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Items: 1 to 20 of 99


Retinoblastoma protein potentiates the innate immune response in hepatocytes: significance for hepatocellular carcinoma.

Hutcheson J, Bourgo RJ, Balaji U, Ertel A, Witkiewicz AK, Knudsen ES.

Hepatology. 2014 Oct;60(4):1231-40. doi: 10.1002/hep.27217. Epub 2014 Aug 28.


Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.

Rivadeneira DB, Mayhew CN, Thangavel C, Sotillo E, Reed CA, Graña X, Knudsen ES.

Gastroenterology. 2010 May;138(5):1920-30. doi: 10.1053/j.gastro.2010.01.007. Epub 2010 Jan 25.


RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.

Mayhew CN, Carter SL, Fox SR, Sexton CR, Reed CA, Srinivasan SV, Liu X, Wikenheiser-Brokamp K, Boivin GP, Lee JS, Aronow BJ, Thorgeirsson SS, Knudsen ES.

Gastroenterology. 2007 Sep;133(3):976-84. Epub 2007 Jun 20.


Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma.

Saddic LA, Wirt S, Vogel H, Felsher DW, Sage J.

PLoS One. 2011 May 6;6(5):e19758. doi: 10.1371/journal.pone.0019758.


Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

Viatour P, Ehmer U, Saddic LA, Dorrell C, Andersen JB, Lin C, Zmoos AF, Mazur PK, Schaffer BE, Ostermeier A, Vogel H, Sylvester KG, Thorgeirsson SS, Grompe M, Sage J.

J Exp Med. 2011 Sep 26;208(10):1963-76. doi: 10.1084/jem.20110198. Epub 2011 Aug 29.


Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2.

Wang F, Yuan JH, Wang SB, Yang F, Yuan SX, Ye C, Yang N, Zhou WP, Li WL, Li W, Sun SH.

Hepatology. 2014 Oct;60(4):1278-90. doi: 10.1002/hep.27239. Epub 2014 Aug 25.


Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control.

Reed CA, Mayhew CN, McClendon AK, Knudsen ES.

J Biol Chem. 2010 Jan 8;285(2):1089-96. doi: 10.1074/jbc.M109.043380. Epub 2009 Nov 2.


Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis.

Baek HJ, Lim SC, Kitisin K, Jogunoori W, Tang Y, Marshall MB, Mishra B, Kim TH, Cho KH, Kim SS, Mishra L.

Hepatology. 2008 Oct;48(4):1128-37. doi: 10.1002/hep.22460.


Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest.

Sheahan S, Bellamy CO, Dunbar DR, Harrison DJ, Prost S.

BMC Cancer. 2007 Nov 19;7:215.


Modulation of retinoblastoma and retinoblastoma-related proteins in regenerating rat liver and primary hepatocytes.

Fan G, Xu R, Wessendorf MW, Ma X, Kren BT, Steer CJ.

Cell Growth Differ. 1995 Nov;6(11):1463-76.


Expression of p28GANK and its correlation with RB in human hepatocellular carcinoma.

Tan L, Fu XY, Liu SQ, Li HH, Hong Y, Wu MC, Wang HY.

Liver Int. 2005 Jun;25(3):667-76.


RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage.

McClendon AK, Dean JL, Ertel A, Fu Z, Rivadeneira DB, Reed CA, Bourgo RJ, Witkiewicz A, Addya S, Mayhew CN, Grimes HL, Fortina P, Knudsen ES.

Gastroenterology. 2011 Oct;141(4):1439-50. doi: 10.1053/j.gastro.2011.06.046. Epub 2011 Jun 24.


A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.

Woitach JT, Zhang M, Niu CH, Thorgeirsson SS.

Nat Genet. 1998 Aug;19(4):371-4.


The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells.

Louandre C, Marcq I, Bouhlal H, Lachaier E, Godin C, Saidak Z, François C, Chatelain D, Debuysscher V, Barbare JC, Chauffert B, Galmiche A.

Cancer Lett. 2015 Jan 28;356(2 Pt B):971-7. doi: 10.1016/j.canlet.2014.11.014. Epub 2014 Nov 12.


Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function.

Markey MP, Bergseid J, Bosco EE, Stengel K, Xu H, Mayhew CN, Schwemberger SJ, Braden WA, Jiang Y, Babcock GF, Jegga AG, Aronow BJ, Reed MF, Wang JY, Knudsen ES.

Oncogene. 2007 Sep 20;26(43):6307-18. Epub 2007 Apr 23.


Distinct roles for RB loss on cell cycle control, cisplatin response, and immortalization in Schwann cells.

Seeley SL, Bosco EE, Kramer E, Parysek LM, Knudsen ES.

Cancer Lett. 2007 Jan 8;245(1-2):205-17. Epub 2006 Mar 29.


MicroRNA-331-3p promotes proliferation and metastasis of hepatocellular carcinoma by targeting PH domain and leucine-rich repeat protein phosphatase.

Chang RM, Yang H, Fang F, Xu JF, Yang LY.

Hepatology. 2014 Oct;60(4):1251-63. doi: 10.1002/hep.27221. Epub 2014 Aug 21.


Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice.

Wang Z, Yan J, Lin H, Hua F, Wang X, Liu H, Lv X, Yu J, Mi S, Wang J, Hu ZW.

Hepatology. 2013 May;57(5):1869-81. doi: 10.1002/hep.26234. Epub 2013 Apr 5.


The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma.

Ai J, Tang Q, Wu Y, Xu Y, Feng T, Zhou R, Chen Y, Gao X, Zhu Q, Yue X, Pan Q, Xu S, Li J, Huang M, Daugherty-Holtrop J, He Y, Xu HE, Fan J, Ding J, Geng M.

J Natl Cancer Inst. 2011 Nov 16;103(22):1696-712. doi: 10.1093/jnci/djr360. Epub 2011 Oct 24.

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