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Results: 1 to 20 of 102

1.

Removing T-cell epitopes with computational protein design.

King C, Garza EN, Mazor R, Linehan JL, Pastan I, Pepper M, Baker D.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8577-82. doi: 10.1073/pnas.1321126111. Epub 2014 May 19.

PMID:
24843166
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes.

Mazor R, Eberle JA, Hu X, Vassall AN, Onda M, Beers R, Lee EC, Kreitman RJ, Lee B, Baker D, King C, Hassan R, Benhar I, Pastan I.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8571-6. doi: 10.1073/pnas.1405153111. Epub 2014 May 5.

PMID:
24799704
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice.

Hansen JK, Weldon JE, Xiang L, Beers R, Onda M, Pastan I.

J Immunother. 2010 Apr;33(3):297-304. doi: 10.1097/CJI.0b013e3181cd1164.

PMID:
20445350
[PubMed - indexed for MEDLINE]
4.

Higher cytotoxicity of divalent antibody-toxins than monovalent antibody-toxins.

Won J, Nam P, Lee Y, Choe M.

Biochem Biophys Res Commun. 2009 Apr 24;382(1):15-20. doi: 10.1016/j.bbrc.2009.02.091. Epub 2009 Feb 24.

PMID:
19245794
[PubMed - indexed for MEDLINE]
5.

Influence of structural variations on biological activity of anti-PSMA scFv and immunotoxins targeting prostate cancer.

Bühler P, Wetterauer D, Gierschner D, Wetterauer U, Beile UE, Wolf P.

Anticancer Res. 2010 Sep;30(9):3373-9.

PMID:
20944111
[PubMed - indexed for MEDLINE]
6.

A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer.

Weldon JE, Pastan I.

FEBS J. 2011 Dec;278(23):4683-700. doi: 10.1111/j.1742-4658.2011.08182.x. Epub 2011 Jun 2. Review.

PMID:
21585657
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.

Mazor R, Vassall AN, Eberle JA, Beers R, Weldon JE, Venzon DJ, Tsang KY, Benhar I, Pastan I.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):E3597-603. doi: 10.1073/pnas.1218138109. Epub 2012 Dec 3.

PMID:
23213206
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.

Liu W, Onda M, Kim C, Xiang L, Weldon JE, Lee B, Pastan I.

Protein Eng Des Sel. 2012 Jan;25(1):1-6. doi: 10.1093/protein/gzr053. Epub 2011 Nov 17.

PMID:
22101015
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes.

Onda M, Beers R, Xiang L, Lee B, Weldon JE, Kreitman RJ, Pastan I.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5742-7. doi: 10.1073/pnas.1102746108. Epub 2011 Mar 21.

PMID:
21436054
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Design of a modular immunotoxin connected by polyionic adapter peptides.

Kleinschmidt M, Rudolph R, Lilie H.

J Mol Biol. 2003 Mar 21;327(2):445-52.

PMID:
12628249
[PubMed - indexed for MEDLINE]
11.

An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes.

Onda M, Beers R, Xiang L, Nagata S, Wang QC, Pastan I.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11311-6. doi: 10.1073/pnas.0804851105. Epub 2008 Aug 4.

PMID:
18678888
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Fusion protein vaccine by domains of bacterial exotoxin linked with a tumor antigen generates potent immunologic responses and antitumor effects.

Liao CW, Chen CA, Lee CN, Su YN, Chang MC, Syu MH, Hsieh CY, Cheng WF.

Cancer Res. 2005 Oct 1;65(19):9089-98.

PMID:
16204084
[PubMed - indexed for MEDLINE]
Free Article
13.

Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer.

Baiz D, Hassan S, Choi YA, Flores A, Karpova Y, Yancey D, Pullikuth A, Sui G, Sadelain M, Debinski W, Kulik G.

Neoplasia. 2013 Oct;15(10):1172-83.

PMID:
24204196
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients.

Onda M, Nagata S, FitzGerald DJ, Beers R, Fisher RJ, Vincent JJ, Lee B, Nakamura M, Hwang J, Kreitman RJ, Hassan R, Pastan I.

J Immunol. 2006 Dec 15;177(12):8822-34.

PMID:
17142785
[PubMed - indexed for MEDLINE]
Free Article
15.

Preparation of recombinant atoxic form of exotoxin A from Pseudomonas aeruginosa.

Kaloshin AA, Isakov MA, Mikhailova NA, Vertiev JV.

Bull Exp Biol Med. 2013 Jan;154(3):346-50.

PMID:
23484197
[PubMed - indexed for MEDLINE]
16.

In vivo efficacy of the recombinant anti-CD64 immunotoxin H22(scFv)-ETA' in a human acute myeloid leukemia xenograft tumor model.

Tur MK, Huhn M, Jost E, Thepen T, Brümmendorf TH, Barth S.

Int J Cancer. 2011 Sep 1;129(5):1277-82. doi: 10.1002/ijc.25766. Epub 2011 Feb 26.

PMID:
21077160
[PubMed - indexed for MEDLINE]
17.

[Immunobiological properties of recombinant atoxic forms of the Pseudomonas aeruginosa exotoxin A].

Isakov MA, Soldatenkova AS, Kaloshin AA, Mikhaĭlova NA.

Zh Mikrobiol Epidemiol Immunobiol. 2011 Mar-Apr;(2):37-42. Russian.

PMID:
21598613
[PubMed - indexed for MEDLINE]
18.

Preparation and characterization of fusion protein truncated Pseudomonas Exotoxin A (PE38KDEL) in Escherichia coli.

Song S, Xue J, Fan K, Kou G, Zhou Q, Wang H, Guo Y.

Protein Expr Purif. 2005 Nov;44(1):52-7.

PMID:
15922623
[PubMed - indexed for MEDLINE]
19.

Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies.

Epel M, Carmi I, Soueid-Baumgarten S, Oh SK, Bera T, Pastan I, Berzofsky J, Reiter Y.

Eur J Immunol. 2008 Jun;38(6):1706-20. doi: 10.1002/eji.200737524.

PMID:
18446790
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Is Pseudomonas aeruginosa exotoxin A a good carrier protein for conjugate vaccines?

Pier GB.

Hum Vaccin. 2007 Mar-Apr;3(2):39-40; author reply 41. Epub 2007 Mar 8. No abstract available.

PMID:
17268204
[PubMed - indexed for MEDLINE]
Free Article

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