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Results: 1 to 20 of 102

Similar articles for PubMed (Select 24834870)

1.

Biased ligands: pathway validation for novel GPCR therapeutics.

Rominger DH, Cowan CL, Gowen-MacDonald W, Violin JD.

Curr Opin Pharmacol. 2014 Jun;16:108-15. doi: 10.1016/j.coph.2014.04.002. Epub 2014 May 14. Review.

PMID:
24834870
2.

Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology.

DeWire SM, Violin JD.

Circ Res. 2011 Jul 8;109(2):205-16. doi: 10.1161/CIRCRESAHA.110.231308. Review.

3.

Biasing GPCR signaling from inside.

Shukla AK.

Sci Signal. 2014 Jan 28;7(310):pe3. doi: 10.1126/scisignal.2005021. Review.

PMID:
24473194
4.

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy.

Rahmeh R, Damian M, Cottet M, Orcel H, Mendre C, Durroux T, Sharma KS, Durand G, Pucci B, Trinquet E, Zwier JM, Deupi X, Bron P, Banères JL, Mouillac B, Granier S.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6733-8. doi: 10.1073/pnas.1201093109. Epub 2012 Apr 9.

5.

GPCR biased ligands as novel heart failure therapeutics.

Violin JD, Soergel DG, Boerrigter G, Burnett JC Jr, Lark MW.

Trends Cardiovasc Med. 2013 Oct;23(7):242-9. doi: 10.1016/j.tcm.2013.01.002. Epub 2013 Mar 15. Review.

PMID:
23499300
6.

Bridging the gap: bitopic ligands of G-protein-coupled receptors.

Lane JR, Sexton PM, Christopoulos A.

Trends Pharmacol Sci. 2013 Jan;34(1):59-66. doi: 10.1016/j.tips.2012.10.003. Epub 2012 Nov 20. Review.

PMID:
23177916
7.

Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors.

Southern C, Cook JM, Neetoo-Isseljee Z, Taylor DL, Kettleborough CA, Merritt A, Bassoni DL, Raab WJ, Quinn E, Wehrman TS, Davenport AP, Brown AJ, Green A, Wigglesworth MJ, Rees S.

J Biomol Screen. 2013 Jun;18(5):599-609. doi: 10.1177/1087057113475480. Epub 2013 Feb 8.

PMID:
23396314
8.

Physiological relevance of GPCR oligomerization and its impact on drug discovery.

Panetta R, Greenwood MT.

Drug Discov Today. 2008 Dec;13(23-24):1059-66. doi: 10.1016/j.drudis.2008.09.002. Epub 2008 Oct 14. Review.

PMID:
18824244
9.

Novel insights into biased agonism at G protein-coupled receptors and their potential for drug design.

Martí-Solano M, Guixà-González R, Sanz F, Pastor M, Selent J.

Curr Pharm Des. 2013;19(28):5156-66. Review.

PMID:
23621547
10.

Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors.

Deng H, Sun H, Fang Y.

J Pharmacol Toxicol Methods. 2013 Nov-Dec;68(3):323-33. doi: 10.1016/j.vascn.2013.07.005. Epub 2013 Aug 9.

11.

G-protein-coupled receptor-focused drug discovery using a target class platform approach.

Heilker R, Wolff M, Tautermann CS, Bieler M.

Drug Discov Today. 2009 Mar;14(5-6):231-40. doi: 10.1016/j.drudis.2008.11.011. Epub 2009 Jan 22. Review.

PMID:
19121411
12.

Discovery of GPCR ligands for probing signal transduction pathways.

Brogi S, Tafi A, Désaubry L, Nebigil CG.

Front Pharmacol. 2014 Nov 28;5:255. doi: 10.3389/fphar.2014.00255. eCollection 2014. Review.

13.

Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors.

Reiter E, Ahn S, Shukla AK, Lefkowitz RJ.

Annu Rev Pharmacol Toxicol. 2012;52:179-97. doi: 10.1146/annurev.pharmtox.010909.105800. Epub 2011 Sep 19. Review.

14.

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans.

Amisten S, Salehi A, Rorsman P, Jones PM, Persaud SJ.

Pharmacol Ther. 2013 Sep;139(3):359-91. doi: 10.1016/j.pharmthera.2013.05.004. Epub 2013 May 18. Review.

PMID:
23694765
15.

High throughput screening (HTS) in identification new ligands and drugable targets of G protein-coupled receptors (GPCRs).

Wang D, Li Y, Zhang Y, Liu Y, Shi G.

Comb Chem High Throughput Screen. 2012 Mar;15(3):232-41. Review.

PMID:
22221056
16.

Biased agonism at G protein-coupled receptors: the promise and the challenges--a medicinal chemistry perspective.

Shonberg J, Lopez L, Scammells PJ, Christopoulos A, Capuano B, Lane JR.

Med Res Rev. 2014 Nov;34(6):1286-330. doi: 10.1002/med.21318. Epub 2014 May 5. Review.

PMID:
24796277
17.

Ubiquitination of G protein-coupled receptors: functional implications and drug discovery.

Dores MR, Trejo J.

Mol Pharmacol. 2012 Oct;82(4):563-70. Epub 2012 Jun 14. Review.

18.

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets.

Tang XL, Wang Y, Li DL, Luo J, Liu MY.

Acta Pharmacol Sin. 2012 Mar;33(3):363-71. doi: 10.1038/aps.2011.210. Epub 2012 Feb 27. Review.

19.

Using silico methods predicting ligands for orphan GPCRs.

Jiang Z, Zhou Y.

Curr Protein Pept Sci. 2006 Oct;7(5):459-64. Review.

PMID:
17073696
20.

Refining efficacy: exploiting functional selectivity for drug discovery.

Gesty-Palmer D, Luttrell LM.

Adv Pharmacol. 2011;62:79-107. doi: 10.1016/B978-0-12-385952-5.00009-9. Review.

PMID:
21907907
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