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Results: 1 to 20 of 130

1.

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation.

Yan M, Gingras MC, Dunlop EA, Nouët Y, Dupuy F, Jalali Z, Possik E, Coull BJ, Kharitidi D, Dydensborg AB, Faubert B, Kamps M, Sabourin S, Preston RS, Davies DM, Roughead T, Chotard L, van Steensel MA, Jones R, Tee AR, Pause A.

J Clin Invest. 2014 Jun 2;124(6):2640-50. doi: 10.1172/JCI71749. Epub 2014 Apr 24.

PMID:
24762438
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN.

Hasumi H, Baba M, Hasumi Y, Huang Y, Oh H, Hughes RM, Klein ME, Takikita S, Nagashima K, Schmidt LS, Linehan WM.

J Natl Cancer Inst. 2012 Nov 21;104(22):1750-64. doi: 10.1093/jnci/djs418. Epub 2012 Nov 12.

PMID:
23150719
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner.

Gharbi H, Fabretti F, Bharill P, Rinschen MM, Brinkkötter S, Frommolt P, Burst V, Schermer B, Benzing T, Müller RU.

Aging Cell. 2013 Aug;12(4):593-603. doi: 10.1111/acel.12081. Epub 2013 May 15.

PMID:
23566034
[PubMed - indexed for MEDLINE]
Free Article
4.

Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin.

Tee AR, Pause A.

Fam Cancer. 2013 Sep;12(3):367-72. doi: 10.1007/s10689-012-9576-9.

PMID:
23096221
[PubMed - indexed for MEDLINE]
5.

Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility.

Preston RS, Philp A, Claessens T, Gijezen L, Dydensborg AB, Dunlop EA, Harper KT, Brinkhuizen T, Menko FH, Davies DM, Land SC, Pause A, Baar K, van Steensel MA, Tee AR.

Oncogene. 2011 Mar 10;30(10):1159-73. doi: 10.1038/onc.2010.497. Epub 2010 Nov 8.

PMID:
21057536
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK.

Goncharova EA, Goncharov DA, James ML, Atochina-Vasserman EN, Stepanova V, Hong SB, Li H, Gonzales L, Baba M, Linehan WM, Gow AJ, Margulies S, Guttentag S, Schmidt LS, Krymskaya VP.

Cell Rep. 2014 Apr 24;7(2):412-23. doi: 10.1016/j.celrep.2014.03.025. Epub 2014 Apr 13.

PMID:
24726356
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Birt-Hogg-Dubé syndrome: from gene discovery to molecularly targeted therapies.

Schmidt LS.

Fam Cancer. 2013 Sep;12(3):357-64. doi: 10.1007/s10689-012-9574-y. Erratum in: Fam Cancer. 2013 Sep;12(3):365.

PMID:
23108783
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.

Baba M, Hong SB, Sharma N, Warren MB, Nickerson ML, Iwamatsu A, Esposito D, Gillette WK, Hopkins RF 3rd, Hartley JL, Furihata M, Oishi S, Zhen W, Burke TR Jr, Linehan WM, Schmidt LS, Zbar B.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15552-7. Epub 2006 Oct 6.

PMID:
17028174
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Folliculin regulates ampk-dependent autophagy and metabolic stress survival.

Possik E, Jalali Z, Nouët Y, Yan M, Gingras MC, Schmeisser K, Panaite L, Dupuy F, Kharitidi D, Chotard L, Jones RG, Hall DH, Pause A.

PLoS Genet. 2014 Apr 24;10(4):e1004273. doi: 10.1371/journal.pgen.1004273. eCollection 2014 Apr.

PMID:
24763318
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Birt-Hogg-Dube syndrome: clinicopathological features of the lung.

Furuya M, Nakatani Y.

J Clin Pathol. 2013 Mar;66(3):178-86. doi: 10.1136/jclinpath-2012-201200. Epub 2012 Dec 8. Review.

PMID:
23223565
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development.

Baba M, Keller JR, Sun HW, Resch W, Kuchen S, Suh HC, Hasumi H, Hasumi Y, Kieffer-Kwon KR, Gonzalez CG, Hughes RM, Klein ME, Oh HF, Bible P, Southon E, Tessarollo L, Schmidt LS, Linehan WM, Casellas R.

Blood. 2012 Aug 9;120(6):1254-61. doi: 10.1182/blood-2012-02-410407. Epub 2012 Jun 18.

PMID:
22709692
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The Birt-Hogg-Dubé tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis.

Gaur K, Li J, Wang D, Dutta P, Yan SJ, Tsurumi A, Land H, Wu G, Li WX.

Hum Mol Genet. 2013 Jan 15;22(2):284-99. doi: 10.1093/hmg/dds428. Epub 2012 Oct 16.

PMID:
23077212
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Birt-Hogg-Dube syndrome is a novel ciliopathy.

Luijten MN, Basten SG, Claessens T, Vernooij M, Scott CL, Janssen R, Easton JA, Kamps MA, Vreeburg M, Broers JL, van Geel M, Menko FH, Harbottle RP, Nookala RK, Tee AR, Land SC, Giles RH, Coull BJ, van Steensel MA.

Hum Mol Genet. 2013 Nov 1;22(21):4383-97. doi: 10.1093/hmg/ddt288. Epub 2013 Jun 19.

PMID:
23784378
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Unique mutation, accelerated mTOR signaling and angiogenesis in the pulmonary cysts of Birt-Hogg-Dubé syndrome.

Nishii T, Tanabe M, Tanaka R, Matsuzawa T, Okudela K, Nozawa A, Nakatani Y, Furuya M.

Pathol Int. 2013 Jan;63(1):45-55. doi: 10.1111/pin.12028. Epub 2013 Jan 18.

PMID:
23356225
[PubMed - indexed for MEDLINE]
15.

Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.

Medvetz DA, Khabibullin D, Hariharan V, Ongusaha PP, Goncharova EA, Schlechter T, Darling TN, Hofmann I, Krymskaya VP, Liao JK, Huang H, Henske EP.

PLoS One. 2012;7(11):e47842. doi: 10.1371/journal.pone.0047842. Epub 2012 Nov 6.

PMID:
23139756
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling.

Hong SB, Oh H, Valera VA, Stull J, Ngo DT, Baba M, Merino MJ, Linehan WM, Schmidt LS.

Mol Cancer. 2010 Jun 23;9:160. doi: 10.1186/1476-4598-9-160.

PMID:
20573232
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin.

Hudon V, Sabourin S, Dydensborg AB, Kottis V, Ghazi A, Paquet M, Crosby K, Pomerleau V, Uetani N, Pause A.

J Med Genet. 2010 Mar;47(3):182-9. doi: 10.1136/jmg.2009.072009. Epub 2009 Oct 19.

PMID:
19843504
[PubMed - indexed for MEDLINE]
18.

Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.

Lim TH, Fujikane R, Sano S, Sakagami R, Nakatsu Y, Tsuzuki T, Sekiguchi M, Hidaka M.

DNA Repair (Amst). 2012 Mar 1;11(3):259-66. doi: 10.1016/j.dnarep.2011.11.006. Epub 2011 Dec 29.

PMID:
22209521
[PubMed - indexed for MEDLINE]
19.

Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism.

Bardella C, Olivero M, Lorenzato A, Geuna M, Adam J, O'Flaherty L, Rustin P, Tomlinson I, Pollard PJ, Di Renzo MF.

Mol Cell Biol. 2012 Aug;32(15):3081-94. doi: 10.1128/MCB.06160-11. Epub 2012 May 29.

PMID:
22645311
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression.

Klomp JA, Petillo D, Niemi NM, Dykema KJ, Chen J, Yang XJ, Sääf A, Zickert P, Aly M, Bergerheim U, Nordenskjöld M, Gad S, Giraud S, Denoux Y, Yonneau L, Méjean A, Vasiliu V, Richard S, MacKeigan JP, Teh BT, Furge KA.

BMC Med Genomics. 2010 Dec 16;3:59. doi: 10.1186/1755-8794-3-59.

PMID:
21162720
[PubMed - indexed for MEDLINE]
Free PMC Article

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