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Items: 1 to 20 of 152

1.

Synthesis and biological evaluation of novel 2-methoxypyridylamino-substituted riminophenazine derivatives as antituberculosis agents.

Zhang D, Liu Y, Zhang C, Zhang H, Wang B, Xu J, Fu L, Yin D, Cooper CB, Ma Z, Lu Y, Huang H.

Molecules. 2014 Apr 9;19(4):4380-94. doi: 10.3390/molecules19044380.

2.

Identification of less lipophilic riminophenazine derivatives for the treatment of drug-resistant tuberculosis.

Zhang D, Lu Y, Liu K, Liu B, Wang J, Zhang G, Zhang H, Liu Y, Wang B, Zheng M, Fu L, Hou Y, Gong N, Lv Y, Li C, Cooper CB, Upton AM, Yin D, Ma Z, Huang H.

J Med Chem. 2012 Oct 11;55(19):8409-17. doi: 10.1021/jm300828h. Epub 2012 Sep 20.

PMID:
22931472
3.

Clofazimine analogs with efficacy against experimental tuberculosis and reduced potential for accumulation.

Lu Y, Zheng M, Wang B, Fu L, Zhao W, Li P, Xu J, Zhu H, Jin H, Yin D, Huang H, Upton AM, Ma Z.

Antimicrob Agents Chemother. 2011 Nov;55(11):5185-93. doi: 10.1128/AAC.00699-11. Epub 2011 Aug 15.

4.

Systematic evaluation of structure-activity relationships of the riminophenazine class and discovery of a C2 pyridylamino series for the treatment of multidrug-resistant tuberculosis.

Liu B, Liu K, Lu Y, Zhang D, Yang T, Li X, Ma C, Zheng M, Wang B, Zhang G, Wang F, Ma Z, Li C, Huang H, Yin D.

Molecules. 2012 Apr 17;17(4):4545-59. doi: 10.3390/molecules17044545.

5.

Synthesis and anti-tubercular activity of novel alkyl substituted riminophenazine derivatives.

Li YL, Zhang CL, Zhang DF, Lu Y, Wang B, Zheng MQ, Li C, Yin DL, Huang HH.

Yao Xue Xue Bao. 2012 Jun;47(6):745-54.

PMID:
22919722
6.

In vitro investigation of the antimicrobial activities of novel tetramethylpiperidine-substituted phenazines against Mycobacterium tuberculosis.

van Rensburg CE, Jooné GK, Sirgel FA, Matlola NM, O'Sullivan JF.

Chemotherapy. 2000 Jan-Feb;46(1):43-8.

PMID:
10601797
7.

Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles.

Sasaki H, Haraguchi Y, Itotani M, Kuroda H, Hashizume H, Tomishige T, Kawasaki M, Matsumoto M, Komatsu M, Tsubouchi H.

J Med Chem. 2006 Dec 28;49(26):7854-60.

PMID:
17181168
8.

Antituberculosis activities of clofazimine and its new analogs B4154 and B4157.

Reddy VM, Nadadhur G, Daneluzzi D, O'Sullivan JF, Gangadharam PR.

Antimicrob Agents Chemother. 1996 Mar;40(3):633-36.

9.

Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis. In vitro, intracellular, and in vivo studies.

Jagannath C, Reddy MV, Kailasam S, O'Sullivan JF, Gangadharam PR.

Am J Respir Crit Care Med. 1995 Apr;151(4):1083-6.

PMID:
7697235
10.

Synthesis of novel [1,2]-diamines with antituberculosis activity.

Meng Q, Luo H, Chen Y, Wang T, Yao Q.

Bioorg Med Chem Lett. 2009 Sep 15;19(18):5372-5. doi: 10.1016/j.bmcl.2009.07.126. Epub 2009 Aug 6.

PMID:
19682895
12.

[A study on the activity of clofazimine with antituberculous drugs against Mycobacterium tuberculosis].

Lu Y, Wang B, Zhao WJ, Zheng MQ, Li P, Fu L, Liang BW.

Zhonghua Jie He He Hu Xi Za Zhi. 2010 Sep;33(9):675-8. Chinese.

PMID:
21092635
13.

Design, synthesis and antitubercular evaluation of novel series of N-[4-(piperazin-1-yl)phenyl]cinnamamide derivatives.

Patel KN, Telvekar VN.

Eur J Med Chem. 2014 Mar 21;75:43-56. doi: 10.1016/j.ejmech.2014.01.024. Epub 2014 Jan 25.

PMID:
24530490
14.

Synthesis and evaluation of novel monosubstituted sulfonylurea derivatives as antituberculosis agents.

Pan L, Jiang Y, Liu Z, Liu XH, Liu Z, Wang G, Li ZM, Wang D.

Eur J Med Chem. 2012 Apr;50:18-26. doi: 10.1016/j.ejmech.2012.01.011. Epub 2012 Jan 15.

PMID:
22326144
15.
16.

Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines.

Tonelli M, Novelli F, Tasso B, Sparatore A, Boido V, Sparatore F, Cannas S, Molicotti P, Zanetti S, Parapini S, Loddo R.

Bioorg Med Chem. 2014 Dec 15;22(24):6837-45. doi: 10.1016/j.bmc.2014.10.035. Epub 2014 Oct 31.

PMID:
25464882
17.

Synthesis of novel pleuromutilin derivatives. Part 1: preliminary studies of antituberculosis activity.

Dong YJ, Meng ZH, Mi YQ, Zhang C, Cui ZH, Wang P, Xu ZB.

Bioorg Med Chem Lett. 2015 Apr 15;25(8):1799-803. doi: 10.1016/j.bmcl.2015.02.023. Epub 2015 Feb 17.

PMID:
25736994
18.

In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.

Villar R, Vicente E, Solano B, Pérez-Silanes S, Aldana I, Maddry JA, Lenaerts AJ, Franzblau SG, Cho SH, Monge A, Goldman RC.

J Antimicrob Chemother. 2008 Sep;62(3):547-54. doi: 10.1093/jac/dkn214. Epub 2008 May 23.

19.

Synthesis and biological evaluation of trans 6-methoxy-1,1-dimethyl-2-phenyl-3-aryl-2,3-dihydro-1H-inden-4-yloxyalkylamine derivatives against drug susceptible, non-replicating M. tuberculosis H37Rv and clinical multidrug resistant strains.

Kumar S, Dwivedi AP, Kashyap VK, Saxena AK, Dwivedi AK, Srivastava R, Sahu DP.

Bioorg Med Chem Lett. 2013 Apr 15;23(8):2404-7. doi: 10.1016/j.bmcl.2013.02.030. Epub 2013 Feb 15.

PMID:
23474387
20.

Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents.

Pieroni M, Wan B, Cho S, Franzblau SG, Costantino G.

Eur J Med Chem. 2014 Jan 24;72:26-34. doi: 10.1016/j.ejmech.2013.11.007. Epub 2013 Nov 13.

PMID:
24333612
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