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Results: 1 to 20 of 95

1.

Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.

Shang E, Wu Y, Liu P, Liu Y, Zhu W, Deng X, He C, He S, Li C, Lai L.

Bioorg Med Chem Lett. 2014 Jun 15;24(12):2764-7. doi: 10.1016/j.bmcl.2014.04.006. Epub 2014 Apr 13.

PMID:
24794107
[PubMed - in process]
2.

Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX).

Liedtke AJ, Keck PR, Lehmann F, Koeberle A, Werz O, Laufer SA.

J Med Chem. 2009 Aug 13;52(15):4968-72. doi: 10.1021/jm900481c.

PMID:
19719242
[PubMed - indexed for MEDLINE]
3.

Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes.

Chen SH, Fahmi H, Shi Q, Benderdour M.

Arthritis Res Ther. 2010;12(1):R21. doi: 10.1186/ar2926. Epub 2010 Feb 9.

PMID:
20144213
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.

Schaible AM, Traber H, Temml V, Noha SM, Filosa R, Peduto A, Weinigel C, Barz D, Schuster D, Werz O.

Biochem Pharmacol. 2013 Aug 15;86(4):476-86. doi: 10.1016/j.bcp.2013.04.015. Epub 2013 Apr 24.

PMID:
23623753
[PubMed - indexed for MEDLINE]
5.

Munronia pinnata (Wall.) Theob.: unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1.

Napagoda M, Gerstmeier J, Koeberle A, Wesely S, Popella S, Lorenz S, Scheubert K, Böcker S, Svatoš A, Werz O.

J Ethnopharmacol. 2014 Feb 3;151(2):882-90. doi: 10.1016/j.jep.2013.11.052. Epub 2013 Dec 4.

PMID:
24315851
[PubMed - indexed for MEDLINE]
6.

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.

Hanke T, Dehm F, Liening S, Popella SD, Maczewsky J, Pillong M, Kunze J, Weinigel C, Barz D, Kaiser A, Wurglics M, Lämmerhofer M, Schneider G, Sautebin L, Schubert-Zsilavecz M, Werz O.

J Med Chem. 2013 Nov 27;56(22):9031-44. doi: 10.1021/jm401557w. Epub 2013 Nov 15.

PMID:
24171493
[PubMed - indexed for MEDLINE]
7.

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.

Greiner C, Zettl H, Koeberle A, Pergola C, Northoff H, Schubert-Zsilavecz M, Werz O.

Bioorg Med Chem. 2011 Jun 1;19(11):3394-401. doi: 10.1016/j.bmc.2011.04.034. Epub 2011 Apr 22.

PMID:
21570310
[PubMed - indexed for MEDLINE]
8.

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O.

J Pharmacol Exp Ther. 2010 Mar;332(3):840-8. doi: 10.1124/jpet.109.160663. Epub 2009 Nov 24.

PMID:
19934399
[PubMed - indexed for MEDLINE]
Free Article
9.

Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.

De Simone R, Chini MG, Bruno I, Riccio R, Mueller D, Werz O, Bifulco G.

J Med Chem. 2011 Mar 24;54(6):1565-75. doi: 10.1021/jm101238d. Epub 2011 Feb 16.

PMID:
21323313
[PubMed - indexed for MEDLINE]
10.

Effects of novel diarylpentanoid analogues of curcumin on secretory phospholipase A2 , cyclooxygenases, lipo-oxygenase, and microsomal prostaglandin E synthase-1.

Ahmad W, Kumolosasi E, Jantan I, Bukhari SN, Jasamai M.

Chem Biol Drug Des. 2014 Jun;83(6):670-81. doi: 10.1111/cbdd.12280. Epub 2014 May 14.

PMID:
24406103
[PubMed - in process]
11.

Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.

Wu Y, He C, Gao Y, He S, Liu Y, Lai L.

J Med Chem. 2012 Mar 22;55(6):2597-605. doi: 10.1021/jm201497k. Epub 2012 Mar 1.

PMID:
22380511
[PubMed - indexed for MEDLINE]
12.

Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.

Tan CM, Chen GS, Chen CS, Chang PT, Chern JW.

Bioorg Med Chem. 2011 Nov 1;19(21):6316-28. doi: 10.1016/j.bmc.2011.09.003. Epub 2011 Sep 10.

PMID:
21958737
[PubMed - indexed for MEDLINE]
13.

Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.

Hieke M, Greiner C, Dittrich M, Reisen F, Schneider G, Schubert-Zsilavecz M, Werz O.

J Med Chem. 2011 Jul 14;54(13):4490-507. doi: 10.1021/jm200092b. Epub 2011 Jun 8.

PMID:
21591611
[PubMed - indexed for MEDLINE]
14.

Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.

Chini MG, De Simone R, Bruno I, Riccio R, Dehm F, Weinigel C, Barz D, Werz O, Bifulco G.

Eur J Med Chem. 2012 Aug;54:311-23. doi: 10.1016/j.ejmech.2012.05.014. Epub 2012 May 18.

PMID:
22683242
[PubMed - indexed for MEDLINE]
15.

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.

Koeberle A, Haberl EM, Rossi A, Pergola C, Dehm F, Northoff H, Troschuetz R, Sautebin L, Werz O.

Bioorg Med Chem. 2009 Dec 1;17(23):7924-32. doi: 10.1016/j.bmc.2009.10.025. Epub 2009 Oct 31.

PMID:
19884011
[PubMed - indexed for MEDLINE]
16.

Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression.

Guerrero MD, Aquino M, Bruno I, Riccio R, Terencio MC, Payá M.

Eur J Pharmacol. 2009 Oct 12;620(1-3):112-9. doi: 10.1016/j.ejphar.2009.08.007. Epub 2009 Aug 15.

PMID:
19686718
[PubMed - indexed for MEDLINE]
17.

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Zettl H, Greiner C, Wurglics M, Schubert-Zsilavecz M, Werz O.

J Med Chem. 2008 Dec 25;51(24):8068-76. doi: 10.1021/jm801085s.

PMID:
19053751
[PubMed - indexed for MEDLINE]
18.

Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition.

Hanke T, Lamers C, Gomez RC, Schneider G, Werz O, Schubert-Zsilavecz M.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3757-63. doi: 10.1016/j.bmcl.2014.06.077. Epub 2014 Jul 3.

PMID:
25037914
[PubMed - in process]
19.

A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm.

Revermann M, Mieth A, Popescu L, Paulke A, Wurglics M, Pellowska M, Fischer AS, Steri R, Maier TJ, Schermuly RT, Geisslinger G, Schubert-Zsilavecz M, Brandes RP, Steinhilber D.

Br J Pharmacol. 2011 Aug;163(8):1721-32. doi: 10.1111/j.1476-5381.2011.01321.x.

PMID:
21410457
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Discovery of highly potent microsomal prostaglandin e2 synthase 1 inhibitors using the active conformation structural model and virtual screen.

He S, Li C, Liu Y, Lai L.

J Med Chem. 2013 Apr 25;56(8):3296-309. doi: 10.1021/jm301900x. Epub 2013 Apr 5.

PMID:
23527738
[PubMed - indexed for MEDLINE]

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