Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 106

1.

Linked production of pyroglutamate-modified proteins via self-cleavage of fusion tags with TEV protease and autonomous N-terminal cyclization with glutaminyl cyclase in vivo.

Shih YP, Chou CC, Chen YL, Huang KF, Wang AH.

PLoS One. 2014 Apr 14;9(4):e94812. doi: 10.1371/journal.pone.0094812. eCollection 2014.

2.

Functional comparison of two human monocyte chemotactic protein-2 isoforms, role of the amino-terminal pyroglutamic acid and processing by CD26/dipeptidyl peptidase IV.

Van Coillie E, Proost P, Van Aelst I, Struyf S, Polfliet M, De Meester I, Harvey DJ, Van Damme J, Opdenakker G.

Biochemistry. 1998 Sep 8;37(36):12672-80.

PMID:
9730840
3.

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

Schilling S, Appl T, Hoffmann T, Cynis H, Schulz K, Jagla W, Friedrich D, Wermann M, Buchholz M, Heiser U, von Hörsten S, Demuth HU.

J Neurochem. 2008 Aug;106(3):1225-36. doi: 10.1111/j.1471-4159.2008.05471.x. Epub 2008 Jul 8.

4.

Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.

Cynis H, Scheel E, Saido TC, Schilling S, Demuth HU.

Biochemistry. 2008 Jul 15;47(28):7405-13. doi: 10.1021/bi800250p. Epub 2008 Jun 21.

PMID:
18570439
5.

Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers.

Seifert F, Demuth HU, Weichler T, Ludwig HH, Tittmann K, Schilling S.

Bioorg Chem. 2015 Jun;60:98-101. doi: 10.1016/j.bioorg.2015.04.005. Epub 2015 Apr 24.

PMID:
25981125
6.

Self-cleavage of fusion protein in vivo using TEV protease to yield native protein.

Shih YP, Wu HC, Hu SM, Wang TF, Wang AH.

Protein Sci. 2005 Apr;14(4):936-41. Epub 2005 Mar 1.

7.

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.

Cynis H, Schilling S, Bodnár M, Hoffmann T, Heiser U, Saido TC, Demuth HU.

Biochim Biophys Acta. 2006 Oct;1764(10):1618-25. Epub 2006 Aug 16.

PMID:
17005457
8.

Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation development.

Yu L, Vizel A, Huff MB, Young M, Remmele RL Jr, He B.

J Pharm Biomed Anal. 2006 Oct 11;42(4):455-63. Epub 2006 Jul 7.

PMID:
16828250
9.

Inhibition of glutaminyl cyclase attenuates cell migration modulated by monocyte chemoattractant proteins.

Chen YL, Huang KF, Kuo WC, Lo YC, Lee YM, Wang AH.

Biochem J. 2012 Mar 1;442(2):403-12. doi: 10.1042/BJ20110535.

PMID:
22060158
10.

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms.

Hartlage-Rübsamen M, Morawski M, Waniek A, Jäger C, Zeitschel U, Koch B, Cynis H, Schilling S, Schliebs R, Demuth HU, Rossner S.

Acta Neuropathol. 2011 Jun;121(6):705-19. doi: 10.1007/s00401-011-0806-2. Epub 2011 Feb 8.

11.

Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.

Schilling S, Lindner C, Koch B, Wermann M, Rahfeld JU, von Bohlen A, Rudolph T, Reuter G, Demuth HU.

Biochemistry. 2007 Sep 25;46(38):10921-30. Epub 2007 Aug 28.

PMID:
17722885
12.

Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease.

Morawski M, Schilling S, Kreuzberger M, Waniek A, Jäger C, Koch B, Cynis H, Kehlen A, Arendt T, Hartlage-Rübsamen M, Demuth HU, Roßner S.

J Alzheimers Dis. 2014;39(2):385-400. doi: 10.3233/JAD-131535.

PMID:
24164736
13.

Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.

Schilling S, Hoffmann T, Manhart S, Hoffmann M, Demuth HU.

FEBS Lett. 2004 Apr 9;563(1-3):191-6.

14.

Specific and efficient cleavage of fusion proteins by recombinant plum pox virus NIa protease.

Zheng N, Pérez Jde J, Zhang Z, Domínguez E, Garcia JA, Xie Q.

Protein Expr Purif. 2008 Feb;57(2):153-62. Epub 2007 Oct 22.

PMID:
18024078
15.

Improved solubility of TEV protease by directed evolution.

van den Berg S, Löfdahl PA, Härd T, Berglund H.

J Biotechnol. 2006 Feb 10;121(3):291-8. Epub 2005 Sep 15.

PMID:
16150509
16.

Controlled intracellular processing of fusion proteins by TEV protease.

Kapust RB, Waugh DS.

Protein Expr Purif. 2000 Jul;19(2):312-8.

PMID:
10873547
17.

A novel self-cleavage system for production of soluble recombinant protein in Escherichia coli.

Feng Y, Xu Q, Yang T, Sun E, Li J, Shi D, Wu D.

Protein Expr Purif. 2014 Jul;99:64-9. doi: 10.1016/j.pep.2014.04.001. Epub 2014 Apr 13.

PMID:
24727155
18.

Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates.

Seifert F, Schulz K, Koch B, Manhart S, Demuth HU, Schilling S.

Biochemistry. 2009 Dec 22;48(50):11831-3. doi: 10.1021/bi9018835.

PMID:
19921850
19.

Hyper-acidic protein fusion partners improve solubility and assist correct folding of recombinant proteins expressed in Escherichia coli.

Zou Z, Cao L, Zhou P, Su Y, Sun Y, Li W.

J Biotechnol. 2008 Jul 31;135(4):333-9. doi: 10.1016/j.jbiotec.2008.05.007. Epub 2008 May 27.

PMID:
18599143
20.

Method to convert N-terminal glutamine to pyroglutamate for characterization of recombinant monoclonal antibodies.

Xu W, Peng Y, Wang F, Paporello B, Richardson D, Liu H.

Anal Biochem. 2013 May 1;436(1):10-2. doi: 10.1016/j.ab.2013.01.017. Epub 2013 Jan 25.

PMID:
23357233
Items per page

Supplemental Content

Write to the Help Desk