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Results: 1 to 20 of 97

1.

HuD regulates coding and noncoding RNA to induce APP→Aβ processing.

Kang MJ, Abdelmohsen K, Hutchison ER, Mitchell SJ, Grammatikakis I, Guo R, Noh JH, Martindale JL, Yang X, Lee EK, Faghihi MA, Wahlestedt C, Troncoso JC, Pletnikova O, Perrone-Bizzozero N, Resnick SM, de Cabo R, Mattson MP, Gorospe M.

Cell Rep. 2014 Jun 12;7(5):1401-9. doi: 10.1016/j.celrep.2014.04.050. Epub 2014 May 22.

PMID:
24857657
[PubMed - in process]
Free Article
2.

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.

Eur J Neurosci. 2013 Jun;37(12):1962-9. doi: 10.1111/ejn.12235.

PMID:
23773065
[PubMed - indexed for MEDLINE]
3.

The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis.

Zhao J, O'Connor T, Vassar R.

J Neuroinflammation. 2011 Nov 2;8:150. doi: 10.1186/1742-2094-8-150.

PMID:
22047170
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.

Wu G, Sankaranarayanan S, Hsieh SH, Simon AJ, Savage MJ.

J Neurosci Res. 2011 Jun;89(6):822-32. doi: 10.1002/jnr.22618. Epub 2011 Mar 23.

PMID:
21433051
[PubMed - indexed for MEDLINE]
5.

Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription.

Li Y, Zhou W, Tong Y, He G, Song W.

FASEB J. 2006 Feb;20(2):285-92.

PMID:
16449801
[PubMed - indexed for MEDLINE]
Free Article
6.

Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.

Velliquette RA, O'Connor T, Vassar R.

J Neurosci. 2005 Nov 23;25(47):10874-83. Erratum in: J Neurosci. 2006 Feb 15;26(7):2140-2.

PMID:
16306400
[PubMed - indexed for MEDLINE]
Free Article
7.

MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects.

Long JM, Ray B, Lahiri DK.

J Biol Chem. 2014 Feb 21;289(8):5184-98. doi: 10.1074/jbc.M113.518241. Epub 2013 Dec 18.

PMID:
24352696
[PubMed - indexed for MEDLINE]
8.

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R.

J Neurosci. 2007 Apr 4;27(14):3639-49.

PMID:
17409228
[PubMed - indexed for MEDLINE]
Free Article
9.

Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1.

Zhang M, Deng Y, Luo Y, Zhang S, Zou H, Cai F, Wada K, Song W.

J Neurochem. 2012 Mar;120(6):1129-38. doi: 10.1111/j.1471-4159.2011.07644.x. Epub 2012 Feb 10.

PMID:
22212137
[PubMed - indexed for MEDLINE]
10.

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.

Mao P, Manczak M, Calkins MJ, Truong Q, Reddy TP, Reddy AP, Shirendeb U, Lo HH, Rabinovitch PS, Reddy PH.

Hum Mol Genet. 2012 Jul 1;21(13):2973-90. doi: 10.1093/hmg/dds128. Epub 2012 Apr 5.

PMID:
22492996
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.

Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G.

J Biol Chem. 2011 Jul 22;286(29):26166-77. doi: 10.1074/jbc.M111.260471. Epub 2011 Jun 3.

PMID:
21642424
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein.

Tan JL, Li QX, Ciccotosto GD, Crouch PJ, Culvenor JG, White AR, Evin G.

PLoS One. 2013 Apr 17;8(4):e61246. doi: 10.1371/journal.pone.0061246. Print 2013.

PMID:
23613819
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
[PubMed - indexed for MEDLINE]
14.

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.

Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y.

J Neurochem. 2006 Dec;99(6):1555-63. Epub 2006 Nov 2.

PMID:
17083447
[PubMed - indexed for MEDLINE]
15.

Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1‑AS expression.

Liu T, Huang Y, Chen J, Chi H, Yu Z, Wang J, Chen C.

Mol Med Rep. 2014 Sep;10(3):1275-81. doi: 10.3892/mmr.2014.2351. Epub 2014 Jun 23.

PMID:
24970022
[PubMed - in process]
Free PMC Article
16.

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing.

Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang X, Zhang YW.

Mol Neurodegener. 2012 Jun 18;7:30. doi: 10.1186/1750-1326-7-30.

PMID:
22709416
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production.

Herskowitz JH, Offe K, Deshpande A, Kahn RA, Levey AI, Lah JJ.

Mol Biol Cell. 2012 Jul;23(14):2645-57. doi: 10.1091/mbc.E12-01-0014. Epub 2012 May 23.

PMID:
22621900
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease.

Hampel H, Shen Y.

Scand J Clin Lab Invest. 2009;69(1):8-12. doi: 10.1080/00365510701864610. Review.

PMID:
18609117
[PubMed - indexed for MEDLINE]
19.

Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Chen-Dodson E, Hu B, Wu GX, Price E, Register RB, Lineberger J, Miller R, Tang MJ, Espeseth A, Kahana J, Wolfe A, Crouthamel MC, Sankaranarayanan S, Simon A, Chen L, Lai MT, Pietrak B, DiMuzio J, Li Y, Xu M, Huang Q, Garsky V, Sardana MK, Hazuda DJ.

J Alzheimers Dis. 2005 Apr;7(2):139-48; discussion 173-80.

PMID:
15851852
[PubMed - indexed for MEDLINE]
20.

Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.

Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG.

J Biol Chem. 2010 Sep 3;285(36):27737-44. doi: 10.1074/jbc.M110.117960. Epub 2010 Jul 1.

PMID:
20595388
[PubMed - indexed for MEDLINE]
Free PMC Article

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