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Items: 1 to 20 of 100

1.

Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity.

Lang V, Pallara C, Zabala A, Lobato-Gil S, Lopitz-Otsoa F, Farrás R, Hjerpe R, Torres-Ramos M, Zabaleta L, Blattner C, Hay RT, Barrio R, Carracedo A, Fernandez-Recio J, Rodríguez MS, Aillet F.

Mol Oncol. 2014 Jul;8(5):1026-42. doi: 10.1016/j.molonc.2014.04.002. Epub 2014 Apr 13.

2.

Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation.

Hjerpe R, Aillet F, Lopitz-Otsoa F, Lang V, Torres-Ramos M, Farrás R, Hay RT, Rodríguez MS.

Int J Biochem Cell Biol. 2010 May;42(5):725-35. doi: 10.1016/j.biocel.2010.01.010. Epub 2010 Jan 18.

PMID:
20080206
3.

Mdm2 facilitates the association of p53 with the proteasome.

Kulikov R, Letienne J, Kaur M, Grossman SR, Arts J, Blattner C.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10038-43. doi: 10.1073/pnas.0911716107. Epub 2010 May 17.

4.

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.

Rodriguez MS, Desterro JM, Lain S, Lane DP, Hay RT.

Mol Cell Biol. 2000 Nov;20(22):8458-67.

5.

Negative regulation of p53 by Ras superfamily protein RBEL1A.

Lui K, An J, Montalbano J, Shi J, Corcoran C, He Q, Sun H, Sheikh MS, Huang Y.

J Cell Sci. 2013 Jun 1;126(Pt 11):2436-45. doi: 10.1242/jcs.118117. Epub 2013 Apr 9.

6.

Abnormal MDMX degradation in tumor cells due to ARF deficiency.

Li X, Gilkes D, Li B, Cheng Q, Pernazza D, Lawrence H, Lawrence N, Chen J.

Oncogene. 2012 Aug 9;31(32):3721-32. doi: 10.1038/onc.2011.534. Epub 2011 Nov 28.

7.

Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.

Nie J, Xie P, Liu L, Xing G, Chang Z, Yin Y, Tian C, He F, Zhang L.

J Biol Chem. 2010 Jul 23;285(30):22818-30. doi: 10.1074/jbc.M110.126920. Epub 2010 May 18.

8.
9.
10.

p53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2.

Xian L, Zhao J, Wang J, Fang Z, Peng B, Wang W, Ji X, Yu L.

Mol Biol Rep. 2010 Jul;37(6):2935-40. doi: 10.1007/s11033-009-9855-1. Epub 2009 Oct 16.

PMID:
19842060
11.

Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation.

Calao M, Sekyere EO, Cui HJ, Cheung BB, Thomas WD, Keating J, Chen JB, Raif A, Jankowski K, Davies NP, Bekkum MV, Chen B, Tan O, Ellis T, Norris MD, Haber M, Kim ES, Shohet JM, Trahair TN, Liu T, Wainwright BJ, Ding HF, Marshall GM.

Oncogene. 2013 Aug 1;32(31):3616-26. doi: 10.1038/onc.2012.368. Epub 2012 Aug 20.

PMID:
22907436
12.

p53 regulation by ubiquitin.

Brooks CL, Gu W.

FEBS Lett. 2011 Sep 16;585(18):2803-9. doi: 10.1016/j.febslet.2011.05.022. Epub 2011 May 27. Review.

13.

Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.

Wang KS, Chen G, Shen HL, Li TT, Chen F, Wang QW, Wang ZQ, Han ZG, Zhang X.

PLoS One. 2011;6(8):e23571. doi: 10.1371/journal.pone.0023571. Epub 2011 Aug 24.

14.

XPC promotes MDM2-mediated degradation of the p53 tumor suppressor.

Krzeszinski JY, Choe V, Shao J, Bao X, Cheng H, Luo S, Huo K, Rao H.

Mol Biol Cell. 2014 Jan;25(2):213-21. doi: 10.1091/mbc.E13-05-0293. Epub 2013 Nov 20.

15.

Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53.

Hafsi H, Santos-Silva D, Courtois-Cox S, Hainaut P.

BMC Cancer. 2013 Mar 20;13:134. doi: 10.1186/1471-2407-13-134.

16.

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.

Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA.

Cancer Cell. 2007 Oct;12(4):342-54.

17.
18.

Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain.

Bernard X, Robinson P, Nominé Y, Masson M, Charbonnier S, Ramirez-Ramos JR, Deryckere F, Travé G, Orfanoudakis G.

PLoS One. 2011;6(10):e25981. doi: 10.1371/journal.pone.0025981. Epub 2011 Oct 27.

19.

The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.

Sparks A, Dayal S, Das J, Robertson P, Menendez S, Saville MK.

Oncogene. 2014 Sep 18;33(38):4685-96. doi: 10.1038/onc.2013.413. Epub 2013 Oct 14.

20.

Mechanistic studies of MDM2-mediated ubiquitination in p53 regulation.

Brooks CL, Li M, Gu W.

J Biol Chem. 2007 Aug 3;282(31):22804-15. Epub 2007 May 11.

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