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Evaluation of the HC-04 cell line as an in vitro model for mechanistic assessment of changes in hepatic cytochrome P450 3A during adenovirus infection.

Wonganan P, Jonsson-Schmunk K, Callahan SM, Choi JH, Croyle MA.

Drug Metab Dispos. 2014 Jul;42(7):1191-201. doi: 10.1124/dmd.113.056663. Epub 2014 Apr 24.


Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells.

Thomas M, Bayha C, Vetter S, Hofmann U, Schwarz M, Zanger UM, Braeuning A.

Mol Pharmacol. 2015 Jun;87(6):1013-20. doi: 10.1124/mol.114.097402. Epub 2015 Mar 30.


The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model.

Bogacz A, Mrozikiewicz PM, Karasiewicz M, Bartkowiak-Wieczorek J, Majchrzycki M, Mikolajczak PL, Ozarowski M, Grzeskowiak E.

Biomed Res Int. 2014;2014:819093. doi: 10.1155/2014/819093. Epub 2014 Sep 11.


Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells.

Savary CC, Jossé R, Bruyère A, Guillet F, Robin MA, Guillouzo A.

Drug Metab Dispos. 2014 Aug;42(8):1235-40. doi: 10.1124/dmd.114.057786. Epub 2014 May 15.


Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.

Murayama N, van Beuningen R, Suemizu H, Guguen-Guillouzo C, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H.

Chem Res Toxicol. 2014 Feb 17;27(2):304-8. doi: 10.1021/tx4004374. Epub 2014 Feb 5.


Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.

Sueyoshi T, Li L, Wang H, Moore R, Kodavanti PR, Lehmler HJ, Negishi M, Birnbaum LS.

Toxicol Sci. 2014 Feb;137(2):292-302. doi: 10.1093/toxsci/kft243. Epub 2013 Nov 11.


The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism.

Roques BB, Leghait J, Lacroix MZ, Lasserre F, Pineau T, Viguié C, Martin PG.

Biochem Pharmacol. 2013 Oct 1;86(7):997-1039. doi: 10.1016/j.bcp.2013.08.012. Epub 2013 Aug 17.


Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors.

Paul KB, Thompson JT, Simmons SO, Vanden Heuvel JP, Crofton KM.

Toxicol In Vitro. 2013 Oct;27(7):2049-60. doi: 10.1016/j.tiv.2013.07.008. Epub 2013 Jul 27.


Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis.

Niu Y, Wu Z, Shen Q, Song J, Luo Q, You H, Shi G, Qin W.

Dig Liver Dis. 2013 Dec;45(12):1041-8. doi: 10.1016/j.dld.2013.06.004. Epub 2013 Jul 26.


Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.

Pimkaew P, Küblbeck J, Petsalo A, Jukka J, Suksamrarn A, Juvonen R, Auriola S, Piyachaturawat P, Honkakoski P.

Toxicol In Vitro. 2013 Sep;27(6):2005-12. doi: 10.1016/j.tiv.2013.07.004. Epub 2013 Jul 12.


Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.

Luckert C, Ehlers A, Buhrke T, Seidel A, Lampen A, Hessel S.

Toxicol Lett. 2013 Oct 24;222(2):180-8. doi: 10.1016/j.toxlet.2013.06.243. Epub 2013 Jul 8.


Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator.

Watanabe K, Sakurai K, Tsuchiya Y, Yamazoe Y, Yoshinari K.

Biochem Pharmacol. 2013 Aug 1;86(3):428-36. doi: 10.1016/j.bcp.2013.05.016. Epub 2013 May 31.


Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1.

Wang YM, Lin W, Chai SC, Wu J, Ong SS, Schuetz EG, Chen T.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):96-107. doi: 10.1016/j.taap.2013.05.014. Epub 2013 May 22.


Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia.

Niemira M, Dastych J, Mazerska Z.

Biochem Pharmacol. 2013 Jul 15;86(2):231-41. doi: 10.1016/j.bcp.2013.05.008. Epub 2013 May 18.


Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.

Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, Yoshinari K.

PLoS One. 2013 Apr 23;8(4):e61802. doi: 10.1371/journal.pone.0061802. Print 2013.


Coordinated roles of pregnane X receptor and constitutive androstane receptor in autoinduction of voriconazole metabolism in mice.

Ohbuchi M, Yoshinari K, Kaneko H, Matsumoto S, Inoue A, Kawamura A, Usui T, Yamazoe Y.

Antimicrob Agents Chemother. 2013 Mar;57(3):1332-8. doi: 10.1128/AAC.01900-12. Epub 2012 Dec 28.


Construction and characterization of peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1α over-expressing cell line derived from human hepatocyte carcinoma HepG2 cells).

Novotna A, Doricakova A, Pavek P, Dvorak Z.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Sep;157(3):214-21. doi: 10.5507/bp.2012.075. Epub 2012 Sep 5.


Establishment of a stable human cell line, HPL-A3, for use in reporter gene assays of cytochrome P450 3A inducers.

Sekimoto M, Sano S, Hosaka T, Nemoto K, Degawa M.

Biol Pharm Bull. 2012;35(5):677-85.

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