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Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial.

Lohmander LS, Hellot S, Dreher D, Krantz EF, Kruger DS, Guermazi A, Eckstein F.

Arthritis Rheumatol. 2014 Jul;66(7):1820-31. doi: 10.1002/art.38614.


Brief report: intraarticular sprifermin not only increases cartilage thickness, but also reduces cartilage loss: location-independent post hoc analysis using magnetic resonance imaging.

Eckstein F, Wirth W, Guermazi A, Maschek S, Aydemir A.

Arthritis Rheumatol. 2015 Nov;67(11):2916-22. doi: 10.1002/art.39265.


A first-in-human, double-blind, randomised, placebo-controlled, dose ascending study of intra-articular rhFGF18 (sprifermin) in patients with advanced knee osteoarthritis.

Dahlberg LE, Aydemir A, Muurahainen N, G├╝hring H, Fredberg Edebo H, Krarup-Jensen N, Ladel CH, Jurvelin JS.

Clin Exp Rheumatol. 2016 May-Jun;34(3):445-50. Epub 2016 Mar 23.


Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study.

Pelletier JP, Raynauld JP, Berthiaume MJ, Abram F, Choquette D, Haraoui B, Beary JF, Cline GA, Meyer JM, Martel-Pelletier J.

Arthritis Res Ther. 2007;9(4):R74.


Brief Report: Cartilage Thickness Change as an Imaging Biomarker of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.

Eckstein F, Collins JE, Nevitt MC, Lynch JA, Kraus VB, Katz JN, Losina E, Wirth W, Guermazi A, Roemer FW, Hunter DJ; FNIH OA Biomarkers Consortium.

Arthritis Rheumatol. 2015 Dec;67(12):3184-9. doi: 10.1002/art.39324.


Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial.

McAlindon T, LaValley M, Schneider E, Nuite M, Lee JY, Price LL, Lo G, Dawson-Hughes B.

JAMA. 2013 Jan 9;309(2):155-62. doi: 10.1001/jama.2012.164487.


Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial.

Roemer FW, Aydemir A, Lohmander S, Crema MD, Marra MD, Muurahainen N, Felson DT, Eckstein F, Guermazi A.

BMC Musculoskelet Disord. 2016 Jul 9;17:267. doi: 10.1186/s12891-016-1128-2.


Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study.

Chevalier X, Goupille P, Beaulieu AD, Burch FX, Bensen WG, Conrozier T, Loeuille D, Kivitz AJ, Silver D, Appleton BE.

Arthritis Rheum. 2009 Mar 15;61(3):344-52. doi: 10.1002/art.24096.


Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial.

Raynauld JP, Buckland-Wright C, Ward R, Choquette D, Haraoui B, Martel-Pelletier J, Uthman I, Khy V, Tremblay JL, Bertrand C, Pelletier JP.

Arthritis Rheum. 2003 Feb;48(2):370-7. Erratum in: Arthritis Rheum. 2003 Nov;48(11):3300.


Correlation of WOMAC and KOOS scores to tibiofemoral cartilage loss on plain radiography and 3 Tesla MRI: data from the osteoarthritis initiative.

Illingworth KD, El Bitar Y, Siewert K, Scaife SL, El-Amin S, Saleh KJ.

Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1649-58. doi: 10.1007/s00167-013-2402-6. Epub 2013 Jan 23.


First-line analysis of the effects of treatment on progression of structural changes in knee osteoarthritis over 24 months: data from the osteoarthritis initiative progression cohort.

Martel-Pelletier J, Roubille C, Abram F, Hochberg MC, Dorais M, Delorme P, Raynauld JP, Pelletier JP.

Ann Rheum Dis. 2015 Mar;74(3):547-56. doi: 10.1136/annrheumdis-2013-203906. Epub 2013 Dec 13.


Increased cartilage volume after injection of hyaluronic acid in osteoarthritis knee patients who underwent high tibial osteotomy.

Chareancholvanich K, Pornrattanamaneewong C, Narkbunnam R.

Knee Surg Sports Traumatol Arthrosc. 2014 Jun;22(6):1415-23. doi: 10.1007/s00167-013-2735-1. Epub 2013 Oct 27.


A double blind, randomized, placebo controlled study to evaluate the efficacy of erythromycin in patients with knee effusion due to osteoarthritis.

Sadreddini S, Noshad H, Molaeefard M, Moloudi R, Ardalan MR, Ghojazadeh M.

Int J Rheum Dis. 2009 Apr;12(1):44-51. doi: 10.1111/j.1756-185X.2009.01379.x.


Lateral and medial joint space narrowing predict subsequent cartilage loss in the narrowed, but not in the non-narrowed femorotibial compartment--data from the Osteoarthritis Initiative.

Wirth W, Nevitt M, Hellio Le Graverand MP, Lynch J, Maschek S, Hudelmaier M, Eckstein F; OA Initiative Investigators Group.

Osteoarthritis Cartilage. 2014 Jan;22(1):63-70. doi: 10.1016/j.joca.2013.10.011. Epub 2013 Nov 1.


Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study.

Bingham CO 3rd, Buckland-Wright JC, Garnero P, Cohen SB, Dougados M, Adami S, Clauw DJ, Spector TD, Pelletier JP, Raynauld JP, Strand V, Simon LS, Meyer JM, Cline GA, Beary JF.

Arthritis Rheum. 2006 Nov;54(11):3494-507.


Effects of Hylan G-F 20 supplementation on cartilage preservation detected by magnetic resonance imaging in osteoarthritis of the knee: a two-year single-blind clinical trial.

Wang Y, Hall S, Hanna F, Wluka AE, Grant G, Marks P, Feletar M, Cicuttini FM.

BMC Musculoskelet Disord. 2011 Aug 24;12:195. doi: 10.1186/1471-2474-12-195.


Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173].

Spector TD, Conaghan PG, Buckland-Wright JC, Garnero P, Cline GA, Beary JF, Valent DJ, Meyer JM.

Arthritis Res Ther. 2005;7(3):R625-33. Epub 2005 Mar 24.


Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis.

Raynauld JP, Martel-Pelletier J, Abram F, Dorais M, Haraoui B, Choquette D, Bias P, Emmert KH, Laufer S, Pelletier JP.

Arthritis Res Ther. 2008;10(6):R129. doi: 10.1186/ar2543. Epub 2008 Nov 5.

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