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Dihydromyricetin activates AMP-activated protein kinase and P38(MAPK) exerting antitumor potential in osteosarcoma.

Zhao Z, Yin JQ, Wu MS, Song G, Xie XB, Zou C, Tang Q, Wu Y, Lu J, Wang Y, Wang J, Kang T, Jia Q, Shen J.

Cancer Prev Res (Phila). 2014 Sep;7(9):927-38. doi: 10.1158/1940-6207.CAPR-14-0067. Epub 2014 Jun 3.


Dihydromyricetin ameliorates the oxidative stress response induced by methylglyoxal via the AMPK/GLUT4 signaling pathway in PC12 cells.

Jiang B, Le L, Pan H, Hu K, Xu L, Xiao P.

Brain Res Bull. 2014 Oct;109:117-26. doi: 10.1016/j.brainresbull.2014.10.010. Epub 2014 Oct 27.


Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways.

Liang CZ, Zhang X, Li H, Tao YQ, Tao LJ, Yang ZR, Zhou XP, Shi ZL, Tao HM.

Cancer Biother Radiopharm. 2012 Dec;27(10):701-10. doi: 10.1089/cbr.2012.1245. Epub 2012 Jul 31.


Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line.

Duo J, Ma Y, Wang G, Han X, Zhang C.

DNA Cell Biol. 2013 Apr;32(4):156-64. doi: 10.1089/dna.2012.1926. Epub 2013 Mar 1.


A novel antitumor piperazine alkyl compound causes apoptosis by inducing RhoB expression via ROS‑mediated c‑Abl/p38 MAPK signaling.

Chung KS, Han G, Kim BK, Kim HM, Yang JS, Ahn J, Lee K, Song KB, Won M.

Cancer Chemother Pharmacol. 2013 Dec;72(6):1315-24.


Protoapigenone, a novel flavonoid, induces apoptosis in human prostate cancer cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase 1/2.

Chang HL, Wu YC, Su JH, Yeh YT, Yuan SS.

J Pharmacol Exp Ther. 2008 Jun;325(3):841-9. doi: 10.1124/jpet.107.135442. Epub 2008 Mar 12.


Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism.

Zhang Q, Liu J, Liu B, Xia J, Chen N, Chen X, Cao Y, Zhang C, Lu C, Li M, Zhu R.

Sci Rep. 2014 Apr 10;4:4628. doi: 10.1038/srep04628.


Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway.

Lioni M, Noma K, Snyder A, Klein-Szanto A, Diehl JA, Rustgi AK, Herlyn M, Smalley KS.

Mol Cancer Ther. 2008 Sep;7(9):2866-75. doi: 10.1158/1535-7163.MCT-08-0391.


Bortezomib induces apoptosis and autophagy in osteosarcoma cells through mitogen-activated protein kinase pathway in vitro.

Lou Z, Ren T, Peng X, Sun Y, Jiao G, Lu Q, Zhang S, Lu X, Guo W.

J Int Med Res. 2013 Oct;41(5):1505-19. doi: 10.1177/0300060513490618. Epub 2013 Aug 23.


A novel synthetic derivative of the natural product berbamine inhibits cell viability and induces apoptosis of human osteosarcoma cells, associated with activation of JNK/AP-1 signaling.

Yang F, Nam S, Zhao R, Tian Y, Liu L, Horne DA, Jove R.

Cancer Biol Ther. 2013 Nov;14(11):1024-31. doi: 10.4161/cbt.26045. Epub 2013 Aug 28.


The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 upregulation in osteosarcoma preclinical models.

Pignochino Y, Dell'Aglio C, Basiricò M, Capozzi F, Soster M, Marchiò S, Bruno S, Gammaitoni L, Sangiolo D, Torchiaro E, D'Ambrosio L, Fagioli F, Ferrari S, Alberghini M, Picci P, Aglietta M, Grignani G.

Clin Cancer Res. 2013 Apr 15;19(8):2117-31. doi: 10.1158/1078-0432.CCR-12-2293. Epub 2013 Feb 22.


Phyllostachys edulis extract induces apoptosis signaling in osteosarcoma cells, associated with AMPK activation.

Chou CW, Cheng YW, Tsai CH.

Drug Des Devel Ther. 2014 Sep 24;8:1577-84. doi: 10.2147/DDDT.S69342. eCollection 2014.


The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor.

Chen KT, Hour MJ, Tsai SC, Chung JG, Kuo SC, Lu CC, Chiu YJ, Chuang YH, Yang JS.

Int J Oncol. 2011 Sep;39(3):611-9. doi: 10.3892/ijo.2011.1071. Epub 2011 Jun 8.


Involvement of AMP-activated protein kinase and p38 mitogen-activated protein kinase in 8-Cl-cAMP-induced growth inhibition.

Han JH, Ahn YH, Choi KY, Hong SH.

J Cell Physiol. 2009 Jan;218(1):104-12. doi: 10.1002/jcp.21573.


Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines.

Sau A, Filomeni G, Pezzola S, D'Aguanno S, Tregno FP, Urbani A, Serra M, Pasello M, Picci P, Federici G, Caccuri AM.

Mol Biosyst. 2012 Apr;8(4):994-1006. doi: 10.1039/c1mb05295k. Epub 2011 Nov 9.


Secreted clusterin (sCLU) regulates cell proliferation and chemosensitivity to cisplatin by modulating ERK1/2 signals in human osteosarcoma cells.

Huang H, Wang L, Li M, Wang X, Zhang L.

World J Surg Oncol. 2014 Aug 9;12:255. doi: 10.1186/1477-7819-12-255.


Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis.

Nagalingam A, Arbiser JL, Bonner MY, Saxena NK, Sharma D.

Breast Cancer Res. 2012 Feb 21;14(1):R35.

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