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TRB3 is involved in free fatty acid-induced INS-1-derived cell apoptosis via the protein kinase C δ pathway.

Qin J, Fang N, Lou J, Zhang W, Xu S, Liu H, Fang Q, Wang Z, Liu J, Men X, Peng L, Chen L.

PLoS One. 2014 May 13;9(5):e96089. doi: 10.1371/journal.pone.0096089. eCollection 2014.


Involvement of dynamin-related protein 1 in free fatty acid-induced INS-1-derived cell apoptosis.

Peng L, Men X, Zhang W, Wang H, Xu S, Fang Q, Liu H, Yang W, Lou J.

PLoS One. 2012;7(11):e49258. doi: 10.1371/journal.pone.0049258. Epub 2012 Nov 14. Erratum in: PLoS One. 2013;8(9): doi/10.1371/annotation/831aa38a-a30b-4d47-a4b3-10f5b0709158.


Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells.

Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, Brendel MD, Bretzel RG, Häring HU, Kellerer M.

Diabetes. 2003 Apr;52(4):991-7.


The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.

Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, Wanic K, Malecki M, Warram JH, Qi L, Krolewski AS, Kulkarni RN.

J Clin Invest. 2010 Aug;120(8):2876-88. doi: 10.1172/JCI36849. Epub 2010 Jul 1.


The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells.

Shen X, Yang L, Yan S, Wei W, Liang L, Zheng H, Cai X.

Metabolism. 2014 Mar;63(3):335-51. doi: 10.1016/j.metabol.2013.11.003. Epub 2013 Nov 11.


TRIB3 alters endoplasmic reticulum stress-induced β-cell apoptosis via the NF-κB pathway.

Fang N, Zhang W, Xu S, Lin H, Wang Z, Liu H, Fang Q, Li C, Peng L, Lou J.

Metabolism. 2014 Jun;63(6):822-30. doi: 10.1016/j.metabol.2014.03.003. Epub 2014 Mar 10.


Protective action of liraglutide in beta cells under lipotoxic stress via PI3K/Akt/FoxO1 pathway.

Shao S, Nie M, Chen C, Chen X, Zhang M, Yuan G, Yu X, Yang Y.

J Cell Biochem. 2014 Jun;115(6):1166-75. doi: 10.1002/jcb.24763.


Stress-inducible caspase substrate TRB3 promotes nuclear translocation of procaspase-3.

Shimizu K, Takahama S, Endo Y, Sawasaki T.

PLoS One. 2012;7(8):e42721. doi: 10.1371/journal.pone.0042721. Epub 2012 Aug 9.


Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.


TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver.

Du K, Herzig S, Kulkarni RN, Montminy M.

Science. 2003 Jun 6;300(5625):1574-7.


Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced β-cell apoptosis.

Liu J, Yin F, Xiao H, Guo L, Gao X.

Toxicol In Vitro. 2012 Oct;26(7):1093-7. doi: 10.1016/j.tiv.2012.07.004. Epub 2012 Jul 20.


Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways.

Tuo Y, Wang D, Li S, Chen C.

Endocrine. 2011 Apr;39(2):128-38. doi: 10.1007/s12020-010-9432-3. Epub 2010 Dec 15.


Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor.

Yang Y, Tong Y, Gong M, Lu Y, Wang C, Zhou M, Yang Q, Mao T, Tong N.

Cell Signal. 2014 Feb;26(2):268-78. doi: 10.1016/j.cellsig.2013.11.019. Epub 2013 Nov 21.


Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.

Humphrey RK, Newcomb CJ, Yu SM, Hao E, Yu D, Krajewski S, Du K, Jhala US.

J Biol Chem. 2010 Jul 16;285(29):22426-36. doi: 10.1074/jbc.M110.123786. Epub 2010 Apr 26.


Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response.

Sommerweiss D, Gorski T, Richter S, Garten A, Kiess W.

Biochem Biophys Res Commun. 2013 Nov 29;441(4):770-6. doi: 10.1016/j.bbrc.2013.10.130. Epub 2013 Nov 1.


Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.

Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E540-50. doi: 10.1152/ajpendo.00478.2007. Epub 2008 Jan 15.


Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction.

Hennige AM, Ranta F, Heinzelmann I, Düfer M, Michael D, Braumüller H, Lutz SZ, Lammers R, Drews G, Bosch F, Häring HU, Ullrich S.

Diabetes. 2010 Jan;59(1):119-27. doi: 10.2337/db09-0512. Epub 2009 Oct 13.


Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.

Ranta F, Leveringhaus J, Theilig D, Schulz-Raffelt G, Hennige AM, Hildebrand DG, Handrick R, Jendrossek V, Bosch F, Schulze-Osthoff K, Häring HU, Ullrich S.

PLoS One. 2011;6(12):e28828. doi: 10.1371/journal.pone.0028828. Epub 2011 Dec 27.


Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.

Martinez SC, Tanabe K, Cras-Méneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA.

Diabetes. 2008 Apr;57(4):846-59. doi: 10.2337/db07-0595. Epub 2008 Jan 3.

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