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Items: 1 to 20 of 84

1.

A Strategy for Suppressing Redox Stress within Mitochondria.

Arce PM, Khdour OM, Goldschmidt R, Armstrong JS, Hecht SM.

ACS Med Chem Lett. 2011 May 31;2(8):608-13. doi: 10.1021/ml200095w. eCollection 2011 Aug 11.

2.

An optimized pyrimidinol multifunctional radical quencher.

Khdour OM, Arce PM, Roy B, Hecht SM.

ACS Med Chem Lett. 2013 May 28;4(8):724-9. doi: 10.1021/ml400130z. eCollection 2013 Aug 8.

3.

Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia.

Hausse AO, Aggoun Y, Bonnet D, Sidi D, Munnich A, Rötig A, Rustin P.

Heart. 2002 Apr;87(4):346-9.

4.

Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia.

Calabrese V, Lodi R, Tonon C, D'Agata V, Sapienza M, Scapagnini G, Mangiameli A, Pennisi G, Stella AM, Butterfield DA.

J Neurol Sci. 2005 Jun 15;233(1-2):145-62. Review.

PMID:
15896810
5.

Vitamin E succinate protects hepatocytes against the toxic effect of reactive oxygen species generated at mitochondrial complexes I and III by alkylating agents.

Zhang JG, Nicholls-Grzemski FA, Tirmenstein MA, Fariss MW.

Chem Biol Interact. 2001 Dec 21;138(3):267-84.

PMID:
11714483
6.

Pharmacokinetic evaluation of idebenone.

Becker C, Bray-French K, Drewe J.

Expert Opin Drug Metab Toxicol. 2010 Nov;6(11):1437-44. doi: 10.1517/17425255.2010.530656. Review.

PMID:
20955109
7.

Idebenone in Friedreich's ataxia.

Tonon C, Lodi R.

Expert Opin Pharmacother. 2008 Sep;9(13):2327-37. doi: 10.1517/14656566.9.13.2327 . Review.

PMID:
18710357
8.

The effect of idebenone, a coenzyme Q analogue, on hydrophobic bile acid toxicity to isolated rat hepatocytes and hepatic mitochondria.

Shivaram KN, Winklhofer-Roob BM, Straka MS, Devereaux MW, Everson G, Mierau GW, Sokol RJ.

Free Radic Biol Med. 1998 Sep;25(4-5):480-92. Erratum in: Free Radic Biol Med 1998 Oct;25(6):754.

PMID:
9741584
9.
10.

Oxidative stress does not appear to be involved in the aetiology of Friedreich's ataxia.

Macevilly CJ, Muller DP.

Restor Neurol Neurosci. 1997 Jan 1;11(3):131-7. doi: 10.3233/RNN-1997-11303.

PMID:
21551537
11.

A comparison of the relative antioxidant potency of L-ergothioneine and idebenone.

Dong KK, Damaghi N, Kibitel J, Canning MT, Smiles KA, Yarosh DB.

J Cosmet Dermatol. 2007 Sep;6(3):183-8.

PMID:
17760697
12.

A structurally simplified analogue of geldanamycin exhibits neuroprotective activity.

Madathil MM, Khdour OM, Jaruvangsanti J, Hecht SM.

ACS Med Chem Lett. 2013 Jul 25;4(10):953-7. doi: 10.1021/ml400207m. eCollection 2013 Oct 10.

13.

HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone), an anti-lipid-peroxidative compound: its chemical and biochemical characterizations.

Hino T, Kawanishi S, Yasui H, Oka S, Sakurai H.

Biochim Biophys Acta. 1998 Sep 16;1425(1):47-60.

PMID:
9813237
14.

Friedreich's Ataxia: disease mechanisms, antioxidant and Coenzyme Q10 therapy.

Cooper JM, Schapira AH.

Biofactors. 2003;18(1-4):163-71. Review.

PMID:
14695932
16.

Prolonged alpha-tocopherol deficiency decreases oxidative stress and unmasks alpha-tocopherol-dependent regulation of mitochondrial function in the brain.

Cuddihy SL, Ali SS, Musiek ES, Lucero J, Kopp SJ, Morrow JD, Dugan LL.

J Biol Chem. 2008 Mar 14;283(11):6915-24. doi: 10.1074/jbc.M702572200. Epub 2008 Jan 7.

17.

Brain and liver mitochondria isolated from diabetic Goto-Kakizaki rats show different susceptibility to induced oxidative stress.

Santos MS, Santos DL, Palmeira CM, Seiça R, Moreno AJ, Oliveira CR.

Diabetes Metab Res Rev. 2001 May-Jun;17(3):223-30.

PMID:
11424235
18.

Role of mitochondria in oxidative stress and aging.

Lenaz G, Bovina C, D'Aurelio M, Fato R, Formiggini G, Genova ML, Giuliano G, Merlo Pich M, Paolucci U, Parenti Castelli G, Ventura B.

Ann N Y Acad Sci. 2002 Apr;959:199-213. Review.

PMID:
11976197
19.

Stem cells from wildtype and Friedreich's ataxia mice present similar neuroprotective properties in dorsal root ganglia cells.

Jones J, Estirado A, Redondo C, Martinez S.

PLoS One. 2013 May 9;8(5):e62807. doi: 10.1371/journal.pone.0062807. Print 2013.

20.

α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells.

Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J.

J Nutr Biochem. 2010 Dec;21(12):1222-31. doi: 10.1016/j.jnutbio.2009.10.010. Epub 2010 Feb 12.

PMID:
20153624
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