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Endocardial focal activation originating from Purkinje fibers plays a role in the maintenance of long duration ventricular fibrillation.

Lin C, Jin Q, Zhang N, Zhou J, Pang Y, Xin Y, Liu S, Wu Q, Wu L.

Croat Med J. 2014 Apr;55(2):121-7.


Chemical ablation of the Purkinje system causes early termination and activation rate slowing of long-duration ventricular fibrillation in dogs.

Dosdall DJ, Tabereaux PB, Kim JJ, Walcott GP, Rogers JM, Killingsworth CR, Huang J, Robertson PG, Smith WM, Ideker RE.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H883-9. doi: 10.1152/ajpheart.00466.2008. Epub 2008 Jun 27.


Periods of highly synchronous, non-reentrant endocardial activation cycles occur during long-duration ventricular fibrillation.

Robichaux RP, Dosdall DJ, Osorio J, Garner NW, Li L, Huang J, Ideker RE.

J Cardiovasc Electrophysiol. 2010 Nov;21(11):1266-73. doi: 10.1111/j.1540-8167.2010.01803.x.


Repetitive endocardial focal discharges during ventricular fibrillation with prolonged global ischemia in isolated rabbit hearts.

Wu TJ, Lin SF, Hsieh YC, Chiu YT, Ting CT.

Circ J. 2009 Oct;73(10):1803-11. Epub 2009 Aug 4.


The importance of Purkinje activation in long duration ventricular fibrillation.

Huang J, Dosdall DJ, Cheng KA, Li L, Rogers JM, Ideker RE.

J Am Heart Assoc. 2014 Feb 28;3(1):e000495. doi: 10.1161/JAHA.113.000495.


Purkinje activation precedes myocardial activation following defibrillation after long-duration ventricular fibrillation.

Dosdall DJ, Osorio J, Robichaux RP, Huang J, Li L, Ideker RE.

Heart Rhythm. 2010 Mar;7(3):405-12. doi: 10.1016/j.hrthm.2009.11.025. Epub 2009 Dec 2.


Activation patterns of Purkinje fibers during long-duration ventricular fibrillation in an isolated canine heart model.

Tabereaux PB, Walcott GP, Rogers JM, Kim J, Dosdall DJ, Robertson PG, Killingsworth CR, Smith WM, Ideker RE.

Circulation. 2007 Sep 4;116(10):1113-9. Epub 2007 Aug 13.


The effect of chemical ablation of the endocardium on ventricular fibrillation threshold.

Damiano RJ Jr, Smith PK, Tripp HF Jr, Asano T, Small KW, Lowe JE, Ideker RE, Cox JL.

Circulation. 1986 Sep;74(3):645-52.


Long-duration ventricular fibrillation exhibits 2 distinct organized states.

Li L, Zheng X, Dosdall DJ, Huang J, Pogwizd SM, Ideker RE.

Circ Arrhythm Electrophysiol. 2013 Dec;6(6):1192-9. doi: 10.1161/CIRCEP.113.000459. Epub 2013 Nov 15.


Activation becomes highly organized during long-duration ventricular fibrillation in canine hearts.

Li L, Jin Q, Dosdall DJ, Huang J, Pogwizd SM, Ideker RE.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2046-53. doi: 10.1152/ajpheart.01196.2009. Epub 2010 Apr 9.


Complex structure of electrophysiological gradients emerging during long-duration ventricular fibrillation in the canine heart.

Venable PW, Taylor TG, Shibayama J, Warren M, Zaitsev AV.

Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1405-18. doi: 10.1152/ajpheart.00419.2010. Epub 2010 Aug 27.


The transmural activation sequence in porcine and canine left ventricle is markedly different during long-duration ventricular fibrillation.

Allison JS, Qin H, Dosdall DJ, Huang J, Newton JC, Allred JD, Smith WM, Ideker RE.

J Cardiovasc Electrophysiol. 2007 Dec;18(12):1306-12. Epub 2007 Oct 4.


Defibrillation threshold varies during different stages of ventricular fibrillation in canine hearts.

Jin Q, Zhou J, Zhang N, Lin C, Pang Y, Xin Y, Pan J, Gu G, Shen W, Wu L.

Heart Lung Circ. 2013 Feb;22(2):133-40. doi: 10.1016/j.hlc.2012.08.059. Epub 2012 Sep 27.


Transmural optical measurements of Vm dynamics during long-duration ventricular fibrillation in canine hearts.

Kong W, Ideker RE, Fast VG.

Heart Rhythm. 2009 Jun;6(6):796-802. doi: 10.1016/j.hrthm.2009.02.028. Epub 2009 Feb 24.


The effects of acute amiodarone on short- and long-duration ventricular defibrillation threshold in canines.

Wu L, Jin Q, Zhang N, Pang Y, Ren S, Zhou J, Lin C, Ling T, Gu G, Shen W, Huang J, Huang C.

J Cardiovasc Pharmacol. 2011 Oct;58(4):432-8. doi: 10.1097/FJC.0b013e318228a50c.


Effects of chemical subendocardial ablation on activation rate gradient during ventricular fibrillation.

Cha YM, Uchida T, Wolf PL, Peters BB, Fishbein MC, Karagueuzian HS, Chen PS.

Am J Physiol. 1995 Dec;269(6 Pt 2):H1998-2009.


Reentrant wave fronts in Wiggers' stage II ventricular fibrillation. Characteristics and mechanisms of termination and spontaneous regeneration.

Lee JJ, Kamjoo K, Hough D, Hwang C, Fan W, Fishbein MC, Bonometti C, Ikeda T, Karagueuzian HS, Chen PS.

Circ Res. 1996 Apr;78(4):660-75.


Pretreatment of BAPTA-AM suppresses the genesis of repetitive endocardial focal discharges and pacing-induced ventricular arrhythmia during global ischemia.

Wu TJ, Lin SF, Hsieh YC, Lin TC, Lin JC, Ting CT.

J Cardiovasc Electrophysiol. 2011 Oct;22(10):1154-62. doi: 10.1111/j.1540-8167.2011.02067.x. Epub 2011 Apr 13.

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