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Results: 1 to 20 of 94

1.

Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing.

Bouter Y, Kacprowski T, Weissmann R, Dietrich K, Borgers H, Brauß A, Sperling C, Wirths O, Albrecht M, Jensen LR, Kuss AW, Bayer TA.

Front Aging Neurosci. 2014 Apr 16;6:75. doi: 10.3389/fnagi.2014.00075. eCollection 2014.

PMID:
24795628
[PubMed]
Free PMC Article
2.

Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice.

Devi L, Ohno M.

Eur J Neurosci. 2010 Jan;31(1):110-8. doi: 10.1111/j.1460-9568.2009.07031.x. Epub 2009 Dec 21.

PMID:
20092558
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R.

J Neurosci. 2006 Oct 4;26(40):10129-40.

PMID:
17021169
[PubMed - indexed for MEDLINE]
Free Article
4.

Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation.

Eimer WA, Vassar R.

Mol Neurodegener. 2013 Jan 14;8:2. doi: 10.1186/1750-1326-8-2.

PMID:
23316765
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease.

Jawhar S, Trawicka A, Jenneckens C, Bayer TA, Wirths O.

Neurobiol Aging. 2012 Jan;33(1):196.e29-40. doi: 10.1016/j.neurobiolaging.2010.05.027. Epub 2010 Jul 9.

PMID:
20619937
[PubMed - indexed for MEDLINE]
6.

N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody.

Antonios G, Saiepour N, Bouter Y, Richard BC, Paetau A, Verkkoniemi-Ahola A, Lannfelt L, Ingelsson M, Kovacs GG, Pillot T, Wirths O, Bayer TA.

Acta Neuropathol Commun. 2013 Sep 6;1(1):56. doi: 10.1186/2051-5960-1-56.

PMID:
24252153
[PubMed]
Free PMC Article
7.

N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits.

Bouter Y, Dietrich K, Wittnam JL, Rezaei-Ghaleh N, Pillot T, Papot-Couturier S, Lefebvre T, Sprenger F, Wirths O, Zweckstetter M, Bayer TA.

Acta Neuropathol. 2013 Aug;126(2):189-205. doi: 10.1007/s00401-013-1129-2. Epub 2013 May 18.

PMID:
23685882
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease.

Dong H, Csernansky CA, Martin MV, Bertchume A, Vallera D, Csernansky JG.

Psychopharmacology (Berl). 2005 Aug;181(1):145-52. Epub 2005 Oct 15.

PMID:
15778881
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.

Kimura R, Devi L, Ohno M.

J Neurochem. 2010 Apr;113(1):248-61. doi: 10.1111/j.1471-4159.2010.06608.x. Epub 2010 Jan 20.

PMID:
20089133
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease.

Moon M, Hong HS, Nam DW, Baik SH, Song H, Kook SY, Kim YS, Lee J, Mook-Jung I.

J Alzheimers Dis. 2012;29(3):615-28. doi: 10.3233/JAD-2011-111778.

PMID:
22269161
[PubMed - indexed for MEDLINE]
11.

7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease.

Devi L, Ohno M.

Neuropsychopharmacology. 2012 Jan;37(2):434-44. doi: 10.1038/npp.2011.191. Epub 2011 Sep 7.

PMID:
21900882
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF.

Eur J Neurosci. 2006 Jan;23(1):251-60.

PMID:
16420434
[PubMed - indexed for MEDLINE]
13.

Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice.

Devi L, Ohno M.

PLoS One. 2010 Sep 23;5(9):e12974. doi: 10.1371/journal.pone.0012974.

PMID:
20886088
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Behavioral and EEG changes in male 5xFAD mice.

Schneider F, Baldauf K, Wetzel W, Reymann KG.

Physiol Behav. 2014 Aug;135:25-33. doi: 10.1016/j.physbeh.2014.05.041. Epub 2014 Jun 4.

PMID:
24907698
[PubMed - in process]
15.

Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease.

Girard SD, Jacquet M, Baranger K, Migliorati M, Escoffier G, Bernard A, Khrestchatisky M, Féron F, Rivera S, Roman FS, Marchetti E.

Hippocampus. 2014 Jul;24(7):762-72. doi: 10.1002/hipo.22267. Epub 2014 Mar 14.

PMID:
24596271
[PubMed - in process]
16.

Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease.

Devi L, Ohno M.

Transl Psychiatry. 2013 Jul 23;3:e284. doi: 10.1038/tp.2013.59.

PMID:
23880880
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine.

Nagakura A, Shitaka Y, Yarimizu J, Matsuoka N.

Eur J Pharmacol. 2013 Mar 5;703(1-3):53-61. doi: 10.1016/j.ejphar.2012.12.023. Epub 2012 Dec 28.

PMID:
23276665
[PubMed - indexed for MEDLINE]
18.

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice.

Ohno M, Cole SL, Yasvoina M, Zhao J, Citron M, Berry R, Disterhoft JF, Vassar R.

Neurobiol Dis. 2007 Apr;26(1):134-45. Epub 2006 Dec 20.

PMID:
17258906
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.

Youmans KL, Tai LM, Kanekiyo T, Stine WB Jr, Michon SC, Nwabuisi-Heath E, Manelli AM, Fu Y, Riordan S, Eimer WA, Binder L, Bu G, Yu C, Hartley DM, LaDu MJ.

Mol Neurodegener. 2012 Mar 16;7:8. doi: 10.1186/1750-1326-7-8.

PMID:
22423893
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease.

Rothman SM, Herdener N, Frankola KA, Mughal MR, Mattson MP.

Brain Res. 2013 Sep 5;1529:200-8. doi: 10.1016/j.brainres.2013.07.010. Epub 2013 Jul 13.

PMID:
23856323
[PubMed - indexed for MEDLINE]

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