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Derivative of bardoxolone methyl, dh404, in an inverse dose-dependent manner lessens diabetes-associated atherosclerosis and improves diabetic kidney disease.

Tan SM, Sharma A, Stefanovic N, Yuen DY, Karagiannis TC, Meyer C, Ward KW, Cooper ME, de Haan JB.

Diabetes. 2014 Sep;63(9):3091-103. doi: 10.2337/db13-1743. Epub 2014 Apr 16.


The Effect of Nrf2 Pathway Activation on Human Pancreatic Islet Cells.

Masuda Y, Vaziri ND, Li S, Le A, Hajighasemi-Ossareh M, Robles L, Foster CE, Stamos MJ, Al-Abodullah I, Ricordi C, Ichii H.

PLoS One. 2015 Jun 25;10(6):e0131012. doi: 10.1371/journal.pone.0131012. eCollection 2015.


Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease.

Vaziri ND, Liu S, Farzaneh SH, Nazertehrani S, Khazaeli M, Zhao YY.

Free Radic Biol Med. 2015 Apr 28. pii: S0891-5849(15)00185-9. doi: 10.1016/j.freeradbiomed.2015.04.022. [Epub ahead of print]


Pharmacological activation of Nrf2 pathway improves pancreatic islet isolation and transplantation.

Li S, Vaziri ND, Masuda Y, Hajighasemi-Ossareh M, Robles L, Le A, Vo K, Chan JY, Foster CE, Stamos MJ, Ichii H.

Cell Transplant. 2015 Jan 9. [Epub ahead of print]


Salutary effect of pre-treatment with an Nrf2 inducer on ischemia reperfusion injury in the rat liver.

Masuda Y, Vaziri ND, Takasu C, Li S, Robles L, Pham C, Le A, Vo K, Farzaneh SH, Stamos MJ, Ichii H.

Gastroenterol Hepatol (Que). 2014;1(1):1-7.


Is there a sweet spot for Nrf2 activation in the treatment of diabetic kidney disease?

Hall ET, Bhalla V.

Diabetes. 2014 Sep;63(9):2904-5. doi: 10.2337/db14-0829. No abstract available.


The paradox of bardoxolone methyl: a call for every witness on the stand?

Van Laecke S, Van Biesen W, Vanholder R.

Diabetes Obes Metab. 2015 Jan;17(1):9-14. doi: 10.1111/dom.12356. Epub 2014 Aug 4.


Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl.

Chin MP, Reisman SA, Bakris GL, O'Grady M, Linde PG, McCullough PA, Packham D, Vaziri ND, Ward KW, Warnock DG, Meyer CJ.

Am J Nephrol. 2014;39(6):499-508. doi: 10.1159/000362906. Epub 2014 Jun 3.


The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications.

Camer D, Yu Y, Szabo A, Huang XF.

Mol Nutr Food Res. 2014 Aug;58(8):1750-9. doi: 10.1002/mnfr.201300861. Epub 2014 Apr 17. Review.


Tracing the proteomic fingerprint of the diabetic aorta?

Suna G, Mayr M.

Circ Cardiovasc Genet. 2014 Apr;7(2):100-1. doi: 10.1161/CIRCGENETICS.114.000592. No abstract available.


Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function.

Wang Y, Zhang Z, Sun W, Tan Y, Liu Y, Zheng Y, Liu Q, Cai L, Sun J.

Oxid Med Cell Longev. 2014;2014:123963. doi: 10.1155/2014/123963. Epub 2014 Feb 23.


Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).

Impellizzeri D, Esposito E, Attley J, Cuzzocrea S.

Pharmacol Res. 2014 Mar;81:91-102. doi: 10.1016/j.phrs.2014.02.007. Epub 2014 Mar 3. Review.


Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease.

Husi H, Van Agtmael T, Mullen W, Bahlmann FH, Schanstra JP, Vlahou A, Delles C, Perco P, Mischak H.

Circ Cardiovasc Genet. 2014 Apr;7(2):161-70. doi: 10.1161/CIRCGENETICS.113.000196. Epub 2014 Feb 26.


Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling.

Hong YA, Lim JH, Kim MY, Kim EN, Koh ES, Shin SJ, Choi BS, Park CW, Chang YS, Chung S.

J Transl Med. 2014 Feb 21;12:50. doi: 10.1186/1479-5876-12-50.


Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much?

Tan SM, de Haan JB.

Redox Rep. 2014 May;19(3):107-17. doi: 10.1179/1351000214Y.0000000087. Epub 2014 Feb 21. Review.


Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway.

Wu J, Liu X, Fan J, Chen W, Wang J, Zeng Y, Feng X, Yu X, Yang X.

Toxicology. 2014 Apr 6;318:22-31. doi: 10.1016/j.tox.2014.01.008. Epub 2014 Feb 12.


Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2.

Li B, Abdalrahman A, Lai Y, Janicki JS, Ward KW, Meyer CJ, Wang XL, Tang D, Cui T.

Biochem Biophys Res Commun. 2014 Feb 21;444(4):555-61. doi: 10.1016/j.bbrc.2014.01.101. Epub 2014 Jan 29.


The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease.

Aminzadeh MA, Reisman SA, Vaziri ND, Shelkovnikov S, Farzaneh SH, Khazaeli M, Meyer CJ.

Redox Biol. 2013 Oct 31;1:527-31. doi: 10.1016/j.redox.2013.10.007. eCollection 2013.


Attenuation of diabetic nephropathy by Chaihuang-Yishen granule through anti-inflammatory mechanism in streptozotocin-induced rat model of diabetics.

Zhang H, Zhao T, Gong Y, Dong X, Zhang W, Sun S, Wang H, Gu Y, Lu X, Yan M, Li P.

J Ethnopharmacol. 2014;151(1):556-64. doi: 10.1016/j.jep.2013.11.020. Epub 2013 Nov 22.


The anti-inflammation effect of Moutan Cortex on advanced glycation end products-induced rat mesangial cells dysfunction and High-glucose-fat diet and streptozotocin-induced diabetic nephropathy rats.

Zhang MH, Feng L, Zhu MM, Gu JF, Jiang J, Cheng XD, Ding SM, Wu C, Jia XB.

J Ethnopharmacol. 2014;151(1):591-600. doi: 10.1016/j.jep.2013.11.015. Epub 2013 Nov 21.

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