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Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice.

Duyvestyn JM, Taylor SJ, Dagger SA, Orandle M, Morse HC 3rd, Thien CB, Langdon WY.

PLoS One. 2014 Apr 9;9(4):e94717. doi: 10.1371/journal.pone.0094717. eCollection 2014.


CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.

Javadi M, Richmond TD, Huang K, Barber DL.

J Biol Chem. 2013 Jul 5;288(27):19459-70. doi: 10.1074/jbc.M113.475087. Epub 2013 May 21.


Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.

Rathinam C, Thien CB, Flavell RA, Langdon WY.

Cancer Cell. 2010 Oct 19;18(4):341-52. doi: 10.1016/j.ccr.2010.09.008.


Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy.

An W, Nadeau SA, Mohapatra BC, Feng D, Zutshi N, Storck MD, Arya P, Talmadge JE, Meza JL, Band V, Band H.

Oncotarget. 2015 Apr 30;6(12):10498-509.


Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells.

Konig H, Copland M, Chu S, Jove R, Holyoake TL, Bhatia R.

Cancer Res. 2008 Dec 1;68(23):9624-33. doi: 10.1158/0008-5472.CAN-08-1131.


The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells.

Oksvold MP, Dagger SA, Thien CB, Langdon WY.

Mol Immunol. 2008 Feb;45(4):925-36. Epub 2007 Sep 14.


The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase.

Ota S, Hazeki K, Rao N, Lupher ML Jr, Andoniou CE, Druker B, Band H.

J Biol Chem. 2000 Jan 7;275(1):414-22. Erratum in: J Biol Chem 2000 Feb 25;275(8):6046.


Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells.

Sattler M, Pride YB, Quinnan LR, Verma S, Malouf NA, Husson H, Salgia R, Lipkowitz S, Griffin JD.

Oncogene. 2002 Feb 21;21(9):1423-33.


Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins.

Nadeau S, An W, Palermo N, Feng D, Ahmad G, Dong L, Borgstahl GE, Natarajan A, Naramura M, Band V, Band H.

Biochem Anal Biochem. 2012 Jul 30;Suppl 6(1). pii: 7921.


As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia.

Mao JH, Sun XY, Liu JX, Zhang QY, Liu P, Huang QH, Li KK, Chen Q, Chen Z, Chen SJ.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21683-8. doi: 10.1073/pnas.1016311108. Epub 2010 Nov 30.


CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors.

Makishima H, Sugimoto Y, Szpurka H, Clemente MJ, Ng KP, Muramatsu H, O'Keefe C, Saunthararajah Y, Maciejewski JP.

Leukemia. 2012 Jul;26(7):1547-54. doi: 10.1038/leu.2012.7. Epub 2012 Jan 13.


Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5.

Ryan PE, Kales SC, Yadavalli R, Nau MM, Zhang H, Lipkowitz S.

PLoS One. 2012;7(11):e49428. doi: 10.1371/journal.pone.0049428. Epub 2012 Nov 7.


Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.

Gustin SE, Thien CB, Langdon WY.

J Immunol. 2006 Nov 1;177(9):5980-9.


CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes.

Reindl C, Quentmeier H, Petropoulos K, Greif PA, Benthaus T, Argiropoulos B, Mellert G, Vempati S, Duyster J, Buske C, Bohlander SK, Humphries KR, Hiddemann W, Spiekermann K.

Clin Cancer Res. 2009 Apr 1;15(7):2238-47. doi: 10.1158/1078-0432.CCR-08-1325. Epub 2009 Mar 10.


CBL mutations in myeloproliferative neoplasms are also found in the gene's proline-rich domain and in patients with the V617FJAK2.

Aranaz P, Hurtado C, Erquiaga I, Miguéliz I, Ormazábal C, Cristobal I, García-Delgado M, Novo FJ, Vizmanos JL.

Haematologica. 2012 Aug;97(8):1234-41. doi: 10.3324/haematol.2011.052605. Epub 2012 Feb 7.


c-kit ligand stimulates tyrosine phosphorylation of the c-Cbl protein in human hematopoietic cells.

Wisniewski D, Strife A, Clarkson B.

Leukemia. 1996 Sep;10(9):1436-42.

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