Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 103

Similar articles for PubMed (Select 24892992)

1.

Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase.

Sierecki E, Newton AC.

Biochemistry. 2014 Jun 24;53(24):3971-81. doi: 10.1021/bi500428j. Epub 2014 Jun 12.

2.

Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.

Sierecki E, Sinko W, McCammon JA, Newton AC.

J Med Chem. 2010 Oct 14;53(19):6899-911. doi: 10.1021/jm100331d.

3.

The phosphatase PHLPP controls the cellular levels of protein kinase C.

Gao T, Brognard J, Newton AC.

J Biol Chem. 2008 Mar 7;283(10):6300-11. Epub 2007 Dec 27.

4.

Turning off AKT: PHLPP as a drug target.

Newton AC, Trotman LC.

Annu Rev Pharmacol Toxicol. 2014;54:537-58. doi: 10.1146/annurev-pharmtox-011112-140338. Review.

5.
6.

PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.

Li X, Stevens PD, Liu J, Yang H, Wang W, Wang C, Zeng Z, Schmidt MD, Yang M, Lee EY, Gao T.

Gastroenterology. 2014 May;146(5):1301-12.e1-10. doi: 10.1053/j.gastro.2014.02.003. Epub 2014 Feb 11.

7.

Suppression of survival signalling pathways by the phosphatase PHLPP.

O'Neill AK, Niederst MJ, Newton AC.

FEBS J. 2013 Jan;280(2):572-83. doi: 10.1111/j.1742-4658.2012.08537.x. Epub 2012 Mar 16.

8.

Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2).

Crotty TM, Nakano T, Stafforini DM, Topham MK.

J Biol Chem. 2013 Jan 18;288(3):1439-47. doi: 10.1074/jbc.M112.407379. Epub 2012 Nov 26.

9.

Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.

Warfel NA, Newton AC.

J Biol Chem. 2012 Feb 3;287(6):3610-6. doi: 10.1074/jbc.R111.318675. Epub 2011 Dec 5.

10.

Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance.

Andreozzi F, Procopio C, Greco A, Mannino GC, Miele C, Raciti GA, Iadicicco C, Beguinot F, Pontiroli AE, Hribal ML, Folli F, Sesti G.

Diabetologia. 2011 Jul;54(7):1879-87. doi: 10.1007/s00125-011-2116-6. Epub 2011 Apr 1.

PMID:
21461637
11.

PHLiPPing the switch on Akt and protein kinase C signaling.

Brognard J, Newton AC.

Trends Endocrinol Metab. 2008 Aug;19(6):223-30. doi: 10.1016/j.tem.2008.04.001. Epub 2008 May 27. Review.

12.

Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes.

Jackson TC, Verrier JD, Drabek T, Janesko-Feldman K, Gillespie DG, Uray T, Dezfulian C, Clark RS, Bayir H, Jackson EK, Kochanek PM.

J Pharmacol Exp Ther. 2013 Nov;347(2):516-28. doi: 10.1124/jpet.113.206888. Epub 2013 Sep 10.

13.

Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.

Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3957-65. doi: 10.1073/pnas.1404221111. Epub 2014 Sep 8.

14.
15.

Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.

Brognard J, Niederst M, Reyes G, Warfel N, Newton AC.

J Biol Chem. 2009 May 29;284(22):15215-23. doi: 10.1074/jbc.M901468200. Epub 2009 Mar 26.

16.
17.

The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation.

Nitsche C, Edderkaoui M, Moore RM, Eibl G, Kasahara N, Treger J, Grippo PJ, Mayerle J, Lerch MM, Gukovskaya AS.

Gastroenterology. 2012 Feb;142(2):377-87.e1-5. doi: 10.1053/j.gastro.2011.10.026. Epub 2011 Oct 29.

PMID:
22044669
18.

Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells.

Patterson SJ, Han JM, Garcia R, Assi K, Gao T, O'Neill A, Newton AC, Levings MK.

J Immunol. 2011 May 15;186(10):5533-7. doi: 10.4049/jimmunol.1002126. Epub 2011 Apr 15.

19.

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.

Saavedra A, García-Martínez JM, Xifró X, Giralt A, Torres-Peraza JF, Canals JM, Díaz-Hernández M, Lucas JJ, Alberch J, Pérez-Navarro E.

Cell Death Differ. 2010 Feb;17(2):324-35. doi: 10.1038/cdd.2009.127. Epub 2009 Sep 11.

20.

Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis.

Liu J, Weiss HL, Rychahou P, Jackson LN, Evers BM, Gao T.

Oncogene. 2009 Feb 19;28(7):994-1004. doi: 10.1038/onc.2008.450. Epub 2008 Dec 15.

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk