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Chronic leucine exposure results in reduced but reversible glucose-stimulated insulin secretion in INS-1 cells.

Zhang X, Han W, Jiang X, Li M, Gao L, Zhao JJ.

Mol Med Rep. 2014 Jun;9(6):2554-8. doi: 10.3892/mmr.2014.2122. Epub 2014 Apr 8.


AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells.

Zhang X, Sun N, Wang L, Guo H, Guan Q, Cui B, Tian L, Gao L, Zhao J.

J Cell Mol Med. 2009 Apr;13(4):758-70. doi: 10.1111/j.1582-4934.2009.00656.x.


Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate.

Sun Y, Zhang L, Gu HF, Han W, Ren M, Wang F, Gong B, Wang L, Guo H, Xin W, Zhao J, Gao L.

Endocrinology. 2008 Feb;149(2):662-71. Epub 2007 Nov 8.


Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.

Vetterli L, Brun T, Giovannoni L, Bosco D, Maechler P.

J Biol Chem. 2011 Feb 25;286(8):6049-60. doi: 10.1074/jbc.M110.176842. Epub 2010 Dec 16.


PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells.

Kim HS, Hwang YC, Koo SH, Park KS, Lee MS, Kim KW, Lee MK.

PLoS One. 2013;8(1):e50128. doi: 10.1371/journal.pone.0050128. Epub 2013 Jan 23.


Curcumin improves high glucose-induced INS-1 cell insulin resistance via activation of insulin signaling.

Song Z, Wang H, Zhu L, Han M, Gao Y, Du Y, Wen Y.

Food Funct. 2015 Feb;6(2):461-9. doi: 10.1039/c4fo00608a.


SREBP-1c, Pdx-1, and GLP-1R involved in palmitate-EPA regulated glucose-stimulated insulin secretion in INS-1 cells.

Shao S, Liu Z, Yang Y, Zhang M, Yu X.

J Cell Biochem. 2010 Oct 15;111(3):634-42. doi: 10.1002/jcb.22750.


Tumour necrosis factor-alpha-induced glucose-stimulated insulin secretion inhibition in INS-1 cells is ascribed to a reduction of the glucose-stimulated Ca2+ influx.

Kim HE, Choi SE, Lee SJ, Lee JH, Lee YJ, Kang SS, Chun J, Kang Y.

J Endocrinol. 2008 Sep;198(3):549-60. doi: 10.1677/JOE-08-0131. Epub 2008 Jul 1.


Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion.

Klett EL, Chen S, Edin ML, Li LO, Ilkayeva O, Zeldin DC, Newgard CB, Coleman RA.

J Biol Chem. 2013 Jul 26;288(30):21618-29. doi: 10.1074/jbc.M113.481077. Epub 2013 Jun 13.


Chronic palmitate exposure inhibits AMPKalpha and decreases glucose-stimulated insulin secretion from beta-cells: modulation by fenofibrate.

Sun Y, Ren M, Gao GQ, Gong B, Xin W, Guo H, Zhang XJ, Gao L, Zhao JJ.

Acta Pharmacol Sin. 2008 Apr;29(4):443-50. doi: 10.1111/j.1745-7254.2008.00717.x.


PRMT1 promotes glucose toxicity-induced β cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells.

Lv L, Chen H, Sun J, Lu D, Chen C, Liu D.

Endocrine. 2015 Aug;49(3):669-82. doi: 10.1007/s12020-015-0543-8. Epub 2015 Feb 10.


Caffeic acid, naringenin and quercetin enhance glucose-stimulated insulin secretion and glucose sensitivity in INS-1E cells.

Bhattacharya S, Oksbjerg N, Young JF, Jeppesen PB.

Diabetes Obes Metab. 2014 Jul;16(7):602-12. doi: 10.1111/dom.12236. Epub 2013 Dec 2.


Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells.

Matsunaga T, Li S, Adachi T, Joo E, Gu N, Yamazaki H, Yasuda K, Kondoh T, Tsuda K.

Biosci Biotechnol Biochem. 2014;78(5):843-50. doi: 10.1080/09168451.2014.905175. Epub 2014 May 28.


2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone protects the impaired insulin secretion induced by glucotoxicity in pancreatic β-cells.

Hu YC, Hao DM, Zhou LX, Zhang Z, Huang N, Hoptroff M, Lu YH.

J Agric Food Chem. 2014 Feb 19;62(7):1602-8. doi: 10.1021/jf405365d. Epub 2014 Feb 5.


Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner.

Park KG, Lee KM, Seo HY, Suh JH, Kim HS, Wang L, Won KC, Lee HW, Park JY, Lee KU, Kim JG, Kim BW, Choi HS, Lee IK.

Diabetes. 2007 Feb;56(2):431-7.


C-Abl inhibitor imatinib enhances insulin production by β cells: c-Abl negatively regulates insulin production via interfering with the expression of NKx2.2 and GLUT-2.

Xia CQ, Zhang P, Li S, Yuan L, Xia T, Xie C, Clare-Salzler MJ.

PLoS One. 2014 May 16;9(5):e97694. doi: 10.1371/journal.pone.0097694. eCollection 2014.


TCF2 attenuates FFA-induced damage in islet β-cells by regulating production of insulin and ROS.

Quan X, Zhang L, Li Y, Liang C.

Int J Mol Sci. 2014 Jul 30;15(8):13317-32. doi: 10.3390/ijms150813317.


The activation of the rat insulin gene II by BETA2 and PDX-1 in rat insulinoma cells is repressed by Pax6.

Wolf G, Hessabi B, Karkour A, Henrion U, Dahlhaus M, Ostmann A, Giese B, Fraunholz M, Grabarczyk P, Jack R, Walther R.

Mol Endocrinol. 2010 Dec;24(12):2331-42. doi: 10.1210/me.2009-0220. Epub 2010 Oct 13.


Palmitic acid increase levels of pancreatic duodenal homeobox-1 and p38/stress-activated protein kinase in islets from rats maintained on a low protein diet.

Arantes VC, Reis MA, Latorraca MQ, Ferreira F, Stoppiglia LF, Carneiro EM, Boschero AC.

Br J Nutr. 2006 Dec;96(6):1006-12.


B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic β-cells.

Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD.

Exp Mol Med. 2013 May 24;45:e25. doi: 10.1038/emm.2013.47.

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