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24714080,24566141,17684158,16199861,20451517,18164688,19956887,20595005,17693058,22842544,26992204,17393432,18980244,25619640,22911475,16951203,21170508,16820965,17510429,19345731,20360945,20403343,27927016,16983347,20127709,21317202,22895655,17804742,22266862,24946096,26261530,20099277,17982483,19409438,19250737,19426671,17638906,20071162,15897917,18056199,23007278,17308080,19942932,23615398,28270653,22174792,26415225,26448608,17145853,20113484,23247197,23319802,25675293,17332355,26142735,24556678,22008998,17172826,25824746,30463333,25684663,28350076,29434187,18838202,21150246,22072062,18645030,25539708,19896469,20886583,20706274,25522273,22345097,29444104,23371323,30004456,25535898,18391984,26344902,18314627,30409427,26499766,30817944,21914854,33050112,29305260,18790747,19001438,32568826,23470529,26122536,21835222,25017974,25593641,29045468,20300110,27477310,27528031,31817770,21513580,31269715,17136319,25577511,19808964,26725939,31443721,24462458,20430723,29374180,22932446,17604333,18483303,21435442,26669511,19282655,29044596,29186071,17187253,27517746,19385057,25955843,19470406,21465524,20515944,28158902,23674352,16373712,25333816,24603337,21483669,30189637,27210546,23634944,29048631,18209050,32958259,22722337,21914219,23519470,20442774,24662747,19966861,28035061,31810928,17545621,20227749,28669929,24362439,25483927,30138966,20951169,24352466,27418138,21877938,29363524,24438025,25456211,27620505,23070002,30864709,26305116,21107885,25524636,19734124,25030086,21525012,24351837,22551975,21252908,24009772,25790448,29615720,22105511,29137114,25477070,26198640,24118446,20508645,26648023,25997253,19155307,30745824,19625063,27406983,29445085,27321185,18726983,32319535,19106626,20237495,29792947,21427355,20570920,22190004,19158480,31173255,24535016,26733332,22389381,35341775,26552967,25940306,27582546,25903858,26972480,20559023,30146703,25564356,29847773,17237443,36302756,28282786,21725207,26997114,26837170,19538462,27569287,28319830,25738497,25892866,30360403,23951244,26114294,30594131,32589349,30745855,23944369,35247069,26319555,24530290,18590703,26397365,21486277,29859833,26291325,31810927,27433879,19564891,16373718,29423112,18988868,17893044,23051914,34820749,26802022,28230853,26760500,25791481,30223924,18339897,28771824,31284427,20446019,21480219,30111296,25661368,17909052,31387554,30445633,29094287,26245871,27856330,24335168,30504817,25926238,22673193,33416145,24488010,18256533,24299309,20224598,16894031,33731677,33050333,28147330,28249155,18288942,32951587,21855847,24462945,25843797,28153010,31621074,23525940,23371318,25818187,25719250,34004440,24253938,25257790,30905926,27136013,24810045,28806703,24589226,21403465,22735790,27541445,25981932,30626087,32075108,28242651,22370480,27565731,25254953,19197243,25043857,35985770,26172298,25953765,28693242,28964970,22189713,29285650,28339020,30172026,28302032,31959913,34062070,32099330,34282169,22207109,26692480,18815214,33543290,19419383,27262901,17339495,16537561,30053908,27371846,25997252,30158588,23559011,21307400,31178149,26921394,32135301,25402373,25230899,24355299,22884570,25412619,17617740,33929389,22252099,30666163,27814614,23682785,19906927,26725558,29684585,30954547,27654259,28427860,33714781,31367187,28393693,25379355,23625539,28182008,25464817,25391818,30857853,31780804,27602497,32155622,32701561,18306465,29807029,34481229,25682199,22955948,32994182,29796174,29897998,33350292,24859412,19664596,36644866,31789387,30862047,29296202,34973957,25076330,22500211,22348197,24901052,34545139,27600753,28276898,25988874,31959810,33946426,18239193,28776332,34238932,25551360,29705631,34141868,19437488,31032087,29167573,26467463,30008897,34716292,25196138,19519499,29212182,27634387,24644425,26622608,22467081,30729133,31633707,35780231,24943970,21757621,28122334,26372952,26242912,23926673,30259865,30132243,31262890,21324892,20398632,29245957,28423712,30849634,29512924,34234193,27748082,27082123,22659796,24520038,30569144,19372741,30173657,24505341,12189147,36322951,21924289,24901053,25471732,35783012,32504778,31205529,25959860,23256568,28193839,34628168,21307398,24578888,30860580,21483040,31817696,34271418,26276089,33198065,26277279,25107315,36746021,30730779,29434473,32352084,28900501,34363385,27775072,25785838,18474261,33895929,21516824,18793616,30200299,25013758,33375360,30705751,21153369,22467079,26126434,34607979,35771397,27219055,36356901,30290005,23159623,25734181,25996744,31261735,21116131,36400248,36938467,28028542,18719390,25642303,26885449,25073380,35754740,29069736,28157435,29922884,32781368,29318799,26177636,31955911,28373897,34760712,35597193,30061958[uid]

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510 results

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Metformin sensitizes human bladder cancer cells to TRAIL-induced apoptosis through mTOR/S6K1-mediated downregulation of c-FLIP.

Zhang T, Wang X, He D, Jin X, Guo P. Zhang T, et al. Anticancer Drugs. 2014 Sep;25(8):887-97. doi: 10.1097/CAD.0000000000000116. Anticancer Drugs. 2014. PMID: 24714080

Evodiamine induces apoptosis and enhances TRAIL-induced apoptosis in human bladder cancer cells through mTOR/S6K1-mediated downregulation of Mcl-1.

Zhang T, Qu S, Shi Q, He D, Jin X. Zhang T, et al. Int J Mol Sci. 2014 Feb 21;15(2):3154-71. doi: 10.3390/ijms15023154. Int J Mol Sci. 2014. PMID: 24566141 Free PMC article.

CCAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction and ubiquitin/proteasome-mediated cellular FLICE-inhibitory protein down-regulation contribute to enhancement of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by dimethyl-celecoxib in human non small-cell lung cancer cells.

Chen S, Liu X, Yue P, Schönthal AH, Khuri FR, Sun SY. Chen S, et al. Mol Pharmacol. 2007 Nov;72(5):1269-79. doi: 10.1124/mol.107.037465. Epub 2007 Aug 7. Mol Pharmacol. 2007. PMID: 17684158

mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells.

Panner A, James CD, Berger MS, Pieper RO. Panner A, et al. Mol Cell Biol. 2005 Oct;25(20):8809-23. doi: 10.1128/MCB.25.20.8809-8823.2005. Mol Cell Biol. 2005. PMID: 16199861 Free PMC article.

Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1.

Jang JH, Lee TJ, Yang ES, Min do S, Kim YH, Kim SH, Choi YH, Park JW, Choi KS, Kwon TK. Jang JH, et al. Exp Cell Res. 2010 Aug 1;316(13):2194-203. doi: 10.1016/j.yexcr.2010.04.028. Epub 2010 May 6. Exp Cell Res. 2010. PMID: 20451517

Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP.

Kim YH, Jung EM, Lee TJ, Kim SH, Choi YH, Park JW, Park JW, Choi KS, Kwon TK. Kim YH, et al. Free Radic Biol Med. 2008 Mar 15;44(6):1055-68. doi: 10.1016/j.freeradbiomed.2007.12.001. Epub 2007 Dec 8. Free Radic Biol Med. 2008. PMID: 18164688

The sesquiterpene lactone eupatolide sensitizes breast cancer cells to TRAIL through down-regulation of c-FLIP expression.

Lee J, Hwangbo C, Lee JJ, Seo J, Lee JH. Lee J, et al. Oncol Rep. 2010 Jan;23(1):229-37. Oncol Rep. 2010. PMID: 19956887

Programmed cell death 4 (PDCD4) mediates the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by down-regulation of FLIP expression.

Wang W, Zhao J, Wang H, Sun Y, Peng Z, Zhou G, Fan L, Wang X, Yang S, Wang R, Fang D. Wang W, et al. Exp Cell Res. 2010 Sep 10;316(15):2456-64. doi: 10.1016/j.yexcr.2010.05.027. Epub 2010 Jun 2. Exp Cell Res. 2010. PMID: 20595005

Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells.

Wang P, Zhang J, Bellail A, Jiang W, Hugh J, Kneteman NM, Hao C. Wang P, et al. Cell Signal. 2007 Nov;19(11):2237-46. doi: 10.1016/j.cellsig.2007.06.001. Epub 2007 Jun 21. Cell Signal. 2007. PMID: 17693058

Antimycin A sensitizes cells to TRAIL-induced apoptosis through upregulation of DR5 and downregulation of c-FLIP and Bcl-2.

Lee SJ, Kim EA, Song KS, Kim MJ, Lee DH, Kwon TK, Lee TJ. Lee SJ, et al. Int J Oncol. 2012 Oct;41(4):1425-30. doi: 10.3892/ijo.2012.1575. Epub 2012 Jul 27. Int J Oncol. 2012. PMID: 22842544

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