Cachoux F, Gertsch J, Wartmann M, Altmann KH.

Acc Chem Res. 2008 Jan;41(1):21-31. Epub 2007 Dec 27. Review.

PMID:
18159935
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