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Results: 1 to 20 of 102

1.

Non-clinical pharmacokinetics and pharmacodynamics of rVIII-SingleChain, a novel recombinant single-chain factor VIII.

Zollner S, Raquet E, Claar P, Müller-Cohrs J, Metzner HJ, Weimer T, Pragst I, Dickneite G, Schulte S.

Thromb Res. 2014 Jul;134(1):125-31. doi: 10.1016/j.thromres.2014.03.028. Epub 2014 Mar 19.

PMID:
24814969
[PubMed - in process]
Free Article
2.

Preclinical efficacy and safety of rVIII-SingleChain (CSL627), a novel recombinant single-chain factor VIII.

Zollner SB, Raquet E, Müller-Cohrs J, Metzner HJ, Weimer T, Pragst I, Dickneite G, Schulte S.

Thromb Res. 2013 Aug;132(2):280-7. doi: 10.1016/j.thromres.2013.06.017. Epub 2013 Jul 5.

PMID:
23830969
[PubMed - indexed for MEDLINE]
Free Article
3.
4.

Pharmacokinetics and pharmacodynamics of a new recombinant FVIII (N8) in haemophilia A mice.

Elm T, Karpf DM, Øvlisen K, Pelzer H, Ezban M, Kjalke M, Tranholm M.

Haemophilia. 2012 Jan;18(1):139-45. doi: 10.1111/j.1365-2516.2011.02608.x. Epub 2011 Jul 19.

PMID:
21771205
[PubMed - indexed for MEDLINE]
5.

Pharmacokinetics and ex vivo whole blood clot formation of a new recombinant FVIII (N8) in haemophilia A dogs.

Karpf DM, Kjalke M, Thim L, Agersø H, Merricks EP, Defriess N, Nichols TC, Ezban M.

Haemophilia. 2011 Sep;17(5):e963-8. doi: 10.1111/j.1365-2516.2011.02580.x. Epub 2011 Jun 20.

PMID:
21682818
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Presurgical pharmacokinetic analysis of a von Willebrand factor/factor VIII (VWF/FVIII) concentrate in patients with von Willebrand's disease (VWD) has limited value in dosing for surgery.

Di Paola J, Lethagen S, Gill J, Mannucci P, Manco-Johnson M, Bernstein J, Nichols WL, Bergman GE.

Haemophilia. 2011 Sep;17(5):752-8. doi: 10.1111/j.1365-2516.2011.02583.x. Epub 2011 Jun 20.

PMID:
21689209
[PubMed - indexed for MEDLINE]
7.

Functional characteristics of N8, a new recombinant FVIII.

Christiansen ML, Balling KW, Persson E, Hilden I, Bagger-Sørensen A, Sørensen BB, Viuff D, Segel S, Klausen NK, Ezban M, Lethagen S, Steenstrup TD, Kjalke M.

Haemophilia. 2010 Nov;16(6):878-87. doi: 10.1111/j.1365-2516.2010.02333.x.

PMID:
20546031
[PubMed - indexed for MEDLINE]
8.

Biochemical and functional characterization of a recombinant monomeric factor VIII-Fc fusion protein.

Peters RT, Toby G, Lu Q, Liu T, Kulman JD, Low SC, Bitonti AJ, Pierce GF.

J Thromb Haemost. 2013 Jan;11(1):132-41. doi: 10.1111/jth.12076.

PMID:
23205847
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII.

Pittman DD, Alderman EM, Tomkinson KN, Wang JH, Giles AR, Kaufman RJ.

Blood. 1993 Jun 1;81(11):2925-35.

PMID:
8499631
[PubMed - indexed for MEDLINE]
Free Article
10.

Pharmacokinetics of coagulation factors: clinical relevance for patients with haemophilia.

Björkman S, Berntorp E.

Clin Pharmacokinet. 2001;40(11):815-32. Review.

PMID:
11735604
[PubMed - indexed for MEDLINE]
11.

The pharmacokinetic diversity of two von Willebrand factor (VWF)/ factor VIII (FVIII) concentrates in subjects with congenital von Willebrand disease. Results from a prospective, randomised crossover study.

Kessler CM, Friedman K, Schwartz BA, Gill JC, Powell JS; Wilate PK Study Investigators.

Thromb Haemost. 2011 Aug;106(2):279-88. doi: 10.1160/TH11-02-0057. Epub 2011 Jul 4.

PMID:
21725579
[PubMed - indexed for MEDLINE]
12.

Development and characterization of recombinant ovine coagulation factor VIII.

Zakas PM, Gangadharan B, Almeida-Porada G, Porada CD, Spencer HT, Doering CB.

PLoS One. 2012;7(11):e49481. doi: 10.1371/journal.pone.0049481. Epub 2012 Nov 9.

PMID:
23152911
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Functional characteristics of the novel, human-derived recombinant FVIII protein product, human-cl rhFVIII.

Sandberg H, Kannicht C, Stenlund P, Dadaian M, Oswaldsson U, Cordula C, Walter O.

Thromb Res. 2012 Nov;130(5):808-17. doi: 10.1016/j.thromres.2012.08.311. Epub 2012 Sep 23.

PMID:
23010293
[PubMed - indexed for MEDLINE]
14.

Bleeding prophylaxis for major surgery in patients with type 2 von Willebrand disease with an intermediate purity factor VIII-von Willebrand factor concentrate (Haemate-P).

Michiels JJ, Berneman ZN, van der Planken M, Schroyens W, Budde U, van Vliet HH.

Blood Coagul Fibrinolysis. 2004 Jun;15(4):323-30.

PMID:
15166918
[PubMed - indexed for MEDLINE]
15.

Kinetics of the interaction between anti-FVIII antibodies and FVIII from therapeutic concentrates, with and without von Willebrand factor, assessed by surface plasmon resonance.

Grancha S, Ortiz AM, Marañón C, Hampel K, Moret A, Zimmermann B, Jorquera JI, Aznar JA.

Haemophilia. 2012 Nov;18(6):982-9. doi: 10.1111/j.1365-2516.2012.02858.x. Epub 2012 May 30.

PMID:
22646163
[PubMed - indexed for MEDLINE]
16.

Pharmacokinetics of monoclonally-purified and recombinant factor VIII in patients with severe von Willebrand disease.

Morfini M, Mannucci PM, Tenconi PM, Longo G, Mazzucconi MG, Rodeghiero F, Ciavarella N, De Rosa V, Arter A.

Thromb Haemost. 1993 Aug 2;70(2):270-2.

PMID:
8236134
[PubMed - indexed for MEDLINE]
17.

von Willebrand factor in factor VIII concentrates protects against neutralization by factor VIII antibodies of haemophilia A patients.

Kallas A, Talpsep T.

Haemophilia. 2001 Jul;7(4):375-80.

PMID:
11442642
[PubMed - indexed for MEDLINE]
18.

Comparison of the pharmacokinetics of two von Willebrand factor concentrates [Biostate and AHF (High Purity)] in people with von Willebrand disorder. A randomised cross-over, multi-centre study.

Favaloro EJ, Lloyd J, Rowell J, Baker R, Rickard K, Kershaw G, Street A, Scarff K, Barrese G, Maher D, McLachlan AJ.

Thromb Haemost. 2007 Jun;97(6):922-30.

PMID:
17549293
[PubMed - indexed for MEDLINE]
19.

Clinical and biological evaluation in von Willebrand's disease of a von Willebrand factor concentrate with low factor VIII activity.

Goudemand J, Mazurier C, Marey A, Caron C, Coupez B, Mizon P, Goudemand M.

Br J Haematol. 1992 Feb;80(2):214-21.

PMID:
1550779
[PubMed - indexed for MEDLINE]
20.

Management of bleeding disorders: basic science.

Ofosu FA, Santagostino E, Grancha S, Marco P.

Haemophilia. 2012 May;18 Suppl 2:8-14. doi: 10.1111/j.1365-2516.2012.02795.x. Review.

PMID:
22530574
[PubMed - indexed for MEDLINE]

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