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Results: 1 to 20 of 103

1.

Standing the test of time: targeting thymidylate biosynthesis in cancer therapy.

Wilson PM, Danenberg PV, Johnston PG, Lenz HJ, Ladner RD.

Nat Rev Clin Oncol. 2014 May;11(5):282-98. doi: 10.1038/nrclinonc.2014.51. Epub 2014 Apr 15.

PMID:
24732946
[PubMed - in process]
2.

Thymidylate synthase: a target for combination therapy and determinant of chemotherapeutic response in colorectal cancer.

Van Triest B, Peters GJ.

Oncology. 1999 Oct;57(3):179-94. Review.

PMID:
10545786
[PubMed - indexed for MEDLINE]
3.

The role of dUTPase and uracil-DNA repair in cancer chemotherapy.

Ladner RD.

Curr Protein Pept Sci. 2001 Dec;2(4):361-70. Review.

PMID:
12374095
[PubMed - indexed for MEDLINE]
4.

Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase.

Banerjee D, Mayer-Kuckuk P, Capiaux G, Budak-Alpdogan T, Gorlick R, Bertino JR.

Biochim Biophys Acta. 2002 Jul 18;1587(2-3):164-73. Review.

PMID:
12084458
[PubMed - indexed for MEDLINE]
Free Article
5.

Thymidylate synthase: a critical target in cancer therapy?

Rustum YM.

Front Biosci. 2004 Sep 1;9:2467-73. Review.

PMID:
15353299
[PubMed - indexed for MEDLINE]
6.

Future potential of thymidylate synthase inhibitors in cancer therapy.

Lehman NL.

Expert Opin Investig Drugs. 2002 Dec;11(12):1775-87. Review.

PMID:
12457437
[PubMed - indexed for MEDLINE]
7.

The means to an end of tumor cell resistance to chemotherapeutic drugs targeting thymidylate synthase: shoot the messenger.

Berg RW, Ferguso PJ, DeMoor JM, Vincen MD, Koropatnick J.

Curr Drug Targets. 2002 Aug;3(4):297-309. Review.

PMID:
12102601
[PubMed - indexed for MEDLINE]
8.

Thymidylate synthase inhibitors for non-small cell lung cancer.

Galvani E, Peters GJ, Giovannetti E.

Expert Opin Investig Drugs. 2011 Oct;20(10):1343-56. doi: 10.1517/13543784.2011.617742. Epub 2011 Sep 9. Review.

PMID:
21905922
[PubMed - indexed for MEDLINE]
9.
10.

Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors.

Rustum YM, Harstrick A, Cao S, Vanhoefer U, Yin MB, Wilke H, Seeber S.

J Clin Oncol. 1997 Jan;15(1):389-400. Review.

PMID:
8996166
[PubMed - indexed for MEDLINE]
11.

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.

Van Triest B, Pinedo HM, Giaccone G, Peters GJ.

Ann Oncol. 2000 Apr;11(4):385-91. Review.

PMID:
10847455
[PubMed - indexed for MEDLINE]
Free Article
12.

Novel opportunities for thymidylate metabolism as a therapeutic target.

Wilson PM, Fazzone W, LaBonte MJ, Deng J, Neamati N, Ladner RD.

Mol Cancer Ther. 2008 Sep;7(9):3029-37. doi: 10.1158/1535-7163.MCT-08-0280.

PMID:
18790783
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor.

Takezawa K, Okamoto I, Tanizaki J, Kuwata K, Yamaguchi H, Fukuoka M, Nishio K, Nakagawa K.

Mol Cancer Ther. 2010 Jun;9(6):1647-56. doi: 10.1158/1535-7163.MCT-09-1009. Epub 2010 Jun 8.

PMID:
20530710
[PubMed - indexed for MEDLINE]
Free Article
14.

Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer.

Wilson PM, LaBonte MJ, Lenz HJ, Mack PC, Ladner RD.

Mol Cancer Ther. 2012 Mar;11(3):616-28. doi: 10.1158/1535-7163.MCT-11-0781. Epub 2011 Dec 15.

PMID:
22172489
[PubMed - indexed for MEDLINE]
Free Article
15.

Thymidylate synthase: a critical target for cancer chemotherapy.

Rose MG, Farrell MP, Schmitz JC.

Clin Colorectal Cancer. 2002 Feb;1(4):220-9. Review.

PMID:
12450420
[PubMed - indexed for MEDLINE]
16.

[Recent advance in chemotherapy for advanced colorectal cancer].

Aiba K.

Gan To Kagaku Ryoho. 1996 Apr;23(5):535-48. Review. Japanese.

PMID:
8678510
[PubMed - indexed for MEDLINE]
17.

Thymidylate synthase inhibitors as anticancer agents: from bench to bedside.

Chu E, Callender MA, Farrell MP, Schmitz JC.

Cancer Chemother Pharmacol. 2003 Jul;52 Suppl 1:S80-9. Epub 2003 Jun 18. Review.

PMID:
12819937
[PubMed - indexed for MEDLINE]
18.

Combining small interfering RNAs targeting thymidylate synthase and thymidine kinase 1 or 2 sensitizes human tumor cells to 5-fluorodeoxyuridine and pemetrexed.

Di Cresce C, Figueredo R, Ferguson PJ, Vincent MD, Koropatnick J.

J Pharmacol Exp Ther. 2011 Sep;338(3):952-63. doi: 10.1124/jpet.111.183178. Epub 2011 Jun 14.

PMID:
21673071
[PubMed - indexed for MEDLINE]
Free Article
19.

5-fluorouracil: a pharmacological paradigm in the use of cytotoxics.

Thomas DM, Zalcberg JR.

Clin Exp Pharmacol Physiol. 1998 Nov;25(11):887-95. Review.

PMID:
9807659
[PubMed - indexed for MEDLINE]
20.

Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies.

Longley DB, Ferguson PR, Boyer J, Latif T, Lynch M, Maxwell P, Harkin DP, Johnston PG.

Clin Cancer Res. 2001 Nov;7(11):3533-9.

PMID:
11705873
[PubMed - indexed for MEDLINE]
Free Article

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